Opportunity Information: Apply for PA 07 404
Apply for PA 07 404
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Nutrition and Alcohol Related Health Outcomes (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 16, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments County governments Small businesses City or township governments Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Nutrition and Alcohol Related Health Outcomes (R03) opportunity (Funding Opportunity Number PA-07-404) is an NIH discretionary grant program designed to encourage smaller, targeted research projects that clarify how nutrition influences alcohol-related health outcomes. It is sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) in collaboration with the National Cancer Institute (NCI) and the NIH Office of Dietary Supplements (ODS). At its core, the announcement invites research that examines associations between dietary factors and the development, prevention, or treatment of health problems connected to alcohol use, with studies allowed in both human populations and animal models.
The scientific aim is intentionally broad: applicants are encouraged to investigate how nutrition interacts with alcohol exposure to shape outcomes such as alcohol dependence, psychiatric comorbidities, and a wide range of chronic or acute diseases. The FOA also explicitly highlights organ function and organ damage, meaning projects can focus on how nutritional status, specific nutrients, dietary patterns, or supplementation may worsen or mitigate alcohol-related injury in organs such as the liver, pancreas, brain, cardiovascular system, and others. The announcement is structured to stimulate diverse lines of inquiry, recognizing that alcohol-related harms can be driven or modified by metabolic pathways, inflammation, micronutrient deficiencies, dietary behaviors, and interactions between alcohol and nutrients at the cellular and systems levels.
In terms of acceptable approaches, the program is open to multiple study designs and disciplines. Projects may be biomedical and mechanistic (for example, studies that test biological pathways linking nutrient status to alcohol-induced tissue injury), epidemiologic (such as population-based analyses of diet quality and alcohol-related disease risk), or intervention-oriented (including trials or smaller interventions that test whether nutritional changes can improve alcohol-related outcomes). The flexibility is important because the FOA is not limited to one method or disease endpoint; it is oriented toward building a stronger evidence base across prevention, disease progression, and treatment-relevant questions.
The funding mechanism is the NIH Small Research Grant (R03), which is typically used for limited-scope projects that can be completed with modest resources. The FOA notes several kinds of work that fit the R03 format, including pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and efforts focused on developing research methods or new research technologies. In practice, that means the program can support early-stage studies that generate preliminary data for larger grants, analyses that leverage existing cohorts or biobanks to answer nutrition-alcohol questions efficiently, and focused methodological work that improves how researchers measure diet, nutrient biomarkers, alcohol exposure, or related outcomes.
This R03 announcement runs in parallel with two other NIH opportunities that cover the same scientific scope but use different grant mechanisms: PA-07-403 (R01) and PA-07-405 (R21). The parallel structure signals that NIH is trying to build a pipeline of research in this area, from exploratory or proof-of-concept efforts (R03 and R21) to larger, more comprehensive studies (R01), all centered on the intersection of nutrition and alcohol-related health.
Eligibility is broad and includes many types of U.S. domestic organizations, such as state and local governments, tribal governments and tribal organizations, public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations, and small businesses. The announcement also states that foreign institutions are eligible to apply, that eligible federal agencies may apply, and that faith-based or community-based organizations are eligible as well. There is no cost sharing or matching requirement, which reduces barriers for applicants that might not have funds to contribute to the project budget.
Administratively, the opportunity is categorized under CFDA numbers 93.273 (Alcohol Research Programs) and 93.393 (Cancer Cause and Prevention Research), reflecting the involvement of NIAAA and NCI and the relevance of nutrition and alcohol to cancer risk and prevention. The FOA was posted July 16, 2007, and it used multiple receipt dates rather than a single deadline, meaning applications could be submitted on recurring standard NIH due dates during the active period of the announcement. The full text of the announcement was hosted on the NIH Grants Guide website at the link provided in the source data.
FAQs: Nutrition and Alcohol Related Health Outcomes (R03) - PA-07-404
What is the Nutrition and Alcohol Related Health Outcomes (R03) opportunity?
It is an NIH discretionary grant opportunity (Funding Opportunity Number PA-07-404) that supports smaller, targeted research projects focused on how nutrition influences alcohol-related health outcomes.
Which NIH organizations sponsor or collaborate on this FOA?
The opportunity is sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in collaboration with the National Cancer Institute (NCI) and the NIH Office of Dietary Supplements (ODS).
What is the main purpose of the program?
The program encourages research that clarifies how dietary factors and nutritional status relate to the development, prevention, or treatment of health problems connected to alcohol use.
What kinds of research questions does the FOA encourage?
The scientific scope is intentionally broad. Projects can examine how nutrition interacts with alcohol exposure to influence outcomes such as alcohol dependence, psychiatric comorbidities, and a range of chronic or acute diseases.
Does the FOA support research on organ function and organ damage?
Yes. The FOA explicitly highlights organ function and organ damage, including work on how nutrition may worsen or mitigate alcohol-related injury in organs such as the liver, pancreas, brain, cardiovascular system, and others.
Are both human and animal studies allowed?
Yes. The announcement allows studies in both human populations and animal models.
What types of dietary or nutrition exposures can be studied?
Projects may focus on nutritional status, specific nutrients, dietary patterns, supplementation, micronutrient deficiencies, dietary behaviors, and interactions between alcohol and nutrients at cellular and systems levels.
What types of study designs are acceptable?
The FOA is open to multiple study designs and disciplines, including biomedical and mechanistic studies, epidemiologic studies, and intervention-oriented projects such as trials or smaller interventions.
Is the program limited to one disease endpoint or a single research method?
No. The FOA is not limited to one method or disease endpoint and is oriented toward building evidence across prevention, disease progression, and treatment-relevant questions.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH Small Research Grant (R03) mechanism, which is typically used for limited-scope projects that can be completed with modest resources.
What kinds of projects fit the R03 format under this announcement?
The FOA notes that appropriate R03 projects can include pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and efforts focused on developing research methods or new research technologies.
Can the grant support secondary analyses of existing datasets or cohorts?
Yes. Secondary analyses of existing datasets are explicitly listed as a type of work that fits the R03 format.
Can the grant support method development related to measuring diet or alcohol exposure?
Yes. The announcement includes developing research methods or new research technologies, including work that improves measurement of diet, nutrient biomarkers, alcohol exposure, or related outcomes.
How does PA-07-404 relate to other NIH opportunities in the same scientific area?
This R03 announcement runs in parallel with PA-07-403 (R01) and PA-07-405 (R21), which cover the same scientific scope but use different NIH grant mechanisms.
What is the difference between the parallel FOAs mentioned (R01, R21, R03)?
Based on the information provided, they share the same scientific scope but differ by mechanism: R03 supports smaller, limited-scope projects, while R21 and R01 represent other NIH mechanisms intended to support work along a pipeline from exploratory efforts to larger, comprehensive studies.
Who is eligible to apply?
Eligibility is broad. It includes many types of U.S. domestic organizations such as state and local governments, tribal governments and tribal organizations, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations, and small businesses.
Are foreign institutions eligible to apply?
Yes. The announcement states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The announcement states that faith-based or community-based organizations are eligible.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What CFDA numbers are associated with this opportunity?
The opportunity is categorized under CFDA 93.273 (Alcohol Research Programs) and 93.393 (Cancer Cause and Prevention Research).
When was this FOA posted?
The FOA was posted on July 16, 2007.
Does this opportunity have a single deadline or multiple receipt dates?
It used multiple receipt dates rather than a single deadline, meaning applications could be submitted on recurring standard NIH due dates during the active period of the announcement.
Where was the full text of the announcement hosted?
The full text was hosted on the NIH Grants Guide website at the link provided in the source data.
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