Opportunity Information: Apply for PA 16 077

  • The HHS-NIH11 in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award (Parent K99/R00)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.307, 93.321, 93.351, 93.361, 93.398, 93.837, 93.838, 93.839, 93.846, 93.847, 93.853, 93.855, 93.856, 93.859, 93.865, 93.866, 93.867, 93.879,.
  • This funding opportunity was created on Jan 08, 2016 and posted on Jan 08, 2016.
  • Applicants must submit their applications by May 07, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PA 16 077

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Opportunity Summary:

The NIH Pathway to Independence Award (Parent K99/R00), funding opportunity number PA-16-077, is a discretionary NIH grant mechanism designed to help outstanding postdoctoral researchers move into independent faculty careers as quickly and successfully as possible. Its central goal is to strengthen and sustain the pipeline of early-stage investigators by supporting the critical transition period between a mentored postdoctoral position and an independent, tenure-track (or equivalent) research appointment. In practical terms, the program is meant for highly promising postdocs who are ready to shift from working under a mentor to running their own research program, and it provides NIH-backed support to make that transition more stable and competitive.

The K99/R00 structure reflects the two-step career progression the program is trying to encourage. The first component (the K99 phase) supports a mentored period while the applicant is still in a postdoctoral role, allowing them to sharpen their research direction, publish, build skills, and prepare for independence under structured mentorship. The second component (the R00 phase) provides independent research support once the awardee secures an independent, tenure-track or equivalent faculty position. The intent is to reduce the funding gap that can occur when a researcher starts a faculty job but has not yet secured major independent research grants, giving awardees a stronger runway to launch a self-directed research program and compete successfully for longer-term NIH funding.

Administratively, this opportunity is offered by the Department of Health and Human Services through the National Institutes of Health (Agency: HHS-NIH11) and uses the grant funding instrument type. The funding activity category is broadly listed across areas that include education, environment, food and nutrition, health, income security, and social services, reflecting NIH's wide biomedical and behavioral research mission and the many institutes and centers that can participate. The opportunity is associated with multiple CFDA numbers (including 93.113, 93.121, 93.172, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.307, 93.321, 93.351, 93.361, 93.398, 93.837, 93.838, 93.839, 93.846, 93.847, 93.853, 93.855, 93.856, 93.859, 93.865, 93.866, 93.867, 93.879), which signals that many NIH components may use or align with this parent announcement depending on scientific area.

Eligibility is broadly open on the institutional side, spanning public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3) entities outside of higher education), for-profit organizations (other than small businesses), small businesses, and a range of government entities. These include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Eligible entities also include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments), along with an "others" category that points applicants to additional eligibility clarifications in the full announcement. While the listing emphasizes that many organization types can serve as applicants or host institutions, the program itself is fundamentally targeted at individual postdoctoral researchers with a research and/or clinical doctorate who are preparing for independent academic-style research careers.

Key dates in the provided record show an original and current closing date of May 7, 2016, with the opportunity created and posted on January 8, 2016. The provided data does not specify an award ceiling or expected number of awards, which typically means those details would need to be confirmed in the full funding opportunity announcement or through the relevant NIH institute or center participating in the parent mechanism. Overall, the K99/R00 is best understood as a transition award: it is not simply funding for a project, but a structured investment in a scientist's trajectory, pairing mentored development with a defined pathway to independent NIH research support once a faculty-level appointment is secured.

FAQs: NIH Pathway to Independence Award (Parent K99/R00) - PA-16-077

What is the NIH Pathway to Independence Award (Parent K99/R00)?

The NIH Pathway to Independence Award (Parent K99/R00), funding opportunity number PA-16-077, is an NIH grant mechanism designed to help outstanding postdoctoral researchers transition from mentored postdoctoral training into independent faculty careers as quickly and successfully as possible.

What is the central goal of the K99/R00 program?

The central goal is to strengthen and sustain the pipeline of early-stage investigators by supporting the critical transition period between a mentored postdoctoral position and an independent, tenure-track (or equivalent) research appointment.

Who is this opportunity intended to support?

This program is fundamentally targeted at individual postdoctoral researchers with a research and/or clinical doctorate who are preparing for independent academic-style research careers and are ready to move from working under a mentor to running their own research program.

How does the K99/R00 structure work?

The program is structured in two phases that reflect a two-step career progression: (1) the K99 phase supports a mentored postdoctoral period, and (2) the R00 phase provides independent research support after the awardee secures an independent, tenure-track or equivalent faculty position.

What does the K99 phase support?

The K99 phase supports a mentored period while the applicant remains in a postdoctoral role. It is intended to help the researcher sharpen their research direction, publish, build skills, and prepare for independence under structured mentorship.

What does the R00 phase support?

The R00 phase provides independent research support once the awardee obtains an independent, tenure-track (or equivalent) research appointment. The purpose is to help launch a self-directed research program and improve competitiveness for longer-term NIH funding.

Why does NIH provide funding across two phases instead of one?

The two-phase design is intended to reduce the funding gap that can occur when a researcher starts a faculty job but has not yet secured major independent research grants. The K99 phase supports mentored preparation, and the R00 phase provides a more stable runway to start an independent program.

Is this award mainly funding for a research project or a career transition?

Based on the description provided, the K99/R00 is best understood as a transition award. It is a structured investment in a scientist's trajectory that pairs mentored development with a defined pathway to independent NIH research support.

