Opportunity Information: Apply for RFA RM 08 024
Apply for RFA RM 08 024
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Patient Reported Outcomes Measurement Information System (PROMIS) Technology Center (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 4, 2008 and posted on Dec 4, 2008.
- Applicants must submit their applications by Mar 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Small businesses State governments Independent school districts County governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions are not eligible to apply as the primary applicant but they may enter into collaborations with a domestic institution that is the primary applicant.
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Opportunity Summary:
The Patient Reported Outcomes Measurement Information System (PROMIS) Technology Center (PTC) (U54) funding opportunity (RFA-RM-08-024) is a National Institutes of Health (NIH) initiative aimed at building a central technology hub within the broader PROMIS Network. PROMIS is designed to be a shared resource for clinical researchers who need reliable, standardized tools to measure patient-reported outcomes (PROs), such as symptoms, functioning, and quality of life. The core idea behind this opportunity is to strengthen the technology and informatics backbone that allows PROMIS measures to be administered efficiently and consistently across many types of clinical studies.
The main purpose of the PROMIS Technology Center is to research, develop, and deliver computer-based administration services for PROMIS item banks. A major emphasis is on computer adaptive testing (CAT), which uses algorithms to select the most informative next question based on a participant's previous answers, reducing respondent burden while maintaining measurement precision. In addition to CAT, the center is expected to support web-based access to PROMIS short forms and enable other administration approaches, reflecting the real-world needs of clinical research settings where studies may vary in staffing, connectivity, devices, and workflow constraints. In practice, this means the Technology Center is expected to make PROMIS instruments easier to deploy and manage, whether a study uses a dynamic CAT assessment, a fixed short form, or a mix of modalities.
Another defining feature of this opportunity is that the center is not meant to serve only PROMIS investigators. While it will support the internal CAT and informatics needs of the PROMIS Network, it is also expected to provide these technology services to the wider research community. This positions the award as infrastructure-like: the deliverables are tools, systems, and services that allow many outside groups to use PROMIS measures correctly and efficiently in their own clinical research. The center will also be part of a collaborative network of existing and newly funded sites, working together to advance technologies that improve how PROs are measured and applied in clinical research, consistent with the NIH Roadmap goals for modernizing clinical research tools.
This announcement uses the U54 Research Center Cooperative Agreement mechanism. A cooperative agreement differs from a standard grant in that NIH typically has substantial programmatic involvement, which fits a networked, platform-building project where coordination, shared standards, and interoperability matter. The opportunity was released in parallel with other related PROMIS funding announcements (two other U54s and one U01), indicating NIH was building a coordinated set of components across the PROMIS initiative rather than funding a single stand-alone project.
In terms of scale and competition, NIH anticipated making a single award, with an estimated total funding level of about $600,000 per year in total costs, with the expected award made in FY2009. The posting date was December 4, 2008, and the application closing date was March 3, 2009 (with archiving on April 3, 2009), which reflects a time-limited solicitation intended to establish or designate one primary technology center for the network during that funding cycle.
Eligibility was broad and included many types of domestic organizations: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a range of governmental entities (state, county, city/township, special district, and independent school districts). The announcement also explicitly included institutions serving specific populations (for example, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions), as well as faith-based or community-based organizations and certain regional organizations. Foreign institutions could not apply as the primary applicant, but they were allowed to participate through collaborations if a domestic institution served as the lead. No cost sharing or matching was required.
Overall, this grant opportunity is best understood as NIH seeking one well-qualified, technically capable center to run and evolve the computing and informatics services that make PROMIS practical at scale. The center would be responsible for enabling modern, efficient administration of PROMIS measures (especially CAT), supporting both PROMIS Network projects and external researchers, and collaborating across the broader PROMIS initiative to ensure that patient-reported outcomes can be collected and used consistently, accurately, and with minimal burden in clinical research.
FAQs: PROMIS Technology Center (PTC) (U54) - RFA-RM-08-024
What is this funding opportunity?
This opportunity funds the Patient Reported Outcomes Measurement Information System (PROMIS) Technology Center (PTC) under NIH funding opportunity RFA-RM-08-024. It is intended to create a central technology hub within the broader PROMIS Network.
What is PROMIS, and why does it matter for clinical research?
PROMIS is a shared resource for clinical researchers who need reliable, standardized tools to measure patient-reported outcomes (PROs). These outcomes include areas such as symptoms, functioning, and quality of life. The goal is to make PRO measurement more consistent and useful across many kinds of clinical studies.
