Opportunity Information: Apply for PA 11 165
Apply for PA 11 165
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Mar 17, 2011 and posted on Mar 17, 2011.
- Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Public housing authorities/Indian housing authorities County governments City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R01) opportunity (Funding Opportunity Number PA 11-165) was a National Institutes of Health (NIH) discretionary grant program designed to stimulate investigator-initiated research on how nutrition and dietary factors influence cardiomyopathies and heart failure. It was issued jointly by the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS). The central purpose was to strengthen the evidence base needed to guide practical, rational nutritional approaches for people who already have heart failure (across different stages and clinical presentations) and to support preventive strategies for individuals at elevated risk.
The FOA specifically encouraged research that tackles the role of diet and nutrition in three broad areas: causation (how dietary exposures contribute to disease development), prevention (how nutrition can reduce risk or delay onset), and management or treatment (how dietary patterns, nutrients, or supplementation strategies might improve outcomes in established disease). The emphasis was not limited to one research style; instead, the announcement signaled interest in mechanistic work (studies that explain biological pathways and causal mechanisms), translational studies (moving insights from basic science toward clinical relevance), and applied interdisciplinary research (work that integrates multiple fields such as cardiology, nutrition science, metabolism, aging biology, epidemiology, behavioral science, and implementation-oriented approaches). Projects could be conducted in humans or animal models, as long as the designs were scientifically rigorous and centered on clear hypothesis testing rather than purely descriptive exploration.
A key theme in the announcement was building a “satisfactory science base” for nutritional management in heart failure. In practical terms, this means generating stronger evidence that could eventually inform clinical guidance about diet quality, dietary patterns, nutrient adequacy, and the thoughtful use of dietary supplements in heart failure care. Because heart failure is heterogeneous and often coexists with other conditions (including age-related changes, frailty, kidney disease, diabetes, and obesity), the program’s involvement of NHLBI and NIA underscored interest in work relevant to cardiovascular disease broadly and to aging-related physiology and clinical complexity. ODS participation highlighted a particular interest in dietary supplements and nutrient-related questions where the evidence was incomplete or inconsistent, especially when supplement use is common but definitive guidance is lacking.
The award mechanism was the NIH R01, which is the standard investigator-initiated research project grant and typically supports a defined line of research with a robust, testable research plan. The activity categories aligned with health research, and the opportunity was listed under CFDA 93.837 (Cardiovascular Diseases Research) and 93.866 (Aging Research). There was no cost sharing or matching requirement, meaning applicants were not expected to provide a non-federal match as a condition of funding.
Eligibility was intentionally broad and included many types of organizations that might conduct biomedical and behavioral research. Eligible applicants included state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; public and private institutions of higher education; nonprofits both with and without 501(c)(3) status (other than higher education institutions); for-profit organizations (including small businesses and other for-profit entities); independent school districts; Native American tribal organizations and tribal governments (including federally recognized tribes); and a wide array of other institutions described in NIH eligibility language. The eligibility notes explicitly referenced inclusion of Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). The announcement also allowed foreign (non-U.S.) components of U.S. organizations, signaling openness to international collaboration when scientifically justified.
From an administrative standpoint, this opportunity was posted and created on March 17, 2011, with an original and current closing date of May 7, 2014, and it was archived on June 7, 2014. The official announcement was hosted on the NIH grants website, and NIH’s Office of Extramural Research (OER) provided webmaster contact emails for access or linking issues. Although the FOA is archived and no longer active, its scope provides a clear picture of the kinds of nutrition-focused heart failure research NIH sought to advance during that period: interdisciplinary, hypothesis-driven studies in humans and animals aimed at clarifying how dietary exposures and interventions can prevent heart failure, slow progression, or improve clinical management and patient outcomes.
FAQs: Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R01) (PA-11-165)
What is the "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R01)" opportunity?
This was a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PA 11-165) that used the R01 mechanism to support investigator-initiated research on how nutrition and dietary factors influence cardiomyopathies and heart failure.
Which NIH organizations issued this funding opportunity?
The opportunity was issued jointly by the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS).
What was the main purpose of PA 11-165?
The central purpose was to strengthen the evidence base needed to guide practical, rational nutritional approaches for people who already have heart failure (across different stages and clinical presentations) and to support preventive strategies for individuals at elevated risk.
