Opportunity Information: Apply for RFA HL 17 011
Apply for RFA HL 17 011
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "NHLBI TOPMed Program: Integrative Omics Approaches for Analysis of TOPMed Data (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840,.
- This funding opportunity was created on Apr 18, 2016 and posted on Apr 18, 2016.
- Applicants must submit their applications by Jul 06, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity "NHLBI TOPMed Program: Integrative Omics Approaches for Analysis of TOPMed Data (U01)" (RFA HL 17 011) is a National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement designed to bring additional research teams into the Trans-Omics for Precision Medicine (TOPMed) program. TOPMed is a large-scale precision medicine effort that generates and organizes high-throughput "omics" datasets with the goal of identifying molecular patterns, abnormalities, and biological signatures linked to heart, lung, blood, and sleep disorders. The core idea behind this FOA is to support investigators who can analyze TOPMed-generated data at scale, integrate multiple types of omics information, and create methods and tools that make these complex datasets more useful to the broader scientific community.
A major emphasis of the FOA is integrative omics analysis. Rather than focusing on a single data layer (for example, genetics alone), TOPMed is positioned around combining multiple high-dimensional molecular measurements to better understand disease mechanisms and variation across individuals and populations. Projects supported under this announcement are expected to carry out advanced analyses on data produced by TOPMed, extracting insights that could clarify biological pathways, improve risk prediction, refine disease subtypes, or reveal targets relevant to prevention and treatment. The announcement also highlights the expectation that awardees will help expand the "TOPMed information commons," meaning not only producing findings, but also contributing analytic approaches, software, pipelines, and other resources that enable advanced genomic and multi-omics research using TOPMed datasets.
Because this is a U01 cooperative agreement, the work is meant to be collaborative and closely coordinated with NHLBI and the larger TOPMed consortium rather than operating as a fully independent investigator-initiated grant. In practice, that typically implies active engagement with program leadership and other TOPMed-funded groups, alignment with consortium standards for data use and sharing, and participation in joint planning or working groups so that outputs (analyses, tools, and derived resources) fit into a shared ecosystem. The program structure is geared toward producing consortium-wide value: rigorous, reusable analytic methods; scalable strategies for working with large genomic datasets; and deliverables that can be shared and adopted by other researchers working in TOPMed and related efforts.
The FOA was posted and created on April 18, 2016, with an original and current closing date of July 6, 2016. The agency is HHS-NIH, specifically NHLBI. The opportunity is categorized as discretionary funding and uses the cooperative agreement funding instrument. It falls under the health funding activity category and references CFDA numbers 93.233, 93.837, 93.838, 93.839, and 93.840, reflecting the NHLBI and related NIH program areas supporting this initiative.
In terms of funding scale, the listed award ceiling is $400,000, and the announcement anticipated making about 5 awards. Eligibility is broad and spans many organization types, including state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed by the FOA's additional eligibility language.
Overall, the opportunity is best understood as a call for teams with strong capabilities in statistical genetics, computational biology, bioinformatics, multi-omics integration, and tool building, with a clear expectation of producing shareable outputs that strengthen TOPMed as a community resource. The central deliverables are not just publications, but also analyses and reusable tools that improve how researchers can interrogate TOPMed data to accelerate discovery in heart, lung, blood, and sleep-related disease research.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "NHLBI TOPMed Program: Integrative Omics Approaches for Analysis of TOPMed Data (U01)" and is associated with RFA HL 17 011.
Which agency is offering this grant?
The sponsoring agency is HHS-NIH, specifically the National Heart, Lung, and Blood Institute (NHLBI).
What type of funding mechanism is used?
This opportunity uses a U01 cooperative agreement funding instrument, which is designed for projects that are expected to be collaborative and closely coordinated with NHLBI and the broader TOPMed consortium.
What is the overall purpose of this FOA?
The FOA is meant to bring additional research teams into the Trans-Omics for Precision Medicine (TOPMed) program to analyze TOPMed-generated data at scale, integrate multiple omics data types, and produce methods and tools that make TOPMed datasets more useful to the wider research community.
