Opportunity Information: Apply for RFA HL 10 008
Apply for RFA HL 10 008
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Centers for Cardiovascular Outcomes Research (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Oct 19, 2009 and posted on Oct 19, 2009.
- Applicants must submit their applications by Jan 21, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,100,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $920,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NHLBI Centers for Cardiovascular Outcomes Research (CCOR) opportunity (Funding Opportunity Number RFA HL 10 008) is a four year NIH cooperative agreement (U01) designed to create a small network of specialized research centers focused on real world cardiovascular outcomes and comparative effectiveness research. NHLBI planned to fund three CCORs that would both complement and actively collaborate with other existing cardiovascular outcomes research efforts. A key feature is that this FOA is paired with a separate, parallel solicitation for a Research Coordinating Unit (RFA HL 10 018), meaning the centers funded under this announcement were expected to work in a coordinated structure rather than operate as fully independent projects.
The scientific focus is on generating evidence that matters directly to patients, clinicians, health systems, and policy makers. Rather than emphasizing traditional tightly controlled efficacy trials, the CCOR program targets research approaches suited to everyday healthcare settings, including natural experiments, quasi experimental designs, and practice based trials. The intent is to understand what works in routine care, for whom it works, under what conditions, and at what cost, with the explicit goal of producing findings that can inform public policy decisions and or change clinical practice. In other words, this program is aimed at actionable evidence about cardiovascular care delivery across the full continuum of care, from prevention and diagnosis to treatment, follow up, and long term management.
Each funded center was expected to run one to two major research projects and to do so through multidisciplinary teams. The FOA highlights the need to combine clinical expertise with methods and perspectives from health services research, biostatistics, and health economics, reflecting the complexity of outcomes research in real healthcare systems. The outcomes of interest are patient and clinician relevant and include endpoints such as cardiovascular mortality and other clinical events, as well as economic and patient centered measures like cost effectiveness and quality of life. The program also supports both applied work (for example, evaluating a care delivery change in a health system) and methodological innovation (for example, improving outcomes measurement or designing stronger quasi experimental approaches).
The kinds of aims the FOA encourages include measuring and improving quality of cardiovascular care at multiple levels, such as patient level factors, clinician decision making, and system level structures and incentives. It also emphasizes translating research results into practical strategies that clinicians, administrators, and decision makers can implement, as well as improving the effectiveness and efficiency of delivering evidence based cardiovascular care. Another major emphasis is advancing the methods used in outcomes research, including better measurement science and new study designs and statistical techniques suited to quasi experimental cardiovascular research, where randomization may not be feasible but rigorous causal inference is still needed.
Administratively, this is a discretionary funding opportunity in the health activity category under CFDA 93.837 (Cardiovascular Diseases Research). NHLBI anticipated three awards, with an estimated total program funding of about $4.1 million and an award ceiling listed as $920,000. There was no cost sharing or matching requirement. The FOA was posted October 19, 2009, with an original and current closing date of January 21, 2010, and it was archived February 21, 2010.
Eligibility was broad and included public and private institutions of higher education, nonprofits (including 501(c)(3) and non 501(c)(3) organizations), for profit organizations (including small businesses), state governments, federally recognized tribal governments, and a range of other eligible entities noted in the announcement. These additional eligible applicants included federally eligible agencies, faith based and community based organizations, HBCUs, Hispanic serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, regional organizations, and U.S. territories or possessions. Overall, the program was structured to bring together diverse institutions capable of conducting rigorous, policy relevant cardiovascular outcomes research in real world settings, while coordinating efforts across a small set of centers to maximize impact and consistency.
Frequently Asked Questions (FAQs): NHLBI Centers for Cardiovascular Outcomes Research (CCOR) - RFA HL 10 008
What is the NHLBI Centers for Cardiovascular Outcomes Research (CCOR) funding opportunity?
The CCOR opportunity (Funding Opportunity Number RFA HL 10 008) is a four-year NIH cooperative agreement (U01) intended to build a small network of specialized research centers focused on real-world cardiovascular outcomes research and comparative effectiveness research.
What type of award mechanism is used?
This opportunity uses an NIH cooperative agreement mechanism (U01), meaning the program is structured for coordinated work across a set of funded centers rather than fully independent projects.
How long is the project period?
The project period is four years.
How many awards did NHLBI plan to make?
NHLBI anticipated making three CCOR awards under this announcement.
What is the expected total funding for the program?
The estimated total program funding described for this FOA is about $4.1 million.
What is the award ceiling listed in the opportunity?
