Opportunity Information: Apply for RFA NR 11 004
Apply for RFA NR 11 004
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Jan 11, 2011 and posted on Jan 11, 2011.
- Applicants must submit their applications by Apr 18, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Special district governments County governments City or township governments For profit organizations other than small businesses Private institutions of higher education State governments Public housing authorities/Indian housing authorities Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Personalized Genomics for Symptom Management: Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21)" is a National Institutes of Health (NIH) funding announcement issued by the National Institute of Nursing Research (NINR). Its central goal is to push research beyond basic genomic findings and into practical, patient-centered symptom management for people living with chronic disorders. The emphasis is on connecting what is learned about genomic variation to real differences in how symptoms begin, how intense they become, how long they last, and how patients respond to therapies intended to prevent or relieve those symptoms. In other words, the program is looking for early-stage, exploratory projects that help explain why two patients with the same chronic condition can experience very different symptom burdens and treatment outcomes, and how that knowledge can be used to improve care.
A major focus of the opportunity is understanding the role of genomic variants in individual differences in symptom experiences and therapeutic response. Applicants are invited to examine how genetic differences may contribute to variation in symptom onset (when symptoms start), sensitivity (how easily symptoms are triggered), duration (how long they persist), and severity (how disruptive or intense they are). The program also explicitly includes responses to symptom-focused treatments, meaning research can investigate why some individuals benefit from a given intervention while others see limited improvement or experience side effects. This positions the funding squarely in the space of personalized or precision approaches to symptom management, where biological variation is treated as a key driver of heterogeneity in patient outcomes.
At the same time, the announcement makes it clear that genomics is not the whole story. A second, equally important component is the investigation of non-genomic influences that may shape, interact with, or moderate the effects of genomic variants on symptoms and treatment response. These non-genomic factors can include a wide range of influences such as environmental exposures, behavioral factors, psychosocial stressors, lifestyle, comorbidities, socioeconomic context, and other clinical or contextual variables. The underlying idea is that genetic risk or genetic responsiveness often depends on the context in which a person lives and receives care, and the most useful research will help clarify how genes and non-genomic factors work together to influence symptom trajectories.
The expected payoff from this line of research is a stronger evidence base for identifying which individuals are at highest risk for severe, persistent, or difficult-to-treat symptoms in chronic illness. By clarifying the genomic and non-genomic contributors to symptom patterns, the results are intended to support the future development or targeting of customized therapeutics and interventions. The announcement frames this as tailoring care to an individual's genomic profile, which implies a longer-term vision in which symptom prevention and management strategies can be selected, adapted, or timed based on biological susceptibility and predicted response.
From an administrative standpoint, this opportunity is a discretionary grant using the NIH R21 mechanism, which is typically used to support exploratory or developmental research projects that may generate new approaches, preliminary data, or proof-of-concept findings. The Funding Opportunity Number is RFA-NR-11-004, and it falls under CFDA 93.361 (Nursing Research). The award ceiling is listed as $200,000, and the opportunity does not require cost sharing or matching funds. The announcement was posted on January 11, 2011, with an original and current closing date of April 18, 2011, and an archive date of May 19, 2011, indicating that it was time-limited and is now archived.
Eligibility is broad and includes many types of applicant organizations. Eligible applicants include federal, state, local, and tribal governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (with certain distinctions for institutions of higher education); for-profit organizations other than small businesses; and small businesses. The eligibility list also explicitly includes a range of mission-serving and community-based entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. This broad eligibility aligns with the translational and population-relevant nature of symptom management research, where meaningful studies may be carried out across academic medical centers, community settings, and diverse patient populations.
For applicants or interested parties seeking the full announcement details, the opportunity points to the NIH grants guide page associated with RFA-NR-11-004. For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, specifically for difficulties accessing the posting or problems with links to the funding announcement.
Frequently Asked Questions (FAQs)
What is the "Personalized Genomics for Symptom Management: Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21)" opportunity?
This is a National Institutes of Health (NIH) funding announcement from the National Institute of Nursing Research (NINR) focused on exploratory research that connects genomic discovery to practical, patient-centered symptom management for people living with chronic disorders.
Which NIH institute is sponsoring this funding announcement?
The opportunity is issued by the National Institute of Nursing Research (NINR) under the NIH.
What is the main goal of the program?
The central goal is to move beyond basic genomic findings and support early-stage projects that clarify how genomic variation relates to real-world differences in symptom experiences and responses to symptom-focused therapies, with an emphasis on improving health outcomes for individuals with chronic disorders.
What kinds of research questions does the announcement prioritize?
It prioritizes questions that help explain why individuals with the same chronic condition can experience very different symptom burdens and treatment outcomes, and how knowledge about genomic and non-genomic influences can be used to improve symptom prevention and management.
How does the announcement define symptom differences that may be studied?
The announcement highlights differences in symptom onset (when symptoms start), sensitivity (how easily symptoms are triggered), duration (how long they persist), and severity (how disruptive or intense they are).
Does the opportunity include research on treatment response?
Yes. It explicitly includes responses to symptom-focused treatments, including investigating why some people benefit from an intervention while others improve less or experience side effects.
Is the focus only on genomics?
No. While genomic variants are a major focus, the announcement also emphasizes non-genomic influences that may shape, interact with, or moderate genomic effects on symptoms and treatment response.
What are examples of non-genomic factors mentioned in the announcement?
Examples include environmental exposures, behavioral factors, psychosocial stressors, lifestyle, comorbidities, socioeconomic context, and other clinical or contextual variables.
What does "personalized" or "precision" symptom management mean in the context of this announcement?
It refers to approaches that treat biological variation as a driver of differences in symptom burden and therapeutic response, with a longer-term vision of tailoring symptom prevention and management strategies based on an individual's genomic profile and relevant contextual factors.
What is the expected payoff or impact of the research supported by this opportunity?
The intended payoff is a stronger evidence base for identifying individuals at higher risk for severe, persistent, or difficult-to-treat symptoms in chronic illness, supporting future development or targeting of customized therapeutics and interventions.
What funding mechanism is used for this opportunity?
This opportunity uses the NIH R21 mechanism, which supports exploratory or developmental research projects that can generate new approaches, preliminary data, or proof-of-concept findings.
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA-NR-11-004.
What CFDA number is associated with this grant opportunity?
The opportunity is associated with CFDA 93.361 (Nursing Research).
What is the maximum award amount (award ceiling) listed?
The award ceiling listed for this opportunity is $200,000.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching funds are not required.
When was the opportunity posted?
The announcement was posted on January 11, 2011.
What was the closing date for applications?
The original and current closing date listed is April 18, 2011.
Is this funding opportunity still open?
No. The announcement is time-limited and is now archived. It lists an archive date of May 19, 2011.
Who is eligible to apply?
Eligibility is broad and includes federal, state, local, and tribal governments; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, with distinctions for institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are mission-serving or community-based organizations included in the eligible applicant types?
Yes. The eligibility list explicitly includes entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Where can applicants find the full funding announcement details?
The opportunity points applicants to the NIH grants guide page associated with RFA-NR-11-004 for full announcement details.
Who should be contacted for technical problems accessing the announcement?
For technical issues accessing the posting or problems with links to the funding announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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