Opportunity Information: Apply for RFA AI 09 041
Apply for RFA AI 09 041
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Non Human Primate Heart/Lung Transplantation Tolerance (U01, U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research.
- This funding opportunity was created on Aug 14, 2009 and posted on Aug 14, 2009.
- Applicants must submit their applications by Dec 17, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public and State controlled institutions of higher education Private institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) County governments Special district governments Small businesses Public housing authorities/Indian housing authorities State governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This funding opportunity (RFA AI 09 041) is a National Institutes of Health award run through the National Institute of Allergy and Infectious Diseases (NIAID) focused specifically on non human primate (NHP) heart and lung transplantation research. It sits within a long-running, multi-center program called the Non Human Primate Transplantation Tolerance Cooperative Study Group (NHPCSG). The core idea behind NHPCSG is to use rigorous NHP transplant models to test whether immune tolerance strategies can be made safe, effective, and durable enough to ultimately improve outcomes in human clinical transplantation. In practical terms, the program is trying to reduce or eliminate the need for lifelong immunosuppression by developing regimens that teach the recipient immune system to accept the graft long term, and by understanding why tolerance is achieved in some settings but breaks down in others.
The NHPCSG itself was established in 1999 and spans multiple transplant model systems, including kidney, islet, heart, and lung. This particular announcement is narrowly aimed at renewing (and also accepting new) projects that cover the heart and lung model portion of that larger cooperative study group. Applicants are expected to contribute to preclinical evaluation of both existing and newly developed tolerance induction regimens and to investigate the underlying biology: how tolerance is induced, how it is maintained, and what mechanisms lead to loss of tolerance or rejection over time. The long-range deliverable is translational: tolerance approaches that can realistically support better long-term graft survival and patient outcomes in clinical heart and lung transplantation.
The awards are offered as cooperative agreements rather than standard research grants, meaning NIAID expects an active partnership role in how the work is coordinated and carried out across the program. Two cooperative agreement mechanisms are available: the U01 (single-project) mechanism for focused, standalone projects, and the U19 (multi-project) mechanism for integrated, multi-component efforts that typically include multiple interrelated projects under one umbrella. Because this is a cooperative, multi-center program, awardees should expect a higher degree of coordination, shared standards, and collaborative planning than in a typical investigator-initiated grant, consistent with the goal of generating comparable, program-level conclusions from NHP transplant studies.
On funding, NIAID anticipated making two to three awards using about $2,000,000 in total costs in fiscal year 2010. The announcement also makes clear that the actual awards depend on the availability of appropriated funds and on receiving enough applications that score well and are judged meritorious. In other words, the budget and award count are planned targets, but not guarantees.
The opportunity is categorized as discretionary funding and falls under the health activity category, with CFDA number 93.855 (Allergy, Immunology and Transplantation Research). There is no cost sharing or matching requirement stated for applicants, which generally lowers the administrative barrier for eligible organizations.
Eligibility is broad and includes a wide range of domestic institutions and organizations that could plausibly support sophisticated NHP transplantation research and collaborative program participation. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and many levels of government (state, county, city/township, special district), as well as independent school districts and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes various mission-focused and underserved-institution categories, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, U.S. territories or possessions, and certain tribal governments and tribal organizations (including categories beyond federally recognized tribal governments). Faith-based or community-based organizations and eligible federal agencies are also listed among eligible applicants, reflecting NIH’s standard broad eligibility framework when the scientific and infrastructure requirements can be met.
In terms of timing, the FOA was posted on August 14, 2009, with a closing date that ultimately reflected December 17, 2009 (with an original closing date listed as December 23, 2009). The archive date is January 17, 2010, indicating it is no longer active as a current application call, though it remains relevant as a record of program priorities and structure. The official full announcement was hosted on the NIH grants site, and the contact note provided points applicants to the NIH Office of Extramural Research (OER) webmaster for technical access issues rather than a scientific program contact in the excerpted text.
Overall, this FOA is best understood as a targeted renewal and expansion point for a long-standing NIAID-run cooperative network focused on tolerance induction in NHP transplantation, with this specific call emphasizing heart and lung models. The scientific emphasis is both translational and mechanistic: demonstrate preclinical safety and efficacy of tolerance regimens in stringent NHP heart/lung transplant settings, while also producing clear mechanistic insight into how tolerance is created, sustained, and lost, all within a coordinated, multi-center framework designed to accelerate progress toward clinically viable strategies.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This funding opportunity (RFA AI 09 041) is a National Institutes of Health (NIH) award run through the National Institute of Allergy and Infectious Diseases (NIAID). It supports research focused on non human primate (NHP) heart and lung transplantation within a coordinated, multi-center cooperative program.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), which is part of the NIH.