The award ceiling listed in the FOA is $920,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the main scientific purpose of the CCOR program?
The program is designed to generate evidence that directly matters to patients, clinicians, health systems, and policy makers. The emphasis is on actionable findings that can inform public policy decisions and/or change clinical practice in cardiovascular care.
How is the CCOR scientific focus different from traditional efficacy trials?
Rather than emphasizing tightly controlled efficacy trials, CCOR targets approaches suited to everyday healthcare settings. Examples mentioned include natural experiments, quasi-experimental designs, and practice-based trials intended to understand what works in routine care, for whom, under what conditions, and at what cost.
What parts of cardiovascular care does the FOA cover?
The FOA emphasizes cardiovascular care delivery across the full continuum of care, including prevention, diagnosis, treatment, follow-up, and long-term management.
What kinds of research approaches does the FOA encourage?
Approaches highlighted include natural experiments, quasi-experimental designs, and practice-based trials, along with other methods appropriate for real-world healthcare systems where randomization may not be feasible but rigorous causal inference is still needed.
What does "comparative effectiveness research" mean in the context of this opportunity?
Based on the FOA description, the comparative effectiveness emphasis is on determining what works in routine cardiovascular care settings and comparing strategies or delivery approaches in ways that produce practical, decision-relevant evidence for patients, clinicians, health systems, and policy makers.
What outcomes are of interest under this FOA?
The FOA emphasizes patient- and clinician-relevant outcomes, including cardiovascular mortality and other clinical events. It also includes economic and patient-centered measures such as cost effectiveness and quality of life.
Are both applied and methods-focused projects allowed?
Yes. The FOA supports applied work (for example, evaluating a care delivery change within a health system) and methodological innovation (for example, improving outcomes measurement or designing stronger quasi-experimental approaches).
How many major research projects should each funded center run?
Each funded center was expected to run one to two major research projects.
What kind of team structure is expected for a CCOR center?
The FOA expects multidisciplinary teams, specifically highlighting the need to combine clinical expertise with methods and perspectives from health services research, biostatistics, and health economics.
What kinds of aims does the FOA encourage related to quality of care?
The FOA encourages measuring and improving the quality of cardiovascular care at multiple levels, including patient-level factors, clinician decision making, and system-level structures and incentives.
Does the program emphasize translation of findings into practice?
Yes. A stated emphasis is translating research results into practical strategies that clinicians, administrators, and decision makers can implement.
What does the FOA say about improving cardiovascular care delivery?
The FOA emphasizes improving the effectiveness and efficiency of delivering evidence-based cardiovascular care in real-world settings.
What is the FOA emphasis on methods development?
A major emphasis is advancing outcomes research methods, including better measurement science and new study designs and statistical techniques suited to quasi-experimental cardiovascular research.
Why does the FOA mention quasi-experimental research specifically?
The FOA notes that in many real-world cardiovascular care settings randomization may not be feasible, so rigorous quasi-experimental approaches and causal inference methods are needed to produce strong evidence.
How is this CCOR FOA connected to the Research Coordinating Unit solicitation?
This FOA (RFA HL 10 008) is paired with a separate, parallel solicitation for a Research Coordinating Unit (RFA HL 10 018). The centers funded under this announcement were expected to work within a coordinated structure supported by that parallel solicitation, rather than operating as fully independent projects.
What is the NIH institute associated with this program?
The program is associated with NHLBI (the National Heart, Lung, and Blood Institute).
What is the CFDA number and program category?
The FOA is listed under CFDA 93.837 (Cardiovascular Diseases Research) and is described as a discretionary funding opportunity in the health activity category.
When was the FOA posted and when did it close?
The FOA was posted on October 19, 2009. The original and current closing date listed is January 21, 2010.
Is the funding opportunity still active?
No. The FOA was archived on February 21, 2010.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), state governments, federally recognized tribal governments, and other eligible entities noted in the announcement.
Do faith-based and community-based organizations appear to be eligible?
Yes. The eligibility list includes faith-based and community-based organizations.
Are minority-serving institutions included in the eligibility list?
Yes. The FOA notes eligibility for HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and other listed categories.
Are U.S. territories or possessions included as eligible entities?
Yes. The eligibility list includes U.S. territories or possessions.
What is the overall program structure and why is it designed that way?
The program is structured as a small network of centers intended to complement and actively collaborate with existing cardiovascular outcomes research efforts. The paired coordinating-unit solicitation underscores the expectation of coordinated operations to maximize impact and consistency across centers.
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Previous opportunity: NHLBI Cardiovascular Outcomes Research Coordinating Unit (U01)
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