Pathobiology of Emerging Pathogens in Laboratory Animals (R21) | Apply Online

Opportunity Summary:

The Pathobiology of Emerging Pathogens in Laboratory Animals (R21) opportunity (Funding Opportunity Number RFA-RR-10-004) was a National Institutes of Health grant announcement issued by the National Center for Research Resources (NCRR). Its focus was on supporting exploratory, early-stage research that improves understanding of the pathobiology of emerging or potentially emerging infectious agents that affect laboratory animal species. The intent was to generate new knowledge and preliminary data about how these pathogens infect, spread, and cause disease in research animals, because undetected or poorly understood infections can compromise animal welfare, disrupt research outcomes, and create broader biosecurity and public health concerns. The scope explicitly included, but was not limited to, pathogens of aquatic laboratory species, rodents, and non-human primates, reflecting the wide range of animals used in biomedical research and the different infectious risks they face.

The funding mechanism for this announcement was the NIH Exploratory/Developmental Grant (R21), which is typically used for novel, higher-risk ideas where investigators may not yet have extensive preliminary data, but where a short, focused project could open up a new line of research or establish feasibility. This R21 announcement was paired with a parallel funding announcement of the same scientific scope using the R01 mechanism (RFA-RR-10-005), giving applicants a choice between a smaller, exploratory R21 approach or a more extensive R01 project depending on readiness and project scale.

For fiscal year 2011, NIH anticipated up to $750,000 in total direct costs to support up to five R21 awards under this program. The listed award ceiling was $200,000, indicating a relatively modest budget consistent with the R21 goal of supporting early, proof-of-concept work rather than long-term, fully developed research programs. The program did not require cost sharing or matching funds.

Eligibility for applicants was broad and included many types of domestic and non-domestic organizations. Eligible applicants encompassed public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits other than institutions of higher education), for-profit entities (including small businesses and other for-profits), and multiple levels of government (state, county, city or township, special district governments, and certain tribal governments and tribal organizations). The eligibility list also specifically referenced Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions, as well as foreign (non-U.S.) organizations.

Administratively, the opportunity was categorized as a discretionary grant in the health area (CFDA 93.389). It was posted and created on June 22, 2010, with an original and current closing date of August 31, 2010, and it was archived on October 1, 2010. The full announcement was made available through NIH at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-10-004.html). For technical access issues, the contact point was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is standard for problems viewing or linking to the electronic funding announcement.

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