Opportunity Information: Apply for RFA RM 08 023
Apply for RFA RM 08 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Patient Reported Outcomes Measurement Information System (PROMIS) Research Sites (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 4, 2008 and posted on Dec 4, 2008.
- Applicants must submit their applications by Mar 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,650,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments State governments Special district governments Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Patient Reported Outcomes Measurement Information System (PROMIS) Research Sites (U01) funding opportunity (RFA-RM-08-023) is a National Institutes of Health (NIH) initiative designed to expand and strengthen PROMIS as a shared national resource for clinical research. PROMIS focuses on patient-reported outcomes (PROs), meaning standardized ways to measure what patients say about their health, symptoms, functioning, and well-being. Under this announcement, NIH sought research teams that could help grow PROMIS by either creating entirely new measurement domains (following PROMIS item bank development methods) or by validating existing or newly developed PROMIS item banks in real-world clinical populations. The overall aim is to ensure that PROMIS tools are scientifically solid, broadly usable across diseases and settings, and capable of supporting more precise and meaningful outcome measurement in clinical studies.
Projects funded through this opportunity were expected to contribute directly to the PROMIS Network, a collaborative structure made up of existing and newly added centers. Awardees would not work in isolation; they would operate as part of a coordinated network intended to accelerate progress through shared methods, harmonized standards, and cooperative problem-solving. The emphasis on collaboration reflects PROMIS being positioned as infrastructure for the wider research community, not just a set of tools developed for one-off studies. In practice, this means research sites would help refine measurement science, improve how PRO data are captured and interpreted, and support the broader adoption of PROMIS measures in clinical research and, potentially, clinical practice.
The grant mechanism used was the U01 Cooperative Agreement, which signals a more hands-on partnership with NIH compared to a typical investigator-initiated research grant. Under a cooperative agreement, NIH generally has substantial programmatic involvement, such as coordinating across awardees, setting network expectations, and aligning projects with PROMIS-wide milestones and deliverables. This FOA was part of a larger suite of four interrelated announcements supporting the second phase of the NIH Roadmap PROMIS Initiative, and it ran in parallel with three related U54 awards (RFA-RM-08-022, RFA-RM-08-024, and RFA-RM-08-025) that shared an interconnected scientific scope. Taken together, the structure indicates NIH was building a coordinated ecosystem: multiple award types working together to advance PROMIS measurement development, testing, validation, and dissemination.
From a funding and scale standpoint, NIH anticipated total funding of about $5.65 million in total costs per year for new awards under this initiative, with an expected 5 to 10 awards in fiscal year 2009. The opportunity did not require cost sharing or matching. The program falls under CFDA 93.310 (Trans-NIH Research Support), reflecting its cross-cutting, NIH-wide relevance rather than being tied to a single institute’s disease area.
Eligibility was broad and intentionally inclusive, spanning public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities (state, county, city/township, special districts, and certain housing authorities). It also explicitly included Tribal governments and organizations, Tribally Controlled Colleges and Universities, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. This broad eligibility aligns with PROMIS goals: to validate and expand PRO measurement across diverse populations, healthcare contexts, and research environments.
Key dates show this was a time-limited solicitation: it was posted and created on December 4, 2008, with an original and current closing date of March 3, 2009, and an archive date of April 3, 2009. Additional details and the full announcement were hosted by NIH at the listed RFA link (grants.nih.gov). For access or technical issues, NIH directed applicants to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs): PROMIS Research Sites (U01) - RFA-RM-08-023
What is the PROMIS Research Sites (U01) funding opportunity?
The PROMIS Research Sites (U01) funding opportunity (RFA-RM-08-023) was a National Institutes of Health (NIH) initiative to expand and strengthen the Patient Reported Outcomes Measurement Information System (PROMIS) as a shared national resource for clinical research.
What does PROMIS focus on?
PROMIS focuses on patient-reported outcomes (PROs), meaning standardized ways to measure what patients report about their health, symptoms, functioning, and well-being.
What was the overall purpose of this NIH initiative?
The overall aim was to ensure PROMIS tools are scientifically sound, broadly usable across diseases and settings, and able to support more precise and meaningful outcome measurement in clinical studies.
What types of projects were NIH seeking under this announcement?
NIH sought research teams that could help grow PROMIS in one of two main ways: (1) create entirely new measurement domains using PROMIS item bank development methods, or (2) validate existing or newly developed PROMIS item banks in real-world clinical populations.
