Opportunity Information: Apply for RFA RM 14 003
Apply for RFA RM 14 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Transformative Research Awards (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Jul 24, 2014 and posted on Jul 24, 2014.
- Applicants must submit their applications by Oct 10, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $15,000,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities City or township governments For profit organizations other than small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Transformative Research Awards (R01) funding opportunity (RFA-RM-14-003) is a discretionary NIH grant program designed to back research ideas that are genuinely bold and unconventional, especially proposals that may not fit neatly into traditional investigator-initiated mechanisms. The core aim is to support individual scientists or teams pursuing work that is groundbreaking and exceptionally innovative, with the potential to reshape how a field thinks about a problem. NIH frames the intended outcomes in big terms: creating new scientific paradigms, establishing entirely new or substantially improved clinical approaches, or developing technologies that could be truly transformative. A key feature of this opportunity is that little or no preliminary data are expected, which signals that the program is meant to take on high-risk, high-reward concepts where strong rationale, originality, and potential impact matter more than extensive prior results.
In terms of scope, projects must show clear potential for major impact across a broad area of biomedical or behavioral research. That emphasis on broad impact is important: the program is not just looking for incremental improvements or narrow extensions of existing work, but rather ideas that could change the trajectory of a research area or open up entirely new directions. The “transformative†label is meant literally, and applicants are expected to make a convincing case that their approach is not only novel, but capable of producing outsized advances relative to typical R01-style projects.
The opportunity was posted on July 24, 2014, with an original and current closing date of October 10, 2014, and an archive date of November 10, 2014. NIH listed an estimated total funding amount of $15,000,000 for this announcement, with an award ceiling also stated as $15,000,000. The funding instrument type is a grant, and the funding activity category is health. The CFDA number associated with the program is 93.310 (Trans-NIH Research Support). There is no cost sharing or matching requirement, meaning applicants are not required to commit non-federal matching funds as a condition of eligibility or award.
Eligibility is broad and spans many organization types, reflecting NIH’s interest in sourcing transformative ideas from a wide range of institutional settings. Eligible applicants include federal, state, county, city or township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (including those other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. Additional eligible categories called out include historically underserved and mission-specific institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). Faith-based or community-based organizations and eligible federal agencies are also included in the eligibility language, along with certain regional organizations and U.S. territories or possessions.
At the same time, the announcement makes clear limits on non-U.S. participation. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic components of U.S. organizations are not eligible to apply. However, “foreign components,†as defined by the NIH Grants Policy Statement, are allowed, which generally means a U.S.-based applicant organization may include certain foreign activities or collaborations when justified and consistent with NIH policy, even though a foreign institution cannot be the applicant.
The sponsoring agency is the National Institutes of Health. For full details, NIH provided an additional information link to the official NIH funding announcement page: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-003.html. For access or technical issues with the announcement, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, including support for difficulty accessing the full announcement electronically or problems linking to the funding notice.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH Transformative Research Awards (R01) funding announcement, RFA-RM-14-003. It is a discretionary NIH grant program intended to support research ideas that are genuinely bold, unconventional, and potentially field-changing.
What is the main goal of the NIH Transformative Research Awards program?
The core aim is to support individual scientists or teams proposing exceptionally innovative work with the potential to reshape how a field approaches a problem. NIH describes intended outcomes in large, transformative terms, such as creating new scientific paradigms, establishing entirely new or substantially improved clinical approaches, or developing technologies that could be truly transformative.
What makes this program different from more traditional investigator-initiated mechanisms?
This program is designed for proposals that may not fit neatly into traditional investigator-initiated mechanisms. It explicitly focuses on high-risk, high-reward concepts where originality, rationale, and potential impact are emphasized over extensive prior results.
Is preliminary data required to apply?
No. A key feature of this opportunity is that little or no preliminary data are expected, reflecting the program's intent to back early, high-risk ideas when the case for originality and potential impact is compelling.
What type of projects are in scope for this opportunity?
Projects must show clear potential for major impact across a broad area of biomedical or behavioral research. The emphasis is on transformative ideas rather than incremental improvements or narrow extensions of existing work.
What does NIH mean by "transformative" in this context?
"Transformative" is meant literally: applicants are expected to argue that the approach is not only novel, but capable of producing outsized advances relative to typical R01-style projects, potentially changing the trajectory of a research area or opening new directions.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What is the funding instrument type?
The funding instrument type is a grant.
What is the activity category for this opportunity?
The funding activity category is health.
What is the CFDA number associated with this program?
The CFDA number is 93.310 (Trans-NIH Research Support).
How much funding is available under this announcement?
NIH listed an estimated total funding amount of $15,000,000 for this announcement. An award ceiling of $15,000,000 is also stated in the opportunity information provided.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to commit non-federal matching funds as a condition of eligibility or award.
When was the opportunity posted?
The opportunity was posted on July 24, 2014.
What was the closing date for applications?
The original and current closing date listed is October 10, 2014.
When was (or is) the archive date?
The archive date listed is November 10, 2014.
What types of organizations are eligible to apply?
Eligibility is broad and includes many organization types, such as:
- Federal, state, county, city or township, and special district governments
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Independent school districts
- Public housing authorities and Indian housing authorities
- Nonprofits with and without 501(c)(3) status (including those other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
Are historically underserved or mission-specific institutions included in eligibility?
Yes. The eligibility language specifically includes institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the eligibility language provided.
Are U.S. territories or possessions included in eligible applicant categories?
Yes. Certain regional organizations and U.S. territories or possessions are included in the eligibility language provided.
Can foreign (non-U.S.) organizations apply as the applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic components of U.S. organizations are not eligible to apply as the applicant organization.
Are any international activities allowed under this opportunity?
Yes. "Foreign components," as defined by the NIH Grants Policy Statement, are allowed. This generally means a U.S.-based applicant organization may include certain foreign activities or collaborations when justified and consistent with NIH policy, even though a foreign institution cannot be the applicant.
Where can applicants find the official NIH funding announcement?
NIH provided an official announcement link here: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-003.html.
Who should be contacted for access or technical issues with the announcement?
For difficulty accessing the full announcement electronically or problems linking to the funding notice, NIH listed the NIH Office of Extramural Research (OER) Webmaster as the contact: FBOWebmaster@OD.NIH.GOV.
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