Opportunity Information: Apply for PA 16 087
Apply for PA 16 087
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Oocyte Mitochondrial Function in Relation to Fertility, Aging, and Mitochondrial Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Jan 25, 2016 and posted on Jan 25, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Oocyte Mitochondrial Function in Relation to Fertility, Aging, and Mitochondrial Diseases (R21)" (Funding Opportunity Number PA-16-087) is a discretionary NIH research grant focused on understanding how mitochondria in human and animal oocytes influence fertility outcomes, reproductive aging, and the risk of transmitting mitochondrial diseases to offspring. The central idea is that mitochondria are not just power sources for the egg cell; they also shape egg quality, developmental competence after fertilization, and potentially the long-term health of the resulting child. By supporting exploratory, high-impact work, the program aims to push the field toward clearer biological insight and toward practical strategies that could improve reproductive outcomes for women affected by mitochondrial dysfunction.
The scientific emphasis is on gaining fundamental insight into what mitochondria do in the oocyte, what happens when those functions break down, and how those problems may persist or echo across later developmental stages. This includes the long-term consequences of mitochondrial dysfunction that begins in the oocyte, such as impaired fertilization, poor embryo development, age-related declines in egg quality, and the possibility of passing mitochondrial defects to the next generation. The FOA also signals strong interest in research that does more than describe problems, encouraging projects that point toward solutions, such as therapeutic interventions or alternative approaches designed to restore or compensate for mitochondrial dysfunction in the oocyte.
A major practical goal of the program is translational in spirit, even though it is framed as fundamental and exploratory research: results are expected to lay groundwork for approaches that could help women experiencing infertility or subfertility linked to mitochondrial issues. The announcement also explicitly connects mitochondrial dysfunction in oocytes to broader health concerns, reflecting an interest in the well-being of offspring, not only pregnancy rates or short-term reproductive endpoints. In other words, the research is meant to inform both fertility improvement and healthier developmental trajectories, with attention to how early mitochondrial quality might influence later outcomes.
This is an R21 mechanism, which typically supports innovative, early-stage, and potentially higher-risk projects where preliminary data may be limited but the potential payoff is large. Consistent with that purpose, the FOA highlights "innovative and high-risk/impact studies" and encourages work that could produce breakthroughs in understanding mitochondrial biology in oocytes or lead to genuinely new tools and capabilities. Examples of the kinds of advances the announcement is trying to stimulate include novel techniques, agents, methodologies, experimental models, or applications that could significantly change how mitochondrial dysfunction is studied, detected, or addressed in reproductive biology and medicine.
In administrative terms, the opportunity was posted January 25, 2016 by HHS-NIH (AgencyName: HHS-NIH11) under CFDA numbers 93.865 and includes a stated award ceiling of $200,000. The original and current closing date listed is May 7, 2019. Eligibility is broad and spans multiple sectors, including state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both with and without 501(c)(3) status); for-profit organizations (excluding small businesses as a separate category, but also including small businesses); independent school districts; and other applicants as described in NIH eligibility language. Overall, the FOA is aimed at mobilizing a wide scientific community to tackle a focused but high-impact problem: how oocyte mitochondria affect fertility, reproductive aging, and mitochondrial disease risk, and how that knowledge can be turned into real improvements for patients and future children.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Oocyte Mitochondrial Function in Relation to Fertility, Aging, and Mitochondrial Diseases (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-16-087.
Which agency is offering this grant?
This is an NIH grant opportunity from HHS-NIH (AgencyName: HHS-NIH11).
What type of grant mechanism is this?
This opportunity uses the NIH R21 mechanism, which typically supports exploratory, innovative projects that may be higher-risk/high-impact and may have limited preliminary data.
What is the main scientific focus of the opportunity?
The focus is on understanding how mitochondria in human and animal oocytes influence fertility outcomes, reproductive aging, and the risk of transmitting mitochondrial diseases to offspring.
Why are mitochondria in oocytes important in this program?
The program emphasizes that oocyte mitochondria are not only energy sources. They are also tied to egg quality, developmental competence after fertilization, and potentially long-term health outcomes for the resulting child.
What kinds of research questions does the program prioritize?
Projects are expected to generate fundamental insight into what mitochondria do in the oocyte, what happens when those functions break down, and how mitochondrial dysfunction originating in the oocyte may affect later developmental stages.
What fertility or developmental problems are highlighted as being linked to mitochondrial dysfunction in oocytes?
The opportunity highlights impaired fertilization, poor embryo development, age-related declines in egg quality, and the possibility of passing mitochondrial defects to the next generation.
Is the program interested only in describing mitochondrial problems, or also in solutions?
The FOA signals strong interest in work that goes beyond describing problems and points toward solutions, including therapeutic interventions or alternative approaches intended to restore or compensate for mitochondrial dysfunction in the oocyte.
Is this opportunity considered translational or basic research?
It is framed as fundamental and exploratory, but it is translational in spirit. The intent is that results will lay groundwork for approaches that could help women experiencing infertility or subfertility linked to mitochondrial issues.
Does the opportunity consider health outcomes beyond pregnancy rates?
Yes. The announcement explicitly connects oocyte mitochondrial dysfunction to broader concerns about offspring well-being, not just short-term reproductive endpoints.
What types of advances does the FOA encourage?
It encourages innovative, high-risk/high-impact studies that could lead to breakthroughs in understanding mitochondrial biology in oocytes or create genuinely new tools and capabilities. Examples mentioned include novel techniques, agents, methodologies, experimental models, or applications that change how mitochondrial dysfunction is studied, detected, or addressed in reproductive biology and medicine.
Are both human and animal studies within scope?
Yes. The opportunity references mitochondria in human and animal oocytes.
When was the opportunity posted?
The opportunity was posted on January 25, 2016.
What is the application closing date?
The listed original and current closing date is May 7, 2019.
What is the stated award ceiling?
The stated award ceiling is $200,000.
What CFDA number(s) are associated with this opportunity?
The opportunity lists CFDA 93.865.
Who is eligible to apply?
Eligibility is broad and includes state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses); independent school districts; and other applicants as described in NIH eligibility language.
Are for-profit organizations allowed to apply?
Yes. For-profit organizations are included in the eligibility list, and small businesses are also included.
Are nonprofit organizations without 501(c)(3) status eligible?
Yes. The eligibility list includes nonprofit organizations with and without 501(c)(3) status.
Can tribal entities apply?
Yes. Federally recognized tribal governments and other tribal organizations are included.
Can government entities apply?
Yes. State, county, and local governments are included.
Can educational organizations apply?
Yes. Public and private institutions of higher education and independent school districts are included.
What is the overarching goal of the program?
The overarching goal is to mobilize a wide scientific community to understand how oocyte mitochondria affect fertility, reproductive aging, and mitochondrial disease risk, and to help turn that knowledge into real improvements for patients and future children.
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