What program is this FOA part of?
It sits within the Non Human Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), a long-running, multi-center program established in 1999.
What is the overall goal of the NHPCSG program?
The core goal is to use rigorous NHP transplant models to test whether immune tolerance strategies can be made safe, effective, and durable enough to improve outcomes in human clinical transplantation. A key practical aim is reducing or eliminating the need for lifelong immunosuppression by developing regimens that promote long-term acceptance of the graft.
What transplant models does the broader NHPCSG program cover?
The broader NHPCSG spans multiple transplant model systems, including kidney, islet, heart, and lung models.
What is the scientific focus of this particular announcement?
This particular announcement is narrowly aimed at the heart and lung model portion of the NHPCSG. It is intended to renew existing projects and also accept new projects specifically addressing NHP heart and lung transplantation tolerance research.
What kinds of research activities are applicants expected to propose?
Applicants are expected to contribute to (1) preclinical evaluation of both existing and newly developed tolerance induction regimens in NHP heart and lung transplant models and (2) mechanistic studies that explain how tolerance is induced and maintained, and what causes tolerance to be lost (leading to rejection) over time.
Is this opportunity more translational, more basic science, or both?
Both. The emphasis is translational (moving toward tolerance approaches that could realistically improve long-term clinical heart and lung transplant outcomes) while also requiring mechanistic insight into the biology of tolerance and rejection.
What is meant by "immune tolerance" in the context of this FOA?
In this context, immune tolerance refers to strategies intended to "teach" the recipient immune system to accept a transplanted organ long term, ideally reducing or removing the need for lifelong immunosuppressive drugs.
Why are non human primate (NHP) models emphasized?
The NHPCSG is built around rigorous NHP transplant models as stringent preclinical systems for evaluating tolerance strategies and generating program-level conclusions that can inform clinical transplantation.
What award mechanisms are available under this FOA?
Two cooperative agreement mechanisms are available: U01 (single-project) for focused, standalone projects, and U19 (multi-project) for integrated, multi-component efforts with multiple interrelated projects under one umbrella.
How is a cooperative agreement different from a standard research grant?
This FOA uses cooperative agreements rather than standard research grants, meaning NIAID expects an active partnership role in coordinating and carrying out the work across the program. Awardees should anticipate more coordination, shared standards, and collaborative planning than with typical investigator-initiated grants.
How collaborative is the expected research structure?
Because this is a cooperative, multi-center program, projects are expected to align with shared standards and coordinated planning to support comparable results and program-level conclusions across NHP transplant studies.
How many awards did NIAID anticipate making?
NIAID anticipated making two to three awards.
What total funding level was anticipated?
NIAID anticipated using about $2,000,000 in total costs in fiscal year (FY) 2010.
Is the anticipated number of awards or total funding guaranteed?
No. The announcement notes that actual awards depend on the availability of appropriated funds and on receiving enough applications that score well and are judged meritorious.
What is the CFDA number and program classification?
The opportunity is listed under CFDA number 93.855, titled "Allergy, Immunology and Transplantation Research."
What type of funding category is this?
It is categorized as discretionary funding and falls under the health activity category.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated in the provided information.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; and many levels of government (state, county, city/township, and special district). Independent school districts and public housing authorities/Indian housing authorities are also included.
Are underserved or mission-focused institutions explicitly included as eligible?
Yes. The eligibility language explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, U.S. territories or possessions, and certain tribal governments and tribal organizations (including categories beyond federally recognized tribal governments).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are listed among eligible applicants.
When was the FOA posted?
The FOA was posted on August 14, 2009.
What was the application closing date?
The closing date ultimately reflected December 17, 2009. The information also notes an original closing date listed as December 23, 2009.
Is this FOA still active?
No. The archive date is January 17, 2010, which indicates it is no longer active as a current application call.
Where was the official full announcement hosted?
The official full announcement was hosted on the NIH grants site.
Who should be contacted for technical issues accessing the announcement?
The contact note provided points applicants to the NIH Office of Extramural Research (OER) webmaster for technical access issues.
Does the provided excerpt include a scientific or programmatic contact?
No. In the provided text, the contact note is for technical access issues rather than a scientific program contact.
What is the long-range deliverable expected from funded projects?
The long-range deliverable is translational: tolerance approaches that can realistically support better long-term graft survival and patient outcomes in clinical heart and lung transplantation, supported by strong preclinical evidence and mechanistic understanding from NHP studies.
What distinguishes this FOA from a typical investigator-initiated transplant grant?
This FOA is a targeted renewal/expansion point within a long-standing NIAID-run cooperative network (NHPCSG), emphasizing coordinated multi-center work, shared standards, and active NIAID partnership, with a narrow focus on NHP heart and lung tolerance models.
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