What is the main purpose of the PROMIS Technology Center (PTC)?
The PTC is expected to research, develop, and deliver computer-based administration services for PROMIS item banks. In practical terms, it strengthens the technology and informatics backbone needed to administer PROMIS measures efficiently and consistently across studies.
What are PROMIS item banks?
Based on the information provided, PROMIS item banks are sets of questions (items) used to measure patient-reported outcomes like symptoms, functioning, and quality of life. The Technology Center is focused on enabling computer-based administration of these item banks.
What types of PROMIS instrument administration does the center need to support?
The center is expected to support multiple approaches, including computer adaptive testing (CAT) and web-based access to PROMIS short forms. It should also enable other administration approaches to fit real-world research settings that differ in staffing, connectivity, devices, and workflow constraints.
What is computer adaptive testing (CAT) in this context?
CAT is a computer-based approach that uses algorithms to choose the most informative next question based on a participant's earlier answers. This is meant to reduce respondent burden while maintaining measurement precision.
Why is there a major emphasis on CAT?
The emphasis is because CAT can shorten assessments by selecting targeted questions while preserving precision, which can make PROMIS measures easier to use at scale and less burdensome for respondents.
Does the Technology Center only serve PROMIS investigators?
No. While the center will support the internal CAT and informatics needs of the PROMIS Network, it is also expected to provide these technology services to the wider research community. The deliverables are meant to help many outside groups use PROMIS measures correctly and efficiently in their own clinical research.
What kinds of deliverables are implied by this opportunity?
The award is positioned as infrastructure-like. Deliverables are described as tools, systems, and services that enable correct and efficient use of PROMIS measures, including technology to administer item banks via CAT and to provide web-based access to short forms, along with support for other administration modalities.
How does this opportunity relate to the broader PROMIS initiative?
The Technology Center is part of a collaborative network of existing and newly funded sites. It is expected to work with others to advance technologies that improve how patient-reported outcomes are measured and applied in clinical research, consistent with NIH Roadmap goals for modernizing clinical research tools.
What funding mechanism is used for this award?
This announcement uses the U54 Research Center Cooperative Agreement mechanism.
What does it mean that this is a cooperative agreement (U54) rather than a standard grant?
A cooperative agreement differs from a standard grant because NIH typically has substantial programmatic involvement. That structure fits a networked, platform-building effort where coordination, shared standards, and interoperability are important.
How many awards did NIH anticipate making?
NIH anticipated making a single award.
What was the expected funding level?
The estimated total funding level was about $600,000 per year in total costs.
When was the expected award timing?
The expected award was to be made in FY2009.
What were the key dates for this opportunity?
The posting date was December 4, 2008. The application closing date was March 3, 2009. The announcement was archived on April 3, 2009.
Was this a standing program or a time-limited solicitation?
It is described as time-limited, with a defined posting date, application closing date, and an archiving date, and it was intended to establish or designate one primary technology center for that funding cycle.
What types of organizations were eligible to apply?
Eligibility was broad and included many types of domestic organizations, including public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a range of governmental entities (state, county, city/township, special district, and independent school districts).
Were any specific institution types explicitly included?
Yes. The announcement explicitly included institutions serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions. It also included faith-based or community-based organizations and certain regional organizations.
Can a foreign institution apply as the primary applicant?
No. Foreign institutions could not apply as the primary applicant.
Can foreign institutions participate in any way?
Yes. Foreign institutions were allowed to participate through collaborations if a domestic institution served as the lead.
Was cost sharing or matching required?
No. The opportunity stated that no cost sharing or matching was required.
What is the overall goal NIH was pursuing with this award?
NIH was seeking one well-qualified, technically capable center to run and evolve the computing and informatics services that make PROMIS practical at scale. The center would enable efficient administration of PROMIS measures (especially CAT), support both PROMIS Network projects and external researchers, and collaborate across the broader PROMIS initiative to promote consistent, accurate, and low-burden PRO collection in clinical research.
Were there related PROMIS funding announcements at the same time?
Yes. This opportunity was released in parallel with other related PROMIS funding announcements (two other U54s and one U01), reflecting a coordinated approach to building PROMIS components rather than funding a single stand-alone project.
Why is interoperability and coordination highlighted for this center?
Because the center supports a networked, shared-resource ecosystem. The cooperative agreement structure and the description of a collaborative network indicate the work requires shared standards, interoperability, and coordination across sites and users.
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