Opportunity Information: Apply for PA 07 077
Apply for PA 07 077
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pathophysiology and Treatment Response in Late Life Mood and Anxiety Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 21, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Public and State controlled institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) County governments Small businesses Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Pathophysiology and Treatment Response in Late Life Mood and Anxiety Disorders (R01) opportunity (Funding Opportunity Number PA-07-077) is a National Institutes of Health (NIH) discretionary grant announcement focused on improving what is known about mood and anxiety disorders in older adults. Its central aim is to support research that clarifies the underlying biological and physiological mechanisms (pathophysiology) of late-life depression, anxiety, and related conditions, and then uses those insights in practical ways: to guide the development of new interventions or to predict which older adults are most likely to benefit from existing mental health treatments. A specific emphasis is also placed on drawing new investigators into interdisciplinary research in this area, encouraging teams and approaches that bridge clinical psychiatry, neuroscience, aging research, and related fields.
The primary funding mechanism is the NIH Research Project Grant (R01), which is typically used for well-developed research projects with clear aims, strong preliminary rationale, and rigorous methods. At the same time, the announcement signals interest in receiving applications through additional NIH/NIMH mechanisms suited to different stages and sizes of projects. Smaller or more targeted studies can be proposed through the NIH Small Research Grant (R03), while early-stage or high-risk/high-reward ideas can be routed through the NIH Exploratory/Developmental Research Grant (R21). For projects that are specifically clinical and exploratory in nature, the NIMH Clinical Exploratory Grant Program (R34) is also encouraged. Importantly, the announcement notes that applicants pursuing those alternative mechanisms should submit to the corresponding companion announcements (R03: PA-06-180; R21: PA-06-181; R34: PA-06-248), rather than submitting them as R03/R21/R34 applications under PA-07-077 itself.
In practical terms, the research scope centers on two linked themes: (1) understanding what is different about the biology, brain function, physiology, and broader disease processes that contribute to mood and anxiety disorders in late life, and (2) translating those findings into clinical utility by improving treatment selection, identifying predictors of treatment response, or laying groundwork for new therapeutic strategies tailored to older adults. The logic behind the announcement is that late-life psychiatric conditions often occur alongside age-related changes in the brain and body, as well as medical comorbidity, and that treatment response in older adults can differ from that in younger populations. By supporting studies that connect mechanism to outcome, the program is intended to move beyond symptom description and toward actionable markers and treatment-relevant understanding.
Funding decisions are explicitly contingent on the availability of funds and the receipt of a sufficient number of scientifically strong (meritorious) applications, meaning there is no guaranteed number of awards. The opportunity lists the CFDA number as 93.242 (Mental Health Research Grants) and states that cost sharing or matching is not required, which reduces barriers for many applicants. The posting date is November 21, 2006, and while the announcement historically used multiple receipt dates (rather than a single deadline), the record indicates it was ultimately archived on October 2, 2009.
Eligibility is broad and designed to accommodate many types of research organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, and a wide range of government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal governments and tribal organizations are also included, and the announcement explicitly allows foreign institutions to apply. It also notes that eligible agencies of the federal government may apply, and that faith-based and community-based organizations are eligible as well, reflecting NIH-wide policies on applicant inclusivity.
The administering agency is NIH, and the full announcement was originally hosted through the NIH Grants Guide. For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is typical for older archived announcements where applicants may need help reaching the electronic posting rather than scientific/programmatic guidance.
Frequently Asked Questions (FAQs)
1. What is the funding opportunity and what is its focus?
The opportunity is titled Pathophysiology and Treatment Response in Late Life Mood and Anxiety Disorders (R01), Funding Opportunity Number PA-07-077. It is an NIH discretionary grant announcement focused on improving what is known about mood and anxiety disorders in older adults, especially by clarifying underlying biological and physiological mechanisms and linking those mechanisms to treatment response.
2. What is the central aim of PA-07-077?
The central aim is to support research that (1) clarifies the pathophysiology (biological and physiological mechanisms) of late-life depression, anxiety, and related conditions, and (2) uses those insights in practical ways to guide new interventions or predict which older adults are most likely to benefit from existing treatments.