What is TOPMed?
TOPMed (Trans-Omics for Precision Medicine) is a large-scale precision medicine effort that generates and organizes high-throughput "omics" datasets to identify molecular patterns, abnormalities, and biological signatures associated with heart, lung, blood, and sleep disorders.
What does "integrative omics" mean in the context of this FOA?
Integrative omics refers to combining multiple high-dimensional molecular measurement types rather than focusing on a single data layer (such as genetics alone). The goal is to better understand disease mechanisms and differences across individuals and populations using multiple omics signals together.
What kinds of projects are expected to be competitive?
Based on the description, competitive projects are expected to perform advanced analyses of TOPMed-produced data, integrate multiple omics layers, and develop analytic methods, software, pipelines, and other resources that improve the ability of the broader scientific community to use TOPMed datasets.
What are examples of scientific outcomes this FOA is trying to enable?
The FOA emphasizes analyses that can clarify biological pathways, improve risk prediction, refine disease subtypes, or reveal targets relevant to prevention and treatment in heart, lung, blood, and sleep-related conditions.
What is the "TOPMed information commons" mentioned in the opportunity?
It refers to expanding shared, community-oriented resources built around TOPMed. In practical terms, it means producing not only findings, but also reusable analytic approaches, tools, pipelines, and resources that strengthen TOPMed as a shared ecosystem for advanced genomic and multi-omics research.
How does a U01 cooperative agreement affect how the work is carried out?
The description indicates the work is intended to be collaborative and coordinated with NHLBI and the larger TOPMed consortium, rather than operating as a fully independent, investigator-initiated project. This typically includes alignment with consortium standards for data use and sharing, participation in joint planning or working groups, and producing outputs that fit into shared consortium resources.
Is this opportunity focused more on publications or on tools and resources?
The opportunity emphasizes that deliverables are not just publications. There is a clear expectation of producing shareable outputs such as analytic methods, software, pipelines, and other reusable resources that help researchers interrogate TOPMed data.
What is the award ceiling for this opportunity?
The listed award ceiling is $400,000.
How many awards were anticipated?
The announcement anticipated making about 5 awards.
When was this FOA posted, and what were the closing dates?
The FOA was posted and created on April 18, 2016. The original and current closing date listed is July 6, 2016.
What is the funding activity category?
The opportunity is categorized under the health funding activity category.
Is this considered discretionary funding?
Yes. The opportunity is categorized as discretionary funding.
Which CFDA numbers are associated with this opportunity?
The opportunity references CFDA numbers 93.233, 93.837, 93.838, 93.839, and 93.840.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including: state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed by the FOA's additional eligibility language.
Are academic institutions eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible.
Are nonprofit organizations eligible?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible, with the noted exclusion that these nonprofit categories exclude higher education institutions.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are government entities eligible?
Yes. Eligible government entities include state, county, city or township governments, special district governments, and independent school districts.
Are Tribal entities eligible?
Yes. Federally recognized Native American tribal governments and other tribal organizations are listed as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible.
What kinds of expertise does this opportunity appear to target?
The description frames this as best suited for teams with capabilities in statistical genetics, computational biology, bioinformatics, multi-omics integration, and tool building, with an emphasis on scalable approaches for large genomic datasets.
What kinds of deliverables are expected to provide "consortium-wide value"?
The FOA description highlights outputs such as rigorous and reusable analytic methods, scalable strategies for working with large genomic datasets, and deliverables (including tools and derived resources) that can be shared and adopted by other researchers working in TOPMed and related efforts.
Does this FOA expect awardees to coordinate with a consortium?
Yes. The FOA explicitly describes close coordination with NHLBI and the larger TOPMed consortium, including engagement with program leadership, alignment with consortium standards, and participation in joint planning or working groups so outputs fit within a shared ecosystem.
What disease or research areas are in scope?
The scope centers on heart, lung, blood, and sleep disorders, consistent with NHLBI mission areas and the TOPMed program goals.
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