Opportunity Information: Apply for PA 14 171
Apply for PA 14 171
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Apr 4, 2014 and posted on Apr 4, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
The funding opportunity titled "Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (R41/R42)" (Funding Opportunity Number PA 14-171) is an NIH grant announcement that was designed to support early-stage and follow-on Small Business Technology Transfer (STTR) projects aimed at expanding the research toolbox for studying brain-localized G protein coupled receptors (GPCRs). In practical terms, the program is looking for small businesses, working in formal partnership with a research institution, to build or significantly improve technologies that make it easier to understand how GPCRs in the brain are built (their structure), how they work (their function), and how they might be manipulated in a highly selective way in the context of mental health.
A central theme of the FOA is technology development rather than basic discovery for its own sake. The announcement encourages applicants to create novel tools or novel ways of using existing tools that enable researchers to probe GPCR biology in the brain more effectively. This can include methods to interrogate receptor structure and conformational changes, platforms to measure receptor signaling in relevant neural cell types, and approaches that better capture the complexity of GPCR behavior in brain tissue or brain-like experimental systems. The FOA also highlights interest in technologies that can support the identification of new agonists or antagonists that are selective and specific for particular GPCR subtypes, reflecting the broader need for better chemical probes and potential therapeutic starting points.
The mental health angle is explicit: the technology should be relevant to understanding mental health function or dysfunction. The announcement also specifically includes HIV-related neurocognitive disorders as an area of interest, meaning projects that help illuminate GPCR roles in cognitive, behavioral, or neuropsychiatric complications associated with HIV are within scope. Importantly, the FOA notes that tools aimed at both well-characterized receptor subtypes and orphan receptors are of potential interest to the National Institute of Mental Health (NIMH). That matters because orphan GPCRs, which lack well-defined endogenous ligands or functions, represent a large and still underexplored portion of GPCR biology and could open up new avenues in psychiatric and neurocognitive research if better methods for studying them are developed.
From an administrative standpoint, this is a discretionary NIH grant opportunity under the STTR mechanism using the R41/R42 activity codes, which typically correspond to a phased approach: Phase I (R41) is generally focused on establishing feasibility and proof of concept, while Phase II (R42) supports further development and validation toward a more mature, usable product or platform. The funding instrument type is a grant, and the activity category is Health, with the CFDA number listed as 93.242 (Mental Health Research Grants). The FOA indicates there is no cost sharing or matching requirement, which lowers the barrier for small businesses that might not have the resources to provide substantial matching funds.
Eligibility is limited to small businesses, consistent with STTR requirements. Foreign institutions are not eligible to apply as applicants, and non-U.S. components of U.S. organizations are also not eligible to apply. However, the FOA notes that foreign components, as defined in the NIH Grants Policy Statement, may be allowed, which can sometimes permit discrete parts of the work to be conducted abroad if properly justified and compliant with NIH policy.
Key dates included a posted and creation date of April 4, 2014, with an original and current closing date of May 7, 2017, and an archive date of June 7, 2017. In other words, this specific announcement is archived and is not an active open solicitation today, but it remains useful as a reference point for the kind of GPCR-focused tool development priorities NIMH has supported through STTR mechanisms.
For those seeking the original full text, the FOA points to the NIH Guide link at http://grants.nih.gov/grants/guide/pa-files/PA-14-171.html. The contact listed for access or linking problems is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV), which is primarily a technical contact rather than a scientific program contact.
FAQs: Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (R41/R42) (PA-14-171)
What is the title and funding opportunity number for this grant?
The funding opportunity is titled "Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (R41/R42)" and the Funding Opportunity Number is PA-14-171.
What agency runs this funding opportunity?
This is a National Institutes of Health (NIH) grant announcement, with interests aligned to the National Institute of Mental Health (NIMH) based on the described priorities.
What is the overall purpose of PA-14-171?
The purpose is to support small business technology development that expands the research toolbox for studying brain-localized G protein coupled receptors (GPCRs) in the context of mental health research. The emphasis is on building or significantly improving technologies that help researchers understand GPCR structure, function, and selective manipulation in brain-relevant systems.
Is this opportunity focused on technology development or basic discovery research?
The central theme is technology development rather than basic discovery for its own sake. The FOA encourages novel tools, or novel ways of using existing tools, that enable more effective investigation of GPCR biology in the brain.
What kinds of tools or technologies does the FOA encourage?
Examples described include technologies to interrogate receptor structure and conformational changes, platforms to measure receptor signaling in relevant neural cell types, and approaches that better capture the complexity of GPCR behavior in brain tissue or brain-like experimental systems.
Does the FOA support work related to finding GPCR agonists or antagonists?
Yes. The announcement highlights interest in technologies that can support the identification of new agonists or antagonists that are selective and specific for particular GPCR subtypes, reflecting the need for better chemical probes and potential therapeutic starting points.
How is "mental health relevance" addressed in this announcement?
The FOA explicitly states that the technology should be relevant to understanding mental health function or dysfunction. In other words, tool development should connect to mental health research needs rather than being purely technical without mental health application.
Are HIV-related neurocognitive disorders within scope?
Yes. The FOA specifically includes HIV-related neurocognitive disorders as an area of interest, including tools that help illuminate GPCR roles in cognitive, behavioral, or neuropsychiatric complications associated with HIV.
Are projects on orphan GPCRs considered responsive?
Yes. The FOA notes that tools aimed at both well-characterized receptor subtypes and orphan receptors are of potential interest to NIMH. Orphan GPCRs are described as underexplored and potentially important for opening new avenues in psychiatric and neurocognitive research if better methods are developed.
What funding mechanism does PA-14-171 use?
The opportunity uses the NIH Small Business Technology Transfer (STTR) mechanism with activity codes R41/R42.
What do R41 and R42 generally mean in this FOA?
They reflect a phased approach typical of STTR: Phase I (R41) is generally focused on feasibility and proof of concept, while Phase II (R42) supports further development and validation toward a more mature, usable product or platform.
What is the funding instrument type?
The funding instrument type is a grant.
What is the activity category and CFDA number listed?
The activity category is Health, and the CFDA number listed is 93.242 (Mental Health Research Grants).
Is cost sharing or matching required?
No. The FOA indicates there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with STTR requirements, and applicants are expected to work in a formal partnership with a research institution.
Are foreign institutions eligible to apply as the applicant organization?
No. Foreign institutions are not eligible to apply as applicants under this FOA.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The FOA states that non-U.S. components of U.S. organizations are also not eligible to apply.
Can any part of the work be done outside the United States?
The FOA notes that foreign components, as defined in the NIH Grants Policy Statement, may be allowed. This suggests that discrete parts of the project may be conducted abroad if properly justified and compliant with NIH policy, even though foreign institutions cannot be the applicant.
Is this FOA currently open for applications?
No. The FOA is archived. The original and current closing date listed is May 7, 2017, and the archive date is June 7, 2017.
What were the key dates for this opportunity?
The posted and creation date was April 4, 2014. The original and current closing date was May 7, 2017. The archive date was June 7, 2017.
Where can applicants find the original NIH Guide announcement text?
The FOA points to the NIH Guide link: http://grants.nih.gov/grants/guide/pa-files/PA-14-171.html
Who is the listed contact and what is it for?
The contact listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV), and it is described as a technical contact for access or linking problems rather than a scientific program contact.
What is the practical goal of projects supported by this FOA?
In practical terms, the FOA seeks small businesses, partnered with a research institution, that will build or significantly improve technologies that make it easier to study how brain GPCRs are built (structure), how they work (function), and how they can be manipulated in a highly selective way in mental health research contexts.
Does the FOA limit interest to only well-known GPCR subtypes?
No. It explicitly notes interest in tools for both well-characterized receptor subtypes and orphan receptors.
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