3. What kinds of research themes does this opportunity emphasize?
The scope centers on two linked themes:
- Mechanisms in late life: Understanding what is different about the biology, brain function, physiology, and broader disease processes contributing to mood and anxiety disorders in older adults.
- Clinical utility and translation: Translating mechanistic findings into clinical usefulness, such as improving treatment selection, identifying predictors of treatment response, or laying groundwork for new therapeutic strategies tailored to older adults.
4. Why is there a special focus on late-life mood and anxiety disorders?
The announcement reflects the idea that psychiatric conditions in late life often occur alongside age-related changes in the brain and body and medical comorbidity, and that treatment response in older adults can differ from response in younger populations. The program encourages studies that connect mechanism to outcome rather than stopping at symptom description.
5. What is meant by “pathophysiology” in this announcement?
Within the context provided, “pathophysiology” refers to the underlying biological and physiological mechanisms that contribute to late-life mood and anxiety disorders, including differences in biology, brain function, and physiological processes that may be especially relevant in older adults.
6. What is the primary NIH funding mechanism for this announcement?
The primary mechanism is the NIH Research Project Grant (R01), typically used for well-developed research projects with clear aims, strong preliminary rationale, and rigorous methods.
7. Are other NIH/NIMH grant mechanisms mentioned, and how should applicants use them?
Yes. The announcement indicates interest in related mechanisms suited to different project types and stages, but it also specifies that those applications should be submitted to their companion announcements, not under PA-07-077 itself. These include:
- R03 (Small Research Grant) via companion announcement PA-06-180
- R21 (Exploratory/Developmental Research Grant) via companion announcement PA-06-181
- R34 (NIMH Clinical Exploratory Grant Program) via companion announcement PA-06-248
8. What types of projects are suggested for R03, R21, and R34 (as referenced in the announcement)?
Based on the descriptions included:
- R03: Smaller or more targeted studies
- R21: Early-stage or high-risk/high-reward ideas
- R34: Projects that are specifically clinical and exploratory in nature
9. Does PA-07-077 encourage interdisciplinary research?
Yes. The opportunity emphasizes bringing new investigators into interdisciplinary research and encourages teams and approaches that bridge clinical psychiatry, neuroscience, aging research, and related fields.
10. Is this announcement trying to attract new investigators?
Yes. A specific emphasis is placed on drawing new investigators into this research area, particularly through interdisciplinary approaches.
11. Are awards guaranteed under this opportunity?
No. Funding decisions are explicitly contingent on availability of funds and the receipt of a sufficient number of scientifically strong (meritorious) applications. The opportunity states there is no guaranteed number of awards.
12. Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
13. What is the CFDA number associated with this opportunity?
The opportunity lists the CFDA number as 93.242 (Mental Health Research Grants).
14. Who is eligible to apply?
Eligibility is broad. Eligible applicants include:
- Public and private institutions of higher education
- Nonprofit organizations (with and without 501(c)(3) status)
- Small businesses
- For-profit organizations other than small businesses
- Government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities)
- Tribal governments and tribal organizations
- Foreign institutions
- Eligible agencies of the federal government
- Faith-based and community-based organizations
15. Are foreign institutions allowed to apply?
Yes. The announcement explicitly allows foreign institutions to apply.
16. Are faith-based and community-based organizations eligible?
Yes. The announcement notes that faith-based and community-based organizations are eligible, consistent with NIH-wide inclusivity policies.
17. Which agency administers this opportunity?
The administering agency is the National Institutes of Health (NIH).
18. Where was the full announcement originally hosted?
The full announcement was originally hosted through the NIH Grants Guide.
19. What are the key dates mentioned for this opportunity?
The posting date is November 21, 2006. The record indicates the announcement was ultimately archived on October 2, 2009. It also notes that it historically used multiple receipt dates rather than a single deadline.
20. Who should be contacted for access or technical issues with the posting?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster: FBOWebmaster@OD.NIH.GOV. This contact is described as typical for older archived announcements where applicants may need help reaching the electronic posting rather than seeking scientific or programmatic guidance.
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