Opportunity Information: Apply for PA 11 078
Apply for PA 11 078
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 13, 2010 and posted on Dec 13, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00), Funding Opportunity Number PA-11-078, was a National Institutes of Health career development funding opportunity designed to help clinically trained researchers transition into independent careers focused on muscular dystrophy. It was sponsored by two NIH institutes, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The central goal was to expand and strengthen the pipeline of investigators who can pursue high-quality basic, translational, and clinical research on muscular dystrophies, while also building the kind of cross-disciplinary expertise increasingly needed to tackle complex research problems in this field.
The program specifically targeted “promising clinically trained applicants” who were engaged in laboratory research and who showed strong potential to become productive, independent investigators. The FOA emphasizes the need for highly skilled and interactive scientists capable of integrating multiple disciplines and levels of expertise. In practice, that framing reflects the reality that meaningful progress in muscular dystrophy often requires connecting insights from molecular and cellular biology to preclinical models, biomarkers, and ultimately clinical studies. The award therefore functioned as both a mentored career development experience and a structured pathway toward independence, with the expectation that awardees would emerge better prepared to lead their own research programs.
In terms of scientific scope, the opportunity supported research across the muscular dystrophy spectrum. The announcement explicitly mentions Duchenne muscular dystrophy, myotonic dystrophy, facioscapulohumeral muscular dystrophy (FSHD), and congenital muscular dystrophies, while also leaving room for additional muscular dystrophy conditions. The intent was not to narrow applicants to a single disease area but to encourage strong research programs that could contribute to understanding disease mechanisms, developing or improving therapeutic strategies, refining translational approaches, or strengthening clinical research directions relevant to muscular dystrophy.
Mechanistically, the FOA used the NIH K99 grant mechanism, which is part of the broader “Pathway to Independence” structure (commonly referred to as K99/R00). Although the text here highlights the K99 mechanism, the purpose of this mechanism is generally to support a mentored phase followed by a transition to an independent research phase, providing continuity as a clinician-scientist moves from training and mentorship into an autonomous position. This FOA was issued in parallel with other announcements of identical scientific scope that encouraged applications under additional NIH mechanisms, specifically F32, K08, and K23 (PA-11-075, PA-11-076, and PA-11-077), signaling an overall coordinated effort to strengthen training and career development in muscular dystrophy research across multiple career stages and applicant backgrounds.
From an administrative standpoint, this was a discretionary grant opportunity in the Health category (CFDA 93.846 for Arthritis, Musculoskeletal and Skin Diseases Research and CFDA 93.865 for Child Health and Human Development Extramural Research). It did not require cost sharing or matching. The announcement was posted and created on December 13, 2010, with an original and current closing date of January 7, 2014, and it was archived on February 7, 2014, meaning it is no longer an active solicitation but remains part of the historical NIH funding record.
Eligibility was broad and included a wide range of organization types that could serve as applicant institutions, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), state governments, federally recognized tribal governments, tribal organizations, small businesses, and other for-profit organizations (with small businesses called out separately). The FOA also explicitly included additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, eligible federal agencies, faith-based and community-based organizations, and U.S. territories or possessions. This broad eligibility structure is consistent with NIH’s general approach of allowing many institutional settings to host career development awards, provided the applicant meets program-specific requirements.
For applicants or institutions needing official details, the NIH provided an online full announcement link (http://grants.nih.gov/grants/guide/pa-files/PA-11-078.html). The contact information included the NIH Office of Extramural Research (OER) Webmaster for technical difficulties accessing or linking to the announcement (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00) - PA-11-078
What is PA-11-078?
PA-11-078 is the NIH Pathway to Independence Award in Muscular Dystrophy Research (K99/R00), a career development funding opportunity created to help clinically trained researchers move from mentored research into independent careers focused on muscular dystrophy.
Which NIH institutes sponsored this opportunity?
This funding opportunity was sponsored by two NIH institutes: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What was the main goal of the program?
The central goal was to expand and strengthen the pipeline of investigators capable of conducting high-quality basic, translational, and clinical research on muscular dystrophies, while building cross-disciplinary expertise needed to address complex problems in the field.
Who was the program designed for?
The program specifically targeted promising clinically trained applicants who were engaged in laboratory research and who demonstrated strong potential to become productive, independent investigators in muscular dystrophy research.
What kind of research approach did the FOA emphasize?
The FOA emphasized highly skilled and interactive scientists who can integrate multiple disciplines and levels of expertise, reflecting the need to connect molecular and cellular insights to preclinical models, biomarkers, and clinical studies in muscular dystrophy.
What types of muscular dystrophy were included in the scientific scope?
The announcement explicitly mentioned Duchenne muscular dystrophy, myotonic dystrophy, facioscapulohumeral muscular dystrophy (FSHD), and congenital muscular dystrophies, while also allowing for additional muscular dystrophy conditions.
Was the opportunity limited to a single disease area?
No. The intent was not to narrow applicants to one muscular dystrophy subtype, but to encourage strong research programs that could advance disease mechanisms, therapeutic strategies, translational approaches, or clinical research directions relevant to muscular dystrophy.
What funding mechanism did PA-11-078 use?
This FOA used the NIH K99 mechanism, part of the broader Pathway to Independence structure commonly referred to as K99/R00.
How does the Pathway to Independence (K99/R00) structure work at a high level?
Based on the description provided, the mechanism is generally intended to support a mentored phase followed by a transition to an independent research phase, helping provide continuity as a clinician-scientist moves from training and mentorship into an autonomous position.
Were there related NIH opportunities connected to this announcement?
Yes. PA-11-078 was issued in parallel with other announcements of identical scientific scope that encouraged applications under additional NIH mechanisms: F32, K08, and K23 (PA-11-075, PA-11-076, and PA-11-077). This reflects a coordinated effort to strengthen training and career development in muscular dystrophy research across multiple career stages.
What category and type of grant was this considered?
Administratively, this was a discretionary grant opportunity in the Health category.
What CFDA programs were associated with this opportunity?
The opportunity referenced CFDA 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and CFDA 93.865 (Child Health and Human Development Extramural Research).
Did the FOA require cost sharing or matching funds?
No. The announcement stated that cost sharing or matching was not required.
Is PA-11-078 still accepting applications?
No. The original and current closing date was January 7, 2014, and the opportunity was archived on February 7, 2014, meaning it is no longer an active solicitation.
When was the announcement created and posted?
The announcement was created and posted on December 13, 2010.
What were the key dates listed for the FOA?
Key dates included a posted/created date of December 13, 2010; an original and current closing date of January 7, 2014; and an archive date of February 7, 2014.
What types of organizations were eligible to apply as applicant institutions?
Eligibility included a broad set of organization types, such as public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), state governments, federally recognized tribal governments, tribal organizations, small businesses, and other for-profit organizations.
Did the eligibility list include specific institution categories like HBCUs or Hispanic-serving institutions?
Yes. The FOA explicitly included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and additional categories.
Were faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were explicitly included among the eligible applicants.
Were U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions were explicitly included among eligible applicants.
Where can someone find the official full announcement for PA-11-078?
The full NIH announcement link provided was: http://grants.nih.gov/grants/guide/pa-files/PA-11-078.html.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical difficulties accessing or linking to the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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