Opportunity Information: Apply for PAR 08 155

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "PHASE II Comprehensive ICOHRTA AIDS/TB (U2R)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs 93.282 Mental Health National Research Service Awards for Research Training 93.865 Child Health and Human Development Extramural Research 93.989 International Research and Research Training.
  • This funding opportunity was created on Dec 2, 2008 and posted on Dec 2, 2008.
  • Applicants must submit their applications by Aug 18, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $275,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) New applications for a Phase II Comprehensive ICOHRTA AIDS/TB Award will only be accepted from foreign institutions that were awarded a planning grant under Phase I ICOHRTA AIDS TB program announcement and the U.S. non profit partner institution that the planning grant recipient has chosen. The foreign and U.S. partner applicant institutions must have achieved a strong record of receiving or being significantly involved in HIV/AIDS and/or TB international research. Both the foreign and U.S. partner institutions must demonstrate the capacity and leadership necessary for the successful implementation and long term productivity of the program. Renewal applications will only be accepted from existing ICOHRTA AIDS TB recipients. Any changes in applicant institutions for U.S. partners need to be well justified.
Apply for PAR 08 155

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Opportunity Summary:

PAR 08 155, titled "PHASE II Comprehensive ICOHRTA AIDS/TB (U2R)," is a National Institutes of Health (NIH) cooperative agreement funding opportunity designed to build and sustain research training capacity in countries heavily affected by HIV and tuberculosis. It is part of the International Clinical, Operations and Health Services Research Training Award for AIDS and TB (ICOHRTA AIDS/TB) program and is specifically aimed at moving programs beyond the initial planning phase into a fully implemented, comprehensive training effort. The FOA was issued by the Fogarty International Center (FIC) in collaboration with the National Institute of Mental Health (NIMH), the Office of Research on Women's Health (ORWH), and the National Institute on Drug Abuse (NIDA), reflecting an emphasis not only on biomedical and clinical issues but also on behavioral, social, and health systems factors that shape HIV/TB outcomes.

The core purpose is to support an integrated training program that measurably strengthens a foreign institution's ability to conduct high-quality clinical research and implementation science. This includes operations research and health services research focused on HIV infection and TB and, where relevant, prevention, care, and treatment for HIV/TB coinfection. In practical terms, the program is meant to develop local expertise and leadership so that research questions, study execution, and translation of findings into real-world health programs can increasingly be led within the partner country, rather than relying primarily on external investigators. The emphasis on implementation science signals that NIH wants trainees to learn how to evaluate and improve the delivery of proven interventions in real settings, such as clinics and community programs, including issues like adherence, retention in care, service integration, and program performance.

Funding is provided through the International Training Cooperative Agreement (U2R) mechanism. As a cooperative agreement, this mechanism generally implies substantial NIH involvement compared to a standard grant, meaning awardees should expect active programmatic collaboration and oversight consistent with cooperative agreement norms. The total estimated funding available for fiscal year 2009 is $3,000,000, with an anticipated five to six awards supporting either new Phase II programs or renewals of existing ICOHRTA AIDS/TB Research Training Units. Individual awards have an indicated ceiling of $275,000. Future funding levels are contingent on annual appropriations, so multi-year continuity depends on federal budget decisions as well as satisfactory program performance.

A notable administrative condition is the cap on facilities and administrative (F&A) costs, which are limited to 8% for all awards and subawards. This restriction is common in certain international training programs and signals that NIH expects the majority of the budget to go directly toward programmatic training and research capacity-building activities rather than indirect institutional costs. The earliest anticipated start date for awards under this cycle was April 1, 2009. The FOA was posted on December 2, 2008, with an application deadline of August 18, 2009, and an archive date of September 18, 2009.

Eligibility is tightly defined for new Phase II applications. New applications are only accepted from foreign institutions that previously received a Phase I ICOHRTA AIDS/TB planning grant, together with the specific U.S. nonprofit partner institution selected during Phase I. In other words, applicants must already be part of an established Phase I planning partnership and are expected to convert that plan into an operational, comprehensive training program. Renewal applications are limited to current ICOHRTA AIDS/TB awardees, and any proposed change in the U.S. partner institution must be strongly justified. Both the foreign and U.S. partner institutions are expected to demonstrate a strong track record of receiving or being significantly involved in HIV/AIDS and/or TB international research and must show clear leadership and capacity to implement the program successfully and maintain productivity over the long term.

The FOA sits within multiple federal program areas, as reflected by the CFDA numbers associated with drug abuse and addiction research, mental health research training, child health and human development extramural research, and international research and research training. This mix reinforces the broad view NIH is taking: HIV and TB research training is not limited to infectious disease clinical trials, but also includes mental health, substance use, women's health considerations, and health system performance, all of which can strongly influence prevention and treatment outcomes.

Overall, this opportunity is best understood as a second-stage, comprehensive capacity-building award that helps formalize and scale a training pipeline in a partner country. The expectation is that the Research Training Unit, formed by the Phase I foreign awardee and its U.S. partner, will deliver an integrated training program that prepares researchers to conduct rigorous clinical research and implementation/operations/health services studies, while also strengthening institutional structures needed for sustained research productivity in HIV, TB, and HIV/TB coinfection.

FAQs: PAR-08-155 - PHASE II Comprehensive ICOHRTA AIDS/TB (U2R)

What is PAR-08-155?

PAR-08-155 is a National Institutes of Health (NIH) cooperative agreement funding opportunity titled "PHASE II Comprehensive ICOHRTA AIDS/TB (U2R)." It supports a second-stage, fully implemented research training program focused on HIV and tuberculosis (TB), including HIV/TB coinfection, in countries heavily affected by these diseases.

What does "Phase II Comprehensive" mean in this program?

