Opportunity Information: Apply for RFA RM 08 022
Apply for RFA RM 08 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Patient Reported Outcomes Measurement Information System (PROMIS) Network Center (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 4, 2008 and posted on Dec 4, 2008.
- Applicants must submit their applications by Mar 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments Private institutions of higher education For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions are not eligible to apply as the primary applicant but they may enter into collaborations with a domestic institution that is the primary applicant
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity RFA-RM-08-022 supports the creation of a single, centralized coordinating hub for the Patient Reported Outcomes Measurement Information System (PROMIS) effort, called the PROMIS Network Center (PNC). The core idea behind PROMIS is to strengthen and modernize how patient-reported outcomes (PROs) are developed, validated, and used in clinical research, so that investigators across many diseases and populations can rely on consistent, high-quality measurement tools. In this grant, NIH is not primarily looking for one more research project that happens to use PROs; it is looking for an organization capable of running and steering a national network resource that serves the broader clinical research community.
The PNC is expected to function as the operational backbone of the PROMIS Network. That means providing overall coordination, management, infrastructure, and leadership across participating centers and sites. A major emphasis is planning and managing the transition from PROMIS funding phase one to phase two, including the practical details of keeping the network productive while priorities, membership, and deliverables evolve. The PNC is also expected to support and report to the PROMIS Steering Committee, which oversees both scientific direction and administrative performance for the network. Because this is a cooperative agreement (U54), NIH anticipates substantial involvement with awardees; the funded center would work closely with NIH and the Steering Committee rather than operating in a fully independent, investigator-driven mode.
Programmatically, the PNC is tasked with helping the network set and execute a strategic plan and a research agenda aligned with NIH Roadmap (NIH RM) PROMIS goals and priorities. This includes tracking progress and ensuring the work stays focused on creating tools and standards that can be broadly adopted. A specific accountability area is monitoring data accrual and representativeness, with an explicit requirement to pay attention to inclusion of underserved populations. The announcement highlights a particular emphasis on research involving children, women, racial and ethnic minorities, and individuals with disabilities. In practice, this implies the Network Center would need processes for monitoring who is being represented in PROMIS data collections, identifying gaps, and coordinating corrective actions across sites so that resulting measures are valid and useful across diverse populations.
Another central responsibility is continuing the establishment and maintenance of PROMIS standards for domain development and clinical validation. PROMIS domains are essentially the health concepts being measured (for example, physical function, pain interference, fatigue, emotional distress), and the network’s value depends heavily on consistent methods for developing item banks, calibrating measures, validating them in relevant populations, and demonstrating clinical utility. The PNC’s role is to help the network keep these methods coherent and rigorous across multiple collaborating groups, so that PROMIS outputs remain interoperable, comparable, and trusted by outside users.
The PNC is also expected to drive collaboration-building beyond the immediate network. This includes planning and developing partnerships, likely with clinical research consortia, health systems, professional societies, and other groups that can help PROMIS measures spread into real-world studies. Alongside that outward-facing work, the opportunity stresses the importance of planning for sustainability, with the expectation that the network transitions to a sustainable funding structure by the end of the next PROMIS project period (noted as FY2012). In other words, NIH wanted applicants to think beyond short-term grant deliverables and to propose a realistic path for keeping PROMIS functioning and updated after the immediate award period, potentially through diversified funding, service models, partnerships, or integration into other long-term NIH-supported infrastructure.
From an administrative standpoint, this opportunity is a discretionary NIH cooperative agreement in the health category, with an expected single award. The estimated total funding level listed is $600,000. There is no cost-sharing or matching requirement. The opportunity was posted December 4, 2008, with an original and current closing date of March 3, 2009, and an archive date of April 3, 2009, indicating it is an older, time-limited solicitation rather than an open, recurring program announcement.
Eligibility is broad for a federal research opportunity and includes many types of domestic organizations, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses are explicitly mentioned as eligible, and small businesses are also listed), state and local governments, tribal governments and tribal organizations, independent school districts, public housing authorities, and special district governments. The announcement also notes additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions are not eligible to apply as the primary applicant, but they may collaborate if a domestic institution serves as the lead applicant.
In practical terms, a competitive application for this kind of Network Center would need to convince NIH that the applicant can run a complex multi-site program with strong governance, clear communication pathways, reliable project management, and credible scientific leadership in patient-reported outcomes measurement. It would also need to show how the applicant would support the Steering Committee, maintain and advance PROMIS methodological standards, coordinate collaborations, monitor inclusion and representativeness in data, and guide the network through a planned transition to phase two and toward longer-term sustainability. The full announcement and requirements were made available through the NIH Grants Guide (link provided in the opportunity), with technical assistance for access handled through the NIH Office of Extramural Research webmaster contacts.
FAQs: NIH RFA-RM-08-022 (PROMIS Network Center)
What is NIH RFA-RM-08-022?
RFA-RM-08-022 is a National Institutes of Health (NIH) funding opportunity to support the creation of a single, centralized coordinating hub for the Patient Reported Outcomes Measurement Information System (PROMIS) effort. The funded hub is called the PROMIS Network Center (PNC).
What is PROMIS in this funding opportunity?
PROMIS (Patient Reported Outcomes Measurement Information System) is an NIH Roadmap effort intended to strengthen and modernize how patient-reported outcomes (PROs) are developed, validated, and used in clinical research. The goal is to enable investigators across many diseases and populations to use consistent, high-quality measurement tools.
