Opportunity Information: Apply for PA 06 375
Apply for PA 06 375
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (SBIR R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Jan 26, 2009 and posted on Apr 28, 2006.
- Applicants must submit their applications by Jan 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are not eligible to apply. The NIH will accept as many different applications as the applicant organization chooses. However, the NIH will not accept similar grant applications with essentially the same research focus from the same applicant organization. This includes derivative or multiple applications that propose to develop a single product, process or service that, with non substantive modifications, can be applied to a variety of purposes. Applicants may not simultaneously submit identical/essentially identical applications under both this funding opportunity and any other HHS FOA, including the current parent SBIR or STTR FOAs.
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Opportunity Summary:
Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (SBIR R43/R44), Funding Opportunity Number PA-06-375, is a National Institutes of Health (NIH) grant opportunity aimed at small businesses that can build new research tools for studying brain-localized G protein coupled receptors (GPCRs) in the context of mental health. The core purpose is technology development: the program wants companies to create technologies, platforms, or innovative ways of applying existing technologies that make it easier for researchers to understand GPCR structure and/or function in the brain, and potentially to discover or characterize highly selective agonists and antagonists for specific GPCR subtypes. The emphasis is on receptors relevant to mental health function or dysfunction, and the National Institute of Mental Health (NIMH) signals interest in projects targeting both well-characterized receptor subtypes and orphan GPCRs (receptors whose endogenous ligands or roles may not yet be fully known). In practical terms, this means the FOA is trying to expand the toolbox available to neuroscience and psychiatric research by enabling better receptor biology, better measurement, and better pharmacologic probing of GPCRs that matter for brain disorders.
This FOA uses the Small Business Innovation Research (SBIR) mechanisms R43/R44 and supports Phase I, Phase II, and Fast Track applications. Phase I is intended to establish feasibility and the scientific or technical merit of a proposed innovation, while Phase II supports more advanced development, refinement, and steps that move the technology closer to broader research use or commercialization. The FOA allows Phase I budgets of up to $250,000 in total costs per year for up to two years, and Phase II budgets of up to $450,000 in total costs per year for up to three years. The announcement also makes clear that there is no set-aside funding pool specifically reserved for this program and that the number of awards and total dollars committed were not predetermined, so funding decisions would depend on application quality, program priorities, and available funds in the relevant award cycles.
Eligibility is limited to United States small business concerns (SBCs); foreign institutions are not eligible to apply. The Project Director/Principal Investigator has an SBIR-specific requirement: their primary employment (more than 50 percent) must be with the small business at the time of award and throughout the project period. The FOA states that any individual with the skills, knowledge, and resources necessary to carry out the research can serve in that role, and it reiterates NIH’s standard encouragement for participation by individuals from underrepresented racial and ethnic groups and individuals with disabilities. The program also permits a small business to submit multiple applications as long as each is scientifically distinct. At the same time, NIH will not accept multiple submissions from the same organization that are essentially the same project with only minor changes, or a set of closely related submissions that amount to developing one core product and rebranding it for different uses without substantive differences. Applicants also may not submit identical or essentially identical applications to multiple HHS funding opportunities at the same time, including the parent SBIR or STTR announcements.
Administratively, this opportunity is categorized as a discretionary grant in the health area and is associated with CFDA 93.242 (Mental Health Research Grants). It does not require cost sharing or matching. The FOA was originally posted April 28, 2006, with multiple receipt dates, and it later carried a current closing date listed as January 7, 2010, with an archive date of February 7, 2010, reflecting that it is an archived announcement rather than a currently open solicitation. It also runs in parallel with an STTR companion FOA of identical scientific scope (PA-06-374), which uses the R41/R42 mechanisms and is meant for projects that formally involve a nonprofit research institution partner under STTR rules. For applicants deciding between the two, the scientific goals are the same, but the business structure and effort requirements differ between SBIR and STTR.
Overall, PA-06-375 is best understood as an NIH/NIMH push to accelerate innovation around brain GPCR research by funding small businesses to produce enabling tools and methods. Rather than funding basic hypothesis-driven studies alone, it prioritizes practical technology advances that help the broader field interrogate receptor structure and signaling, map receptor function in brain systems relevant to psychiatric conditions, and improve the ability to find or validate highly selective compounds for specific GPCR targets, including less-explored orphan receptors.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Novel Tools for Investigating Brain derived GPCRs in Mental Health Research (SBIR R43/R44).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-06-375.
Which federal agency offers this opportunity?
This is a National Institutes of Health (NIH) funding opportunity, with interests highlighted by the National Institute of Mental Health (NIMH).
What is the main purpose of PA-06-375?
The core purpose is technology development. The program aims to support small businesses in creating new research tools, technologies, platforms, or innovative applications of existing technologies that make it easier to study brain-localized G protein coupled receptors (GPCRs) in the context of mental health research.
