Opportunity Information: Apply for PA 11 166
Apply for PA 11 166
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Mar 17, 2011 and posted on Mar 17, 2011.
- Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21) is a National Institutes of Health (NIH) grant opportunity, issued jointly by the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS). It uses the R21 mechanism, which is meant for exploratory or developmental projects that may be early-stage, high-risk/high-reward, or aimed at generating preliminary data that can support a larger follow-on study. The central focus is on how nutrition and dietary factors contribute to the development of cardiomyopathies and heart failure, and how diet-based strategies might help prevent these conditions or improve management once heart failure is present.
The scientific scope is intentionally broad but clearly anchored in heart failure and cardiomyopathy outcomes. The FOA invites mechanistic studies that explain biological pathways linking nutrients, dietary patterns, supplements, or metabolic states to cardiac structure and function. It also welcomes translational work that bridges basic findings into clinically meaningful hypotheses or interventions, along with applied interdisciplinary research that could inform real-world dietary guidance for patients or high-risk groups. Both human and animal studies are considered responsive, which opens the door to projects ranging from controlled feeding or biomarker studies in people to preclinical work testing dietary manipulations, nutrient deficiencies, or supplement exposures in relevant disease models.
A key theme is building a stronger evidence base for rational nutritional management across the spectrum of heart failure, including different stages or phenotypes, and for prevention strategies in individuals at elevated risk. In practical terms, the funding opportunity is trying to move the field beyond general dietary advice and toward more specific, evidence-driven recommendations that reflect disease stage, patient characteristics, and plausible mechanisms. Because NIA is involved, projects that intersect with aging, older adult populations, age-related physiological changes, frailty, sarcopenia, or age-specific dietary needs may be particularly relevant, as long as they are clearly tied to heart failure causation, prevention, or management.
Administratively, this is a discretionary grant opportunity under Funding Opportunity Number PA-11-166, titled exactly as listed above. It falls under the NIH health funding activity category and is associated with CFDA numbers 93.837 (Cardiovascular Diseases Research) and 93.866 (Aging Research). There is no cost sharing or matching requirement. The opportunity was posted and created on March 17, 2011, with a closing date of May 7, 2014, and an archive date of June 7, 2014, indicating that this particular announcement is no longer active but remains relevant as a reference point for the type of work NIH sought to stimulate in this area.
The budget cap listed for awards is an application ceiling of $200,000, consistent with the typical intent of the R21 program to support smaller, time-limited exploratory projects rather than large multi-year clinical trials. The eligible applicant pool is wide and includes public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations other than small businesses, small businesses, and a variety of government entities (state, county, city/township, special districts). It also explicitly includes Tribal governments and Tribal organizations, public/Indian housing authorities, independent school districts, and a range of mission-driven institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Notably, foreign (non-U.S.) organizations are allowed, and foreign components of U.S. organizations are permitted, which signals an openness to international expertise and study settings when scientifically justified.
For applicants or readers looking for full details, NIH provided an official link to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PA-11-166.html. For technical issues accessing the announcement or linking to it, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21)
What is the name of this grant opportunity?
The opportunity is titled Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-11-166.
Which federal agency offers this opportunity?
This is a National Institutes of Health (NIH) grant opportunity.
Which NIH organizations issued this FOA jointly?
The FOA was issued jointly by the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS).
What grant mechanism does it use?
It uses the R21 mechanism, intended for exploratory or developmental research.
What kinds of projects is an R21 meant to support in this context?
Based on the description, the R21 is positioned for projects that are early-stage, potentially high-risk/high-reward, and/or designed to generate preliminary data that could support a larger follow-on study.
What is the central scientific focus of the FOA?
The central focus is understanding how nutrition and dietary factors contribute to the development of cardiomyopathies and heart failure, and how diet-based strategies might help prevent these conditions or improve management once heart failure is present.
Is the scientific scope narrow or broad?
The scope is described as intentionally broad, but it is clearly anchored in outcomes related to heart failure and cardiomyopathy.
What types of research does the FOA explicitly invite?
The FOA invites:
- Mechanistic studies explaining biological pathways linking nutrients, dietary patterns, supplements, or metabolic states to cardiac structure and function
- Translational work that bridges basic findings into clinically meaningful hypotheses or interventions
- Applied interdisciplinary research that could inform real-world dietary guidance for patients or high-risk groups
Are both human and animal studies allowed?
Yes. The FOA indicates that both human and animal studies are considered responsive.
What are examples of study approaches mentioned as fitting within the scope?
Examples described include controlled feeding or biomarker studies in people, and preclinical studies testing dietary manipulations, nutrient deficiencies, or supplement exposures in relevant disease models.
Does the FOA emphasize prevention, management, or both?
Both. It emphasizes prevention strategies for individuals at elevated risk and improved management strategies across the spectrum of heart failure once present.
Does the FOA address different stages or phenotypes of heart failure?
Yes. A stated theme is improving the evidence base for nutritional management across different stages or phenotypes of heart failure.
What is the overall goal related to dietary recommendations?
The opportunity aims to move beyond general dietary advice toward more specific, evidence-driven recommendations that reflect disease stage, patient characteristics, and plausible mechanisms.
How does the involvement of the National Institute on Aging (NIA) affect relevance?
Because NIA is involved, projects intersecting with aging and older adult populations may be particularly relevant when they are clearly tied to heart failure causation, prevention, or management. The FOA specifically notes areas such as age-related physiological changes, frailty, sarcopenia, and age-specific dietary needs.
What is the funding activity category?
It falls under the NIH health funding activity category.
What CFDA numbers are associated with this FOA?
The FOA is associated with CFDA numbers 93.837 (Cardiovascular Diseases Research) and 93.866 (Aging Research).
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the budget cap or application ceiling listed?
The listed award budget cap is an application ceiling of $200,000, consistent with the R21 program intent to support smaller, time-limited exploratory projects.
Is this FOA currently active?
No. It was posted and created on March 17, 2011, had a closing date of May 7, 2014, and an archive date of June 7, 2014, indicating it is no longer active and remains as a reference point.
When was the opportunity posted and created?
It was posted and created on March 17, 2011.
What was the closing date?
The closing date was May 7, 2014.
What does the archive date mean here?
The archive date listed is June 7, 2014, which signals that this specific announcement has been archived and is not active for new submissions under that FOA.
Who is eligible to apply?
The eligible applicant pool is described as wide and includes:
- Public and private institutions of higher education
- Nonprofits (including 501(c)(3) and certain non-501(c)(3) entities)
- For-profit organizations (other than small businesses)
- Small businesses
- Government entities (state, county, city/township, special districts)
- Tribal governments and Tribal organizations
- Public/Indian housing authorities
- Independent school districts
- Mission-driven institutions including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs)
Are foreign (non-U.S.) organizations allowed to apply?
Yes. The FOA explicitly states that foreign (non-U.S.) organizations are allowed.
Are foreign components of U.S. organizations permitted?
Yes. The FOA states that foreign components of U.S. organizations are permitted, indicating that international expertise or study settings can be included when scientifically justified.
Where can applicants find the official full announcement?
The official NIH link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-11-166.html
Who should be contacted for technical issues accessing or linking to the announcement?
The contact listed for technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Is this described as a discretionary grant opportunity?
Yes. It is described as a discretionary grant opportunity.
Does the FOA suggest the type of studies it is not primarily designed to fund?
Yes, by implication. The description notes that the R21 is intended for smaller, exploratory projects rather than large multi-year clinical trials.
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Previous opportunity: Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R01)
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