What does it mean to create "new measurement domains" for PROMIS?
Based on the description, creating new measurement domains meant developing entirely new areas of patient-reported outcome measurement and building item banks using PROMIS development methods.
What does "validating item banks in real-world clinical populations" involve?
It refers to testing existing or newly developed PROMIS item banks in actual clinical populations to confirm they perform well in practical, real-world settings.
Were awardees expected to work independently or collaboratively?
Awardees were expected to contribute directly to the PROMIS Network and operate as part of a coordinated, collaborative network rather than working in isolation.
What is the PROMIS Network in the context of this opportunity?
The PROMIS Network was described as a collaborative structure made up of existing and newly added centers working together to accelerate progress through shared methods, harmonized standards, and cooperative problem-solving.
Why was collaboration emphasized so strongly?
Collaboration was emphasized because PROMIS was positioned as research infrastructure for the wider community, not as tools developed only for one-off studies. The network model was intended to accelerate development, testing, and adoption through coordinated work.
What grant mechanism was used for this opportunity?
This opportunity used the U01 Cooperative Agreement mechanism.
How is a U01 Cooperative Agreement different from a typical research grant?
The U01 mechanism signals a more hands-on partnership with NIH than a typical investigator-initiated grant. NIH generally has substantial programmatic involvement, such as coordinating across awardees, setting network expectations, and aligning projects with PROMIS-wide milestones and deliverables.
What role did NIH have under the cooperative agreement structure?
NIH was expected to have substantial programmatic involvement, including coordinating across awardees and aligning projects with network expectations, milestones, and deliverables.
Was this opportunity part of a larger PROMIS effort?
Yes. This FOA was part of a larger suite of four interrelated announcements supporting the second phase of the NIH Roadmap PROMIS Initiative.
Were there related funding announcements connected to this one?
Yes. This U01 announcement ran in parallel with three related U54 awards: RFA-RM-08-022, RFA-RM-08-024, and RFA-RM-08-025, which were described as sharing an interconnected scientific scope.
What does it mean that the U01 and U54 awards were interconnected?
It indicates NIH was building a coordinated ecosystem of multiple award types working together to advance PROMIS measurement development, testing, validation, and dissemination.
How much funding did NIH anticipate for new awards under this initiative?
NIH anticipated total funding of about $5.65 million in total costs per year for new awards under this initiative.
How many awards were expected?
NIH expected approximately 5 to 10 awards in fiscal year 2009.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
What CFDA number was associated with this program?
The program fell under CFDA 93.310 (Trans-NIH Research Support).
What does the CFDA listing suggest about the program's scope?
Being listed under Trans-NIH Research Support suggests the program was cross-cutting and NIH-wide in relevance, rather than tied to a single institute or disease area.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education, nonprofit organizations (501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities.
What types of government entities were included as eligible applicants?
Eligible government entities included state, county, city/township, special district governments, and certain housing authorities, as well as eligible federal agencies.
Were Tribal entities and organizations eligible?
Yes. The eligibility list explicitly included Tribal governments and organizations, as well as Tribally Controlled Colleges and Universities.
Were minority-serving institutions specifically included?
Yes. The eligibility list explicitly included HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities.
Could faith-based and community-based organizations apply?
Yes. Faith-based and community-based organizations were explicitly included in the eligibility list.
Could organizations in U.S. territories or possessions apply?
Yes. U.S. territories or possessions were explicitly included in the eligibility list.
Why was eligibility so broad for this opportunity?
The broad eligibility aligned with PROMIS goals to validate and expand patient-reported outcome measurement across diverse populations, healthcare contexts, and research environments.
When was the opportunity posted and when did it close?
It was posted and created on December 4, 2008. The original and current closing date was March 3, 2009.
When was the opportunity archived?
The archive date was April 3, 2009.
Is this funding opportunity still active?
No. Based on the listed closing date (March 3, 2009) and archive date (April 3, 2009), this was a time-limited solicitation and is no longer active.
Where were applicants directed to find the full announcement details?
Additional details and the full announcement were hosted by NIH at the RFA link on grants.nih.gov.
Who should applicants contact for access or technical issues related to the announcement website?
For access or technical issues, NIH directed applicants to contact the NIH Office of Extramural Research (OER) webmaster.
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