What is the PROMIS Network Center (PNC)?
The PNC is the operational backbone of the PROMIS Network. It is expected to provide overall coordination, management, infrastructure, and leadership across participating centers and sites, helping the network function as a shared national resource.
Is this opportunity funding a typical research project?
No. NIH is not primarily seeking another individual research project that uses patient-reported outcomes. The opportunity is aimed at an organization that can run and steer a national network resource that serves the broader clinical research community.
What type of NIH award mechanism is used?
This opportunity uses a cooperative agreement mechanism (U54). Under a cooperative agreement, NIH anticipates substantial involvement with awardees, meaning the funded center would work closely with NIH and the PROMIS Steering Committee.
How many awards does NIH expect to make?
The announcement indicates an expected single award, meaning NIH planned to fund one organization to serve as the centralized Network Center.
What is the estimated total funding amount?
The estimated total funding level listed in the opportunity is $600,000.
Is there a cost-sharing or matching requirement?
No. The opportunity states there is no cost-sharing or matching requirement.
What are the main responsibilities of the PNC?
Based on the announcement summary, the PNC is expected to:
- Provide overall coordination, management, infrastructure, and leadership for the PROMIS Network.
- Support and report to the PROMIS Steering Committee, which oversees scientific direction and administrative performance.
- Plan and manage the transition from PROMIS funding phase one to phase two while keeping the network productive as priorities, membership, and deliverables evolve.
- Help the network set and execute a strategic plan and research agenda aligned with NIH Roadmap PROMIS goals and priorities.
- Track progress to keep work focused on broadly adoptable tools and standards.
- Monitor data accrual and representativeness, including attention to underserved populations.
- Continue establishment and maintenance of PROMIS standards for domain development and clinical validation.
- Build collaborations beyond the immediate network and plan partnerships to expand PROMIS measure use in real-world studies.
- Plan for sustainability, with an expectation of transitioning to a sustainable funding structure by the end of the next PROMIS project period (noted as FY2012).
What is the role of the PROMIS Steering Committee?
The PROMIS Steering Committee oversees both the scientific direction and administrative performance of the network. The PNC is expected to support and report to the Steering Committee.
What does “transition from phase one to phase two” mean in this context?
The opportunity emphasizes planning and managing the transition between PROMIS funding phases. This includes managing practical details so the network remains productive while priorities, membership, and deliverables evolve during phase two.
What does NIH mean by “standards for domain development and clinical validation”?
In PROMIS, “domains” are the health concepts being measured (examples provided include physical function, pain interference, fatigue, and emotional distress). The PNC is expected to help the network maintain consistent, rigorous methods for developing item banks, calibrating measures, validating them in relevant populations, and demonstrating clinical utility so PROMIS outputs remain interoperable, comparable, and trusted by outside users.
What is the PNC expected to do about inclusion and representativeness?
The PNC has an explicit accountability area to monitor data accrual and representativeness and to pay attention to inclusion of underserved populations. The announcement highlights emphasis on research involving children, women, racial and ethnic minorities, and individuals with disabilities. Practically, this implies processes to monitor representation in PROMIS data collection, identify gaps, and coordinate corrective actions across sites.
Which populations are specifically emphasized for inclusion?
The opportunity highlights particular emphasis on children, women, racial and ethnic minorities, and individuals with disabilities, along with an explicit requirement to pay attention to underserved populations.
What kinds of collaborations is the PNC expected to build?
The opportunity states the PNC should drive collaboration-building beyond the immediate PROMIS network. This includes planning and developing partnerships, likely with clinical research consortia, health systems, professional societies, and other groups that can help PROMIS measures spread into real-world studies.
What does the opportunity say about sustainability?
The opportunity stresses sustainability planning, with an expectation that the PROMIS network transitions to a sustainable funding structure by the end of the next PROMIS project period (noted as FY2012). Applicants were expected to propose a realistic path for keeping PROMIS functioning and updated after the award period, potentially via diversified funding, service models, partnerships, or integration into other long-term NIH-supported infrastructure.
When was this opportunity posted and when did it close?
The opportunity was posted on December 4, 2008. The original and current closing date is March 3, 2009. The archive date is April 3, 2009, indicating it was time-limited and is now archived.
Is this an open, recurring program announcement?
No. The dates provided (including an archive date) indicate it was an older, time-limited solicitation rather than an open, recurring program announcement.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations, including:
- Public and private institutions of higher education
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations (small businesses are listed as eligible, and for-profits other than small businesses are also explicitly mentioned as eligible)
- State and local governments
- Tribal governments and tribal organizations
- Independent school districts
- Public housing authorities
- Special district governments
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribal Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply as the primary applicant. However, they may collaborate if a domestic institution serves as the lead applicant.
What would a competitive application need to demonstrate?
The opportunity indicates that a competitive application would need to convince NIH that the applicant can run a complex multi-site program, including strong governance, clear communication pathways, reliable project management, and credible scientific leadership in patient-reported outcomes measurement. It would also need to describe how the applicant would support the Steering Committee, maintain and advance PROMIS methodological standards, coordinate collaborations, monitor inclusion and representativeness, and guide the network through the transition to phase two and toward sustainability.
Where was the full announcement made available?
The full announcement and requirements were made available through the NIH Grants Guide, with technical assistance for access handled through NIH Office of Extramural Research webmaster contacts (as referenced in the opportunity summary).
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