Opportunity Information: Apply for PA 07 056
Apply for PA 07 056
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pancreatic Development and Regeneration Toward Cellular Therapies for Diabetes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 21, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments City or township governments Special district governments Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Independent school districts For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Pancreatic Development and Regeneration Toward Cellular Therapies for Diabetes (R01) opportunity (Funding Opportunity Number PA-07-056) is an NIH grant announcement from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on advancing new cellular approaches to treat diabetes. The central idea is to deepen understanding of how pancreatic beta cells are naturally formed during development and how they might be restored or replaced in adults, then use that knowledge to move toward practical strategies for making functional insulin-producing cells for therapy. The FOA is designed to pull together progress from developmental biology, stem cell biology, and diabetes research to push the field toward cell replacement and regenerative treatments, while also encouraging more investigator-initiated projects, bringing new investigators into the area, and promoting interdisciplinary teams and methods.
Scientifically, the announcement highlights three main research directions. First, it calls for studies of pancreatic development to clarify how endogenous beta cells are generated, with an explicit long-term goal of using developmental principles to create pancreatic islets in culture. Second, it encourages research on the use of stem and progenitor cells as potential starting material to produce pancreatic islets, including both animal and human sources; if human embryonic stem cells are used, investigators are restricted to NIH-approved human embryonic stem cell lines. Third, it supports work on the basic mechanisms that drive beta cell regeneration in the adult pancreas, aiming to identify pathways and processes that could be harnessed to stimulate regeneration or guide the production of new beta cells as the foundation for future cellular therapies for diabetes.
In terms of funding structure, applications are submitted under the NIH Research Project Grant (R01) mechanism. The FOA does not specify a fixed budget cap or project period because it anticipates wide variation in proposed approaches, scale, and experimental scope; as a result, award size and duration are expected to vary by project. Likewise, the number of awards and total dollars are not pre-set and will depend on factors such as the quantity of applications received, their scientific quality, their proposed timelines, and their requested costs. Cost sharing or matching is not required.
Eligibility is broad and includes many categories of domestic applicants such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than higher education institutions), state and local governments (including counties, cities/townships, and special district governments), independent school districts, public and Indian housing authorities, Native American tribal governments and tribal organizations, small businesses, and other for-profit organizations that are not small businesses. The announcement also states that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply.
Administratively, this is a discretionary grant opportunity in the health funding activity category and is associated with CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The opportunity was posted on November 21, 2006, and indicates multiple receipt dates rather than a single deadline, with applicants directed to the full announcement for the specific schedule. The full details are provided through the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-07-056.html). For access or technical issues with the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Pancreatic Development and Regeneration Toward Cellular Therapies for Diabetes (R01).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-07-056.
Which agency and NIH institute are sponsoring this FOA?
This is an NIH grant announcement sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the overall purpose of this FOA?
The FOA focuses on advancing new cellular approaches to treat diabetes by deepening understanding of how pancreatic beta cells are formed during development and how they might be restored or replaced in adults, then using that knowledge to move toward practical strategies for producing functional insulin-producing cells for therapy.
What grant mechanism is used for applications?
Applications are submitted under the NIH Research Project Grant (R01) mechanism.
What kinds of scientific approaches does the FOA aim to bring together?
The FOA is designed to pull together progress across developmental biology, stem cell biology, and diabetes research to accelerate cell replacement and regenerative treatment strategies.
Does the FOA encourage interdisciplinary teams?
Yes. The announcement specifically promotes interdisciplinary teams and methods and aims to bring more investigator-initiated projects into the area.
Does the FOA aim to attract new investigators?
Yes. The FOA explicitly encourages bringing new investigators into this research area.
What are the main research directions highlighted in the FOA?
The announcement highlights three main directions: (1) studies of pancreatic development to clarify how endogenous beta cells are generated, (2) research on stem and progenitor cells as starting material to produce pancreatic islets, and (3) research on mechanisms of beta cell regeneration in the adult pancreas.
What is the long-term goal of the pancreatic development research direction?
A stated long-term goal is to use developmental principles to create pancreatic islets in culture.
Are studies using stem or progenitor cells within scope?
Yes. The FOA encourages research on using stem and progenitor cells as potential starting material to produce pancreatic islets, including both animal and human sources.
Are there restrictions if a project uses human embryonic stem cells?
Yes. If human embryonic stem cells are used, investigators are restricted to NIH-approved human embryonic stem cell lines.
What does the FOA say about beta cell regeneration research in adults?
It supports work on the basic mechanisms that drive beta cell regeneration in the adult pancreas, aiming to identify pathways and processes that could be harnessed to stimulate regeneration or guide production of new beta cells as a foundation for future cellular therapies.
Is there a fixed budget cap for applications?
No. The FOA does not specify a fixed budget cap because it anticipates wide variation in approaches, scale, and experimental scope.
Is there a fixed project period (duration) limit stated in the FOA?
No. The FOA does not specify a single fixed project period; award size and duration are expected to vary by project.
How many awards will be made, and how much total funding is available?
The number of awards and total dollars are not pre-set. They depend on factors such as the number of applications received, scientific quality, proposed timelines, and requested costs.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes many categories of applicants, including domestic public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, other than higher education institutions), state and local governments, independent school districts, public and Indian housing authorities, Native American tribal governments and tribal organizations, small businesses, and other for-profit organizations that are not small businesses.
Are for-profit organizations eligible?
Yes. Both small businesses and other for-profit organizations that are not small businesses are listed as eligible categories.
Are foreign institutions eligible to apply?
Yes. The announcement states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply.
Can faith-based or community-based organizations apply?
Yes. The announcement states that faith-based or community-based organizations may apply.
What is the funding activity category?
This is a discretionary grant opportunity in the health funding activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
When was this opportunity posted?
The opportunity was posted on November 21, 2006.
Is there a single application deadline?
No. The opportunity indicates multiple receipt dates rather than a single deadline, and applicants are directed to the full announcement for the specific schedule.
Where can applicants find the full FOA details?
The full details are provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-07-056.html
Who should be contacted for access or technical issues with the announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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