What research areas did the FOA encourage?
The FOA encouraged research addressing nutrition and diet in three broad areas: causation (dietary exposures contributing to disease development), prevention (nutrition reducing risk or delaying onset), and management/treatment (dietary patterns, nutrients, or supplementation strategies improving outcomes in established disease).
What types of study approaches were of interest under this opportunity?
The announcement signaled interest in mechanistic studies (biological pathways and causal mechanisms), translational studies (moving basic insights toward clinical relevance), and applied interdisciplinary research integrating fields such as cardiology, nutrition science, metabolism, aging biology, epidemiology, behavioral science, and implementation-oriented approaches.
Were both human and animal studies allowed?
Yes. Projects could be conducted in humans or in animal models, as long as study designs were scientifically rigorous and centered on clear hypothesis testing rather than purely descriptive exploration.
What does "building a satisfactory science base" for nutritional management in heart failure mean in this FOA?
In practical terms, it referred to generating stronger evidence that could eventually inform clinical guidance about diet quality, dietary patterns, nutrient adequacy, and the thoughtful use of dietary supplements in heart failure care.
Why did this FOA emphasize heart failure heterogeneity and coexisting conditions?
The FOA highlighted that heart failure is heterogeneous and often coexists with other conditions (including age-related changes, frailty, kidney disease, diabetes, and obesity), which creates a need for nutrition research relevant to varied clinical presentations and complex patient populations.
How did NIA's involvement shape the scientific focus?
NIA participation underscored interest in work relevant to aging-related physiology and clinical complexity, given the overlap between aging, frailty, comorbidity patterns, and heart failure outcomes.
How did ODS involvement shape the scientific focus?
ODS participation highlighted interest in dietary supplements and nutrient-related questions where evidence was incomplete or inconsistent, particularly in areas where supplement use is common but definitive guidance is lacking.
What award mechanism did this funding opportunity use?
The award mechanism was the NIH R01, a standard investigator-initiated research project grant that typically supports a defined line of research with a robust, testable research plan.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement, meaning applicants were not expected to provide a non-federal match as a condition of funding.
What CFDA program areas were associated with this FOA?
The opportunity was listed under CFDA 93.837 (Cardiovascular Diseases Research) and 93.866 (Aging Research).
Who was eligible to apply?
Eligibility was broad and included many types of organizations that might conduct biomedical and behavioral research, including various levels of government, higher education institutions, nonprofits (with and without 501(c)(3) status), for-profit organizations, independent school districts, tribal organizations and governments, and other institutions described in NIH eligibility language.
Were tribal organizations and tribal governments eligible?
Yes. Native American tribal organizations and tribal governments (including federally recognized tribes) were included as eligible applicants.
Were minority-serving institutions referenced as eligible applicants?
Yes. The eligibility notes explicitly referenced Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based and community-based organizations eligible?
Yes. The eligibility notes explicitly referenced faith-based and community-based organizations.
Could for-profit organizations apply?
Yes. For-profit organizations (including small businesses and other for-profit entities) were listed as eligible applicants.
Could non-U.S. (foreign) organizations apply?
Yes. The eligibility notes referenced non-U.S. entities (foreign organizations) as eligible applicants.
Were foreign components of U.S. organizations allowed?
Yes. The announcement allowed foreign (non-U.S.) components of U.S. organizations, indicating openness to international collaboration when scientifically justified.
When was PA 11-165 posted and created?
It was posted and created on March 17, 2011.
What were the closing dates for this opportunity?
The original closing date and the current closing date were both May 7, 2014.
Is this funding opportunity still active?
No. The FOA is archived and is no longer active. It was archived on June 7, 2014.
Where was the official announcement hosted?
The official announcement was hosted on the NIH grants website.
Who provided contact information for access or linking issues related to the posting?
NIH's Office of Extramural Research (OER) provided webmaster contact emails for access or linking issues.
What kind of research emphasis did NIH signal for this program during its active period?
The scope described a clear interest in interdisciplinary, hypothesis-driven studies in humans and animals aimed at clarifying how dietary exposures and interventions can prevent heart failure, slow progression, or improve clinical management and patient outcomes.
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