"Phase II Comprehensive" indicates the program is intended to move beyond an initial planning stage and into a fully operational, integrated training effort. The goal is to implement and scale a comprehensive training pipeline and strengthen institutional capacity for sustained research productivity.

What is the ICOHRTA AIDS/TB program?

ICOHRTA AIDS/TB stands for the International Clinical, Operations and Health Services Research Training Award for AIDS and TB. The program is designed to build and sustain research training capacity related to HIV and TB, including training in clinical research as well as operations, health services, and implementation-focused research.

Which NIH organizations are involved in this funding opportunity?

The Funding Opportunity Announcement (FOA) was issued by the Fogarty International Center (FIC) in collaboration with the National Institute of Mental Health (NIMH), the Office of Research on Women's Health (ORWH), and the National Institute on Drug Abuse (NIDA).

Why are institutes like NIMH, ORWH, and NIDA involved?

The collaboration reflects an emphasis that extends beyond biomedical and clinical issues to include behavioral, social, and health systems factors that shape HIV and TB outcomes. This includes areas such as mental health, substance use, and women's health considerations that can influence prevention, care, and treatment results.

What is the main purpose of this award?

The core purpose is to support an integrated training program that measurably strengthens a foreign institution's ability to conduct high-quality clinical research and implementation science related to HIV and TB. The program is intended to develop local expertise and leadership so that research questions, study execution, and translation of findings into real-world health programs are increasingly led within the partner country.

What kinds of research training does the FOA emphasize?

The FOA emphasizes training in clinical research and implementation science, including operations research and health services research focused on HIV infection and TB. Where relevant, it also includes prevention, care, and treatment for HIV/TB coinfection.

What is meant by implementation science in this context?

In this FOA, implementation science refers to learning how to evaluate and improve the delivery of proven interventions in real-world settings such as clinics and community programs. Examples mentioned include improving adherence, retention in care, service integration, and program performance.

What is the funding mechanism for this opportunity?

Funding is provided through the International Training Cooperative Agreement (U2R) mechanism.

What does it mean that this is a cooperative agreement?

As a cooperative agreement, the U2R mechanism generally implies substantial NIH involvement compared to a standard grant. Awardees should expect active programmatic collaboration and oversight consistent with cooperative agreement norms.

How much total funding was estimated to be available?

The total estimated funding available for fiscal year 2009 is $3,000,000.

How many awards were anticipated under this FOA?

The FOA anticipated five to six awards supporting either new Phase II programs or renewals of existing ICOHRTA AIDS/TB Research Training Units.

Is there a maximum budget per award?

Yes. Individual awards have an indicated ceiling of $275,000.

Is future funding guaranteed for multiple years?

No. Future funding levels are contingent on annual appropriations. Multi-year continuity depends on federal budget decisions as well as satisfactory program performance.

Is there a cap on facilities and administrative (F&A) costs?

Yes. Facilities and administrative (F&A) costs are limited to 8% for all awards and subawards.

Why does the FOA include an 8% F&A cap?

The FOA notes this type of restriction is common in certain international training programs and signals NIH's expectation that most of the budget supports programmatic training and research capacity-building activities rather than indirect institutional costs.

When was the FOA posted and what were the key dates?

The FOA was posted on December 2, 2008. The application deadline was August 18, 2009, and the archive date was September 18, 2009. The earliest anticipated start date for awards under this cycle was April 1, 2009.

Who is eligible to submit a new Phase II application?

Eligibility for new Phase II applications is tightly defined. New applications are only accepted from foreign institutions that previously received a Phase I ICOHRTA AIDS/TB planning grant, together with the specific U.S. nonprofit partner institution selected during Phase I.

Does a new Phase II application require an existing Phase I partnership?

Yes. Applicants must already be part of an established Phase I planning partnership and are expected to convert that plan into an operational, comprehensive training program.

Who is eligible to submit a renewal application?

Renewal applications are limited to current ICOHRTA AIDS/TB awardees.

Can a renewal application change the U.S. partner institution?

A change in the U.S. partner institution is possible only if it is strongly justified, according to the FOA.

What are the expectations for the foreign and U.S. partner institutions?

Both the foreign and U.S. partner institutions are expected to demonstrate a strong track record of receiving or being significantly involved in HIV/AIDS and/or TB international research. They must also show clear leadership and capacity to implement the program successfully and maintain long-term productivity.

What is a Research Training Unit in this FOA?

The FOA describes a Research Training Unit as the structure formed by the Phase I foreign awardee and its U.S. partner to deliver the integrated training program under Phase II.

What outcomes is the program designed to achieve?

The program is designed to strengthen a foreign institution's ability to conduct rigorous research (clinical research and implementation/operations/health services studies) and to strengthen the institutional structures needed for sustained research productivity in HIV, TB, and HIV/TB coinfection.

Does the FOA focus only on infectious disease clinical trials?

No. The FOA explicitly reflects a broad view that includes mental health, substance use, women's health considerations, and health system performance, in addition to biomedical and clinical issues, because these factors can strongly influence HIV and TB prevention and treatment outcomes.

What federal program areas are associated with this FOA?

The FOA sits within multiple federal program areas, as reflected by CFDA numbers associated with drug abuse and addiction research, mental health research training, child health and human development extramural research, and international research and research training.

What types of settings does the FOA mention for real-world implementation work?

The FOA points to real-world settings such as clinics and community programs, with attention to practical service-delivery issues like adherence, retention in care, service integration, and program performance.

Who is the primary intended beneficiary of the capacity-building effort?

The primary intended beneficiary is the foreign institution and, more broadly, the partner country, through the development of local expertise and leadership that enables more research to be led locally rather than relying mainly on external investigators.

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