Which federal agency offers this opportunity?

This opportunity is offered by the Department of Health and Human Services through the National Institutes of Health (NIH). The agency is listed as HHS-NIH11.

What type of funding instrument is used?

The opportunity uses the grant funding instrument type.

What is the funding opportunity number for this announcement?

The funding opportunity number is PA-16-077.

What activity areas or mission categories are associated with this opportunity?

The funding activity category is broadly listed across areas including education, environment, food and nutrition, health, income security, and social services, reflecting NIH's broad biomedical and behavioral research mission and the many NIH institutes and centers that may participate.

What CFDA numbers are associated with this opportunity, and what do they imply?

This opportunity is associated with multiple CFDA numbers (including 93.113, 93.121, 93.172, 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.307, 93.321, 93.351, 93.361, 93.398, 93.837, 93.838, 93.839, 93.846, 93.847, 93.853, 93.855, 93.856, 93.859, 93.865, 93.866, 93.867, 93.879). This signals that many NIH components may use or align with the parent announcement depending on the scientific area.

What types of institutions are eligible on the organizational side?

Eligibility is broadly open to many organization types, including public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3) entities outside of higher education); for-profit organizations (other than small businesses); small businesses; and various government entities.

Which government entities are listed as eligible?

The eligible government entities listed include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.

Are Native American tribal entities listed as eligible?

Yes. The eligible entities include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments).

Does broad institutional eligibility change who the program is really aimed at?

Even though many organization types can serve as applicants or host institutions, the program itself is described as fundamentally targeted at individual postdoctoral researchers who are preparing for independent research careers.

What does "tenure-track (or equivalent)" mean in the context of the R00 phase?

In the context provided, it refers to an independent, faculty-level (or equivalent) research appointment required to move into the R00 phase. The description emphasizes independence rather than a specific job title.

What are the key dates shown for this opportunity?

The opportunity was created and posted on January 8, 2016. The record lists an original and current closing date of May 7, 2016.

Is an award ceiling provided in the information given?

No. The provided data does not specify an award ceiling.

Is the expected number of awards provided in the information given?

No. The provided data does not specify the expected number of awards.

Where would an applicant typically look for missing details like award size or number of awards?

Based on the information provided, those details would typically need to be confirmed in the full funding opportunity announcement or through the relevant NIH institute or center participating in the parent mechanism.

What problem is the K99/R00 intended to address for early-career researchers?

It is intended to address the vulnerable transition period between postdoctoral mentorship and independent faculty research, including the potential funding gap that can occur when starting a faculty position without having major independent research grants in place.

What does it mean that this is a "Parent" K99/R00 announcement?

From the information provided, "Parent" indicates that multiple NIH institutes and centers may participate or align with this mechanism depending on the scientific area, rather than it being limited to a single NIH component.

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Applicants also applied for:

Applicants who have applied for this opportunity (PA 16 077) also looked into and applied for these:

Funding Opportunity
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 16 152

Funding Number: PA 16 152
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
NIH Research Project Grant (Parent R01) Apply for PA 16 160

Funding Number: PA 16 160
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
NIH Exploratory/Developmental Research Grant Program (Parent R21) Apply for PA 16 161

Funding Number: PA 16 161
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Mentored Patient-Oriented Research Career Development Award (Parent K23) Apply for PA 16 198

Funding Number: PA 16 198
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Mentored Clinical Scientist Research Career Development Award (Parent K08) Apply for PA 16 191

Funding Number: PA 16 191
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
NIH Pathway to Independence Award (Parent K99/R00) Apply for PA 16 193

Funding Number: PA 16 193
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Lasker Clinical Research Scholars Program (Si2/R00) Apply for PAR 16 203

Funding Number: PAR 16 203
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Academic Research Enhancement Award (Parent R15) Apply for PA 16 200

Funding Number: PA 16 200
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: $300,000
Mentored Quantitative Research Development Award (Parent K25) Apply for PA 16 194

Funding Number: PA 16 194
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
BD2K Mentored Career Development Award in Biomedical Big Data Science for Intramural Investigators (K22) Apply for RFA ES 16 003

Funding Number: RFA ES 16 003
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
BD2K Mentored Career Development Award in Biomedical Big Data Science for Clinicians and Doctorally Prepared Scientists (K01) Apply for RFA ES 16 002

Funding Number: RFA ES 16 002
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
BD2K Predoctoral Training in Biomedical Big Data Science (T32) Apply for RFA LM 16 002

Funding Number: RFA LM 16 002
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
BD2K Open Educational Resources for Skills Development in Biomedical Big Data Science (R25) Apply for RFA HG 16 016

Funding Number: RFA HG 16 016
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: $200,000
Change of Grantee Organization (Type 7 Parent) Apply for PA 16 285

Funding Number: PA 16 285
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Successor-in-Interest (Type 6 Parent) Apply for PA 16 286

Funding Number: PA 16 286
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp) Apply for PA 16 288

Funding Number: PA 16 288
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) Apply for PA 16 289

Funding Number: PA 16 289
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
NIH Support for Conferences and Scientific Meetings (Parent R13) Apply for PA 16 294

Funding Number: PA 16 294
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) Apply for PA 16 303

Funding Number: PA 16 303
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent
Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship for Students at Institutions With NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 16 305

Funding Number: PA 16 305
Agency: HHS-NIH11
Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Funding Amount: Case Dependent

 

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