PHS 2010 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42) | Apply Online

Opportunity Summary:

The PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer (STTR) Grant Applications, listed as Funding Opportunity Number PA-10-051, is a broad NIH funding announcement designed to help U.S. small business concerns move promising biomedical and behavioral innovations from early research toward real-world products and services. The core idea behind this opportunity is to fund research and development that aligns with the missions of participating NIH Institutes and Centers, while requiring a formal collaboration between a small business and a U.S. research institution. In practice, it is meant for small companies that have a strong technology concept and need structured, federally supported R and D to prove feasibility, build prototypes, generate key data, and progress toward commercialization in health-related fields.

This announcement uses the STTR grant mechanisms R41 and R42, which cover Phase I, Phase II, and Fast-Track applications. Phase I generally focuses on establishing scientific and technical feasibility and reducing early risks, while Phase II supports further development and more advanced R and D activities that move the project closer to commercialization. The Fast-Track option allows applicants to request Phase I and Phase II support in a single, combined application, which can be useful when a project is ready for a continuous development path without a long gap between phases. Importantly, this STTR solicitation runs in parallel with a separate but scientifically identical SBIR solicitation (PA-10-050) that uses different mechanisms (R43/R44). The distinction matters because STTR, unlike SBIR, is built around a structured small business-research institution partnership, and for this particular opportunity STTR applications are accepted only by NIH. The CDC, FDA, and ACF are specifically noted as not participating in the STTR program under this solicitation.

The scope is intentionally omnibus, meaning it spans a wide range of research topics rather than targeting a single narrow area. Applicants are encouraged to propose projects that fit the research and development priorities of NIH awarding components and to align their proposals with the identified topics referenced in the NIH SBIR/STTR Program Descriptions and Research Topics for PHS 2010-02. The listing of CFDA program areas underscores how broad the scientific coverage is, touching many parts of biomedical, clinical, and public health research. Included areas range from environmental health, oral health, genomics, deafness and communication disorders, complementary and integrative health, mental health, alcohol and drug abuse, and technological innovations for improving human health, to minority health and health disparities, nursing research, and extensive cancer-related categories (prevention, detection, diagnosis, treatment, biology, and control). It also includes major disease and organ-system research portfolios such as cardiovascular, lung, blood, arthritis and musculoskeletal/skin, diabetes and digestive and kidney diseases, neuroscience and neurological disorders, allergy/immunology/transplantation, microbiology and infectious diseases, child health and human development, aging, vision research, and medical library assistance. Taken together, the opportunity is essentially a doorway for small businesses working in nearly any NIH-relevant health technology area, as long as the work is responsive to NIH missions and the STTR requirements are met.

From a funding and award standpoint, NIH emphasizes that awards depend on the availability of funds and the receipt of a sufficient number of high-quality applications. No fixed number of awards or total set-aside amount is guaranteed in the notice; instead, the total amount funded and the number of grants made will vary based on application quality, project duration, and the budgets requested. The opportunity is categorized as discretionary and uses the grant funding instrument. It also explicitly states there is no cost-sharing or matching requirement, which means applicants are not required to provide a mandatory non-federal match as a condition of the award (though companies often still bring additional resources to strengthen commercialization plans).

Eligibility is limited to small businesses, specifically U.S. small business concerns, consistent with STTR program rules. The overall intent is to support companies that not only have innovative R and D ideas, but also have the capability to execute the work and a credible pathway to translate the research into something useful in the health marketplace, whether that is a diagnostic, therapeutic, medical device, digital health tool, research instrument, platform technology, or another product that advances human health.

Key administrative details in the posting include a Posted Date and Creation Date of January 15, 2010, with an Original and Current Closing Date of January 7, 2011, and an Archive Date of February 7, 2011. The primary agency is the National Institutes of Health. The full announcement was made available through the NIH grants guide page at http://grants.nih.gov/grants/guide/pa-files/PA-10-051.html, and technical access or linking issues were directed to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

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Previous opportunity: PHS 2010 02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR R43/R44)

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