Opportunity Information: Apply for RFA RM 13 008

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Transformative Research Awards (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
  • This funding opportunity was created on Oct 18, 2013 and posted on Jul 26, 2013.
  • Applicants must submit their applications by Nov 1, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
  • Eligible applicants include: State governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments County governments Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The NIH Transformative Research Awards (R01) opportunity (Funding Opportunity Number RFA-RM-13-008) is a discretionary grant program run by the National Institutes of Health that supports high-impact, high-risk research projects in the health arena. It uses the NIH R01 grant mechanism, but it is framed specifically around "transformative" ideas, meaning proposals are expected to aim well beyond incremental advances and instead pursue approaches that could meaningfully change how a problem is understood, studied, prevented, diagnosed, or treated. The funding activity category is Health, and it is associated with CFDA 93.310 (Trans-NIH Research Support), which signals that the program is intended to cut across NIH institutes and centers rather than live entirely within a single disease or organ-focused silo.

The total estimated funding available under this announcement is $15,000,000, and the program does not require cost sharing or matching. This is useful for applicants because it reduces the financial burden on the institution and allows investigators to focus the proposed budget on the science and the resources needed to pursue unusually bold research directions. Like many NIH opportunities, the emphasis is on research ideas and scientific merit, but the "transformative" label generally indicates that reviewers are looking for proposals with the potential to disrupt existing paradigms, open entirely new avenues of inquiry, or overcome entrenched technical barriers.

Eligibility is broad and includes a wide range of domestic organizations across the public, private, nonprofit, and educational sectors. Eligible applicants include state governments, county governments, city or township governments, special district governments, and public housing authorities or Indian housing authorities. Academic institutions are eligible as well, including public and state-controlled institutions of higher education and private institutions of higher education, along with independent school districts. The opportunity is also open to nonprofits both with and without 501(c)(3) status (as long as they are not institutions of higher education in the non-501(c)(3) category), as well as for-profit organizations, including small businesses and other for-profit entities that are not small businesses. Tribal participation is explicitly supported through eligibility for federally recognized Native American tribal governments and for tribal organizations that are not federally recognized.

The announcement also clarifies additional eligible applicant types, emphasizing inclusion of institutions that serve historically underrepresented populations and a variety of community-based entities. This includes Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based or community-based organizations are listed as eligible, as are regional organizations, U.S. territories or possessions, and eligible federal agencies. On the other hand, foreign institutions are not eligible to apply directly as non-domestic entities, and non-domestic components of U.S. organizations are also not eligible to apply. However, the announcement allows "foreign components" as defined under the NIH Grants Policy Statement, meaning a U.S.-based applicant may include certain scientifically justified international elements within the project when appropriate and allowable under NIH rules.

In terms of timing and status, the opportunity was posted on July 26, 2013, created on October 18, 2013, and originally had a closing date of October 4, 2013. The current listed closing date was November 1, 2013, and the archive date is December 1, 2013, meaning it is no longer an active competition and has been moved into NIH's archived records. The primary source link for the full announcement is hosted on the NIH grants website at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-008.html, which is where applicants would have found the complete requirements, review criteria, and submission instructions when the opportunity was open.

For support and technical access issues related to the announcement, NIH directs users to contact the NIH Office of Extramural Research (OER) Webmaster. Two contact routes are provided: one for difficulty accessing the full announcement electronically and another for problems linking to the funding announcement, both pointing to the same email address (FBOWebmaster@OD.NIH.GOV). This is largely administrative help rather than scientific program guidance, but it is the designated point of contact listed in the source data for access and linking issues.

NIH Transformative Research Awards (R01) (RFA-RM-13-008) FAQs

What is the NIH Transformative Research Awards (R01) opportunity?

The NIH Transformative Research Awards (R01) opportunity (Funding Opportunity Number RFA-RM-13-008) is a discretionary National Institutes of Health (NIH) grant program that supports high-impact, high-risk health research projects. While it uses the standard NIH R01 mechanism, it is specifically framed around "transformative" ideas rather than incremental advances.

What does "transformative" mean in this funding opportunity?

In this announcement, "transformative" indicates proposals are expected to go well beyond incremental progress and instead pursue approaches that could meaningfully change how a health problem is understood, studied, prevented, diagnosed, or treated. The aim is work that could disrupt existing paradigms, open new avenues of inquiry, or overcome entrenched technical barriers.

What type of grant mechanism is used?

This opportunity uses the NIH R01 grant mechanism.

What is the funding activity category?

The funding activity category is Health.

What CFDA number is associated with this opportunity, and what does it imply?

The opportunity is associated with CFDA 93.310 (Trans-NIH Research Support). This signals the program is intended to cut across NIH institutes and centers, rather than being limited to a single disease-area or organ-focused institute.

How much total funding was estimated to be available?

The total estimated funding available under this announcement is $15,000,000.

Is cost sharing or matching required?

No. The program does not require cost sharing or matching.

What kinds of organizations are eligible to apply?

Eligibility is broad and includes many types of domestic organizations across public, private, nonprofit, and educational sectors. Examples listed in the announcement include:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Public housing authorities or Indian housing authorities
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Independent school districts
  • Nonprofits with 501(c)(3) status
  • Nonprofits without 501(c)(3) status (as long as they are not institutions of higher education within that non-501(c)(3) category)
  • For-profit organizations (including small businesses and other for-profit entities that are not small businesses)
  • Federally recognized Native American tribal governments
  • Tribal organizations that are not federally recognized

Are organizations that serve historically underrepresented populations specifically included?

Yes. The announcement explicitly lists several institution types that serve historically underrepresented populations as eligible, including:

  • Historically Black Colleges and Universities (HBCUs)
  • Hispanic Serving Institutions
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs)

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are listed as eligible applicant types.

Are regional organizations eligible?

Yes. Regional organizations are listed as eligible.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed as eligible.

Are federal agencies eligible to apply?

Yes. Eligible federal agencies are included among the eligible applicant types.

Are foreign institutions eligible to apply directly?

No. Foreign institutions are not eligible to apply directly as non-domestic entities under this announcement.

Are non-domestic components of U.S. organizations eligible to apply?

No. Non-domestic components of U.S. organizations are also not eligible to apply.

Can a U.S.-based applicant include international work in the project?

Yes, in a limited way. While foreign institutions cannot apply directly and non-domestic components of U.S. organizations cannot apply, the announcement allows "foreign components" as defined under the NIH Grants Policy Statement when they are scientifically justified and allowable under NIH rules.

When was this funding opportunity posted and created?

The opportunity was posted on July 26, 2013, and created on October 18, 2013.

What were the closing dates for this opportunity?

The announcement originally had a closing date of October 4, 2013. The current listed closing date is November 1, 2013.

Is this opportunity still active?

No. The archive date is December 1, 2013, which indicates it is no longer an active competition and has been moved into NIH's archived records.

Where can the full announcement be found?

The primary source link for the full announcement is hosted on the NIH grants website at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-008.html. When the opportunity was open, this page would have contained the full requirements, review criteria, and submission instructions.

Who do I contact if I cannot access the announcement or have linking issues?

NIH directs users with technical access issues or linking problems to contact the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. The same email address is provided for both types of issues.

Is the listed contact intended for scientific or program guidance?

No. The contact information provided in the source data is for administrative/technical support related to accessing the announcement electronically or resolving linking issues, not for scientific program guidance.

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