What kinds of technologies or tools is this FOA looking for?
The FOA emphasizes tools that enable better understanding of GPCR structure and/or function in the brain, and tools that could support discovery or characterization of highly selective agonists and antagonists for specific GPCR subtypes. The emphasis is on practical, enabling methods that expand the research toolbox available to neuroscience and psychiatric research.
What scientific area does the FOA focus on?
It focuses on brain-derived (brain-localized) GPCRs and their relevance to mental health function or dysfunction, including receptors implicated in brain disorders.
Does the FOA include interest in orphan GPCRs?
Yes. NIMH signals interest in projects that target both well-characterized receptor subtypes and orphan GPCRs (receptors whose endogenous ligands or roles may not yet be fully known).
Is this FOA intended to fund basic hypothesis-driven research?
The emphasis described is on enabling technology advances rather than funding basic hypothesis-driven studies alone. The goal is to develop tools and methods that help the broader field interrogate receptor biology and signaling and improve pharmacologic probing of GPCR targets.
What grant mechanisms are used in this opportunity?
This FOA uses the SBIR mechanisms R43/R44.
What project phases are supported under PA-06-375?
The FOA supports Phase I, Phase II, and Fast Track applications under SBIR.
What is the purpose of Phase I under this FOA?
Phase I is intended to establish the feasibility and the scientific or technical merit of the proposed innovation.
What is the purpose of Phase II under this FOA?
Phase II supports more advanced development and refinement, including steps that move the technology closer to broader research use or commercialization.
What are the Phase I budget limits?
Phase I budgets are allowed up to $250,000 in total costs per year for up to two years.
What are the Phase II budget limits?
Phase II budgets are allowed up to $450,000 in total costs per year for up to three years.
Is there a dedicated set-aside funding pool for this FOA?
No. The FOA states there is no set-aside funding pool specifically reserved for this program.
Are the number of awards and total dollars predetermined?
No. The FOA indicates that the number of awards and total dollars committed were not predetermined. Funding decisions depend on application quality, program priorities, and available funds in relevant cycles.
Who is eligible to apply?
Eligibility is limited to United States small business concerns (SBCs).
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply under this FOA.
What is the SBIR requirement for the Project Director/Principal Investigator (PD/PI)?
The PD/PI must have primary employment with the small business (defined here as more than 50 percent) at the time of award and throughout the project period.
Who can serve as PD/PI under this FOA?
The FOA states that any individual with the skills, knowledge, and resources necessary to carry out the research can serve as PD/PI, as long as the SBIR primary employment requirement is met.
Does the FOA encourage participation by underrepresented groups?
Yes. It reiterates NIH encouragement for participation by individuals from underrepresented racial and ethnic groups and individuals with disabilities.
Can a small business submit more than one application?
Yes. A small business may submit multiple applications as long as each is scientifically distinct.
Are there restrictions on submitting very similar applications?
Yes. NIH will not accept multiple submissions from the same organization that are essentially the same project with only minor changes, or a set of closely related submissions that amount to developing one core product and simply rebranding it for different uses without substantive differences.
Can applicants submit identical applications to multiple HHS opportunities at the same time?
No. Applicants may not submit identical or essentially identical applications to multiple HHS funding opportunities at the same time, including the parent SBIR or STTR announcements.
Does this opportunity require cost sharing or matching funds?
No. The FOA states it does not require cost sharing or matching.
How is this opportunity categorized administratively?
It is categorized as a discretionary grant in the health area.
What CFDA number is associated with this FOA?
This opportunity is associated with CFDA 93.242 (Mental Health Research Grants).
When was this FOA originally posted?
The FOA was originally posted on April 28, 2006, and it referenced multiple receipt dates.
Is PA-06-375 currently open?
No. The information provided indicates a current closing date of January 7, 2010 and an archive date of February 7, 2010, meaning it is an archived announcement rather than a currently open solicitation.
Is there a related STTR opportunity with the same scientific scope?
Yes. The FOA runs in parallel with an STTR companion announcement of identical scientific scope: PA-06-374.
What mechanisms are used for the companion STTR FOA?
The companion STTR FOA uses the R41/R42 mechanisms.
How do SBIR and STTR differ for these companion opportunities?
The scientific goals are described as the same, but the opportunities differ in business structure and effort requirements. The STTR path is meant for projects that formally involve a nonprofit research institution partner under STTR rules.
What is the big-picture goal of this NIH/NIMH effort?
The FOA is positioned as an NIH/NIMH push to accelerate innovation around brain GPCR research by funding small businesses to produce enabling tools and methods that improve the ability to study receptor structure, signaling, and function in brain systems relevant to psychiatric conditions, including the ability to find or validate highly selective compounds for GPCR targets.
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