PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) | Apply Online

Opportunity Summary:

PHS 2016-02 is an omnibus (multi-agency) Small Business Innovation Research (SBIR) funding opportunity from the U.S. Department of Health and Human Services, bringing together the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), and the Administration for Children and Families (ACF). It is designed to fund U.S. small business concerns that can turn scientific ideas into practical products, services, and technologies that support these agencies research and development missions. The solicitation is a "parent" SBIR announcement using the R43/R44 mechanisms, meaning it supports the standard SBIR pathway that typically starts with early feasibility work (Phase I) and can progress to more advanced development and commercialization-focused work (Phase II), with applicants aligning their proposals to the participating agency component that best matches their topic area.

The opportunity is categorized as discretionary grant funding and spans a wide set of public-purpose areas, including education, environment, food and nutrition, health, and income security and social services. In practice, that breadth reflects how SBIR projects can range from biomedical tools and therapeutics to diagnostics, digital health products, public health technologies, regulatory science innovations relevant