Opportunity Information: Apply for RFA RR 10 005

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pathobiology of Emerging Pathogens in Laboratory Animals (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.389 National Center for Research Resources.
  • This funding opportunity was created on Jun 22, 2010 and posted on Jun 22, 2010.
  • Applicants must submit their applications by Aug 31, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
  • Eligible applicants include: State governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Small businesses Public and State controlled institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
Apply for RFA RR 10 005

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Opportunity Summary:

The Pathobiology of Emerging Pathogens in Laboratory Animals (R01) opportunity (Funding Opportunity Number RFA RR 10 005) was a National Institutes of Health grant announcement issued through the National Center for Research Resources (NCRR). Its main goal was to fund new research applications that focus on the pathobiology, meaning the biological mechanisms of disease and how disease develops, of emerging or potentially emerging pathogens that affect laboratory animals. The announcement explicitly highlights that the target species are not limited to just one area of biomedical research, but can include aquatic laboratory species, rodents, and nonhuman primates, reflecting a broad interest in infectious threats that could compromise animal health, animal-based research validity, and potentially biosecurity and public health.

The program used the NIH Research Project Grant (R01) mechanism, which is typically intended for well-developed research projects with clear aims, strong preliminary rationale, and a multi-year plan. This R01 announcement was designed to run in parallel with a separate, scientifically identical call (RFA RR 10 004) that encouraged applications under the R21 mechanism, which generally supports earlier-stage or more exploratory projects. In practical terms, the R01 version of the opportunity was aimed at investigators ready to pursue more comprehensive, hypothesis-driven studies into how emerging pathogens infect laboratory animals, how disease progresses, and what host-pathogen interactions drive pathology in relevant species.

For the 2011 funding cycle, NIH anticipated up to $2.5 million in total direct costs to support as many as five R01 awards. The opportunity fell under a discretionary grant category, with the funding instrument listed as a grant and the activity category aligned with education and health (CFDA 93.389). It did not require cost sharing or matching funds, which is common for NIH research project grants and reduces the burden on applicants to provide non-federal matching dollars.

Eligibility was broad and included many types of domestic and non-domestic organizations. Eligible applicants included federal, state, county, city/township, and special district governments; Native American tribal governments and tribal organizations (including federally recognized and other-than-federally recognized entities); public housing authorities/Indian housing authorities; public and private institutions of higher education; independent school districts; nonprofits both with and without 501(c)(3) status (with noted distinctions for institutions of higher education); and for-profit organizations including small businesses. The announcement also explicitly welcomed a range of mission-focused institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign (non-U.S.) entities.

Key administrative dates show that the FOA was posted and created on June 22, 2010, with an original and current closing date of August 31, 2010, and an archive date of October 1, 2010, indicating it was a time-limited solicitation. Applicants and interested parties were directed to the full announcement on the NIH grants site, and technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contacts.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled The Pathobiology of Emerging Pathogens in Laboratory Animals (R01).

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number listed is RFA RR 10 005.

Which federal agency issued this announcement?

This was a National Institutes of Health (NIH) grant announcement.

Which NIH center administered the opportunity?

The announcement was issued through the National Center for Research Resources (NCRR).

What is the main purpose of this FOA?

The main goal was to fund new research applications focused on the pathobiology of emerging or potentially emerging pathogens that affect laboratory animals.

What does "pathobiology" mean in the context of this announcement?

In this FOA, pathobiology refers to the biological mechanisms of disease and how disease develops and progresses in laboratory animals infected with emerging or potentially emerging pathogens.

What kinds of research topics were emphasized?

The announcement emphasized studies on how emerging pathogens infect laboratory animals, how disease progresses, and what host-pathogen interactions drive pathology in relevant laboratory species.

Which laboratory animal species were included?

The FOA highlighted that target species were broad and could include aquatic laboratory species, rodents, and nonhuman primates. The announcement also noted that the target species were not limited to one area of biomedical research.

Why was NIH interested in this research area?

The FOA described a broad interest in infectious threats that could compromise animal health, the validity of animal-based research, and potentially biosecurity and public health.

What grant mechanism was used for this opportunity?

This opportunity used the NIH Research Project Grant (R01) mechanism.

What type of project is the R01 mechanism generally intended to support?

As described, the R01 mechanism is typically intended for well-developed research projects with clear aims, a strong preliminary rationale, and a multi-year plan.

Was there a related opportunity for exploratory or early-stage projects?

Yes. This R01 announcement was designed to run in parallel with a separate, scientifically identical call: RFA RR 10 004, which encouraged applications under the R21 mechanism (generally used for earlier-stage or more exploratory projects).

How much funding was anticipated for the 2011 funding cycle?

For the 2011 funding cycle, NIH anticipated up to $2.5 million in total direct costs.

How many awards were expected?

NIH anticipated supporting as many as five R01 awards.

Does the FOA mention cost sharing or matching funds?

Yes. The opportunity did not require cost sharing or matching funds.

What is the funding instrument for this program?

The funding instrument is listed as a grant.

What category did this opportunity fall under?

The opportunity is described as a discretionary grant, with an activity category aligned with education and health.

What is the CFDA number associated with this opportunity?

The CFDA number provided is 93.389.

Who was eligible to apply?

Eligibility was described as broad, including many types of domestic and non-domestic organizations.

Are government entities eligible applicants?

Yes. Eligible applicants included federal, state, county, city/township, and special district governments.

Are tribal governments and tribal organizations eligible?

Yes. Eligible applicants included Native American tribal governments and tribal organizations, including both federally recognized and other-than-federally recognized entities.

Are public housing authorities eligible to apply?

Yes. Public housing authorities/Indian housing authorities were listed as eligible applicants.

Are colleges and universities eligible?

Yes. Both public and private institutions of higher education were listed as eligible.

Are independent school districts eligible?

Yes. Independent school districts were explicitly included in the eligibility list.

Are nonprofit organizations eligible?

Yes. Eligible applicants included nonprofits with and without 501(c)(3) status, with noted distinctions for institutions of higher education.

Are for-profit organizations eligible?

Yes. Eligibility included for-profit organizations, including small businesses.

Are foreign (non-U.S.) organizations eligible to apply?

Yes. The announcement explicitly included foreign (non-U.S.) entities among eligible applicants.

Did the FOA specifically welcome certain mission-focused institutions?

Yes. The announcement explicitly welcomed applications from organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others.

Were U.S. territories or possessions included in the eligibility language?

Yes. The eligibility language explicitly mentioned U.S. territories or possessions.

When was the FOA posted and created?

The FOA was posted and created on June 22, 2010.

What was the closing date for this opportunity?

The original and current closing date listed was August 31, 2010.

When was the FOA archived?

The archive date provided was October 1, 2010, indicating it was a time-limited solicitation.

Where were applicants directed for the full announcement?

Applicants and interested parties were directed to the full announcement on the NIH grants site.

Where should technical access issues be directed?

Technical access issues were routed to the NIH Office of Extramural Research (OER) webmaster contacts.

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