Research On Adherence To Interventions For Mental Disorders (R01) | Apply Online

Opportunity Summary:

The National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), offered this funding opportunity to support research focused on treatment adherence for mental disorders. The core problem the announcement targets is that even when mental health interventions are proven to work under ideal conditions, their real-world impact can drop sharply when people do not start treatment, do not follow it as intended, or discontinue early. The opportunity emphasizes that adherence challenges exist across medicine in general, but are often more severe in mental health because many psychiatric conditions involve cognitive difficulties, low motivation, impaired insight, and other symptoms that can directly interfere with keeping appointments, taking medications consistently, practicing therapy skills, or maintaining engagement with care. The overall intent is to push the field toward a better understanding of why adherence breaks down and to build practical, evidence-based strategies that improve consistent participation in effective mental health treatments.

In terms of what NIMH wanted researchers to do, the opportunity highlights two major directions. First, it encourages studies that identify and clarify the strongest and most modifiable factors linked to adherence among people with mental disorders. "Modifiable" is an important qualifier here, because the goal is not only to describe predictors of nonadherence, but to find levers that can realistically be changed through clinical practice, service delivery, technology supports, family or peer involvement, or policy and systems approaches. Second, it invites applicants to develop and rigorously test interventions, strategies, or service models designed specifically to increase adherence to treatments that already have demonstrated efficacy. This can include adherence to medications, psychotherapy protocols, combined or stepped-care approaches, and other evidence-based interventions, with the unifying theme being that improving adherence should meaningfully improve outcomes by allowing treatments to work as intended.

The primary funding mechanism for this announcement is the NIH Research Project Grant (R01), which is typically used for mature, well-developed projects with clear aims, a strong design, and sufficient preliminary foundation to support a full-scale research plan. At the same time, the announcement also notes interest in smaller or earlier-stage applications through other NIH mechanisms, specifically the R03 (small research grant) and R21 (exploratory/developmental grant). Those applicants were directed to separate related announcements (PA 06-180 for R03 and PA 06-181 for R21), signaling that NIMH was open to a pipeline of work ranging from pilot testing and method development through larger definitive studies, as long as the focus remained on adherence to mental health interventions.

Funding decisions under this opportunity were contingent on the availability of NIH funds and the receipt of enough high-quality, competitive applications. The announcement does not promise a set number of awards; instead, it makes clear that awards depend on both budget conditions and scientific merit, which is standard for NIH discretionary grant programs.

Administratively, the opportunity is listed as PA 07-076, categorized as a discretionary grant in the health area, and associated with CFDA number 93.242 (Mental Health Research Grants). It did not require cost sharing or matching, meaning applicants were not expected to contribute non-federal funds as a condition of the award. The posting date was November 21, 2006, and it used multiple receipt dates (rather than a single deadline), which typically means applications could be submitted according to recurring NIH submission cycles during the active period of the announcement. The archive date indicates the announcement was later closed (archived June 1, 2009), but the summary remains useful as a description of NIMH priorities and the kinds of adherence research the institute sought to stimulate.

Eligibility was broad and included a wide range of domestic organizations such as state and local governments, federally recognized tribal governments, tribal organizations, public and private institutions of higher education, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits), and for-profit entities (including small businesses and other for-profits). The announcement also explicitly states that foreign institutions were eligible to apply, that eligible federal agencies could apply, and that faith-based and community-based organizations could apply. In practice, this wide eligibility aligns with the real-world nature of adherence research, which often benefits from partnerships across universities, healthcare systems, community providers, social service settings, and other organizations that deliver or support mental health care.

Overall, this opportunity is best understood as NIMH support for research that closes the gap between "treatments that can work" and "treatments that do work in everyday life" by tackling one of the most persistent barriers in mental health care: helping people initiate, participate in, and sustain effective interventions long enough and consistently enough to benefit.

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Health

Next opportunity: Pathophysiology and Treatment Response in Late Life Mood and Anxiety Disorders (R01)

Previous opportunity: Pancreatic Development and Regeneration Toward Cellular Therapies for Diabetes (R01)

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PA 07 076

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PA 07 076) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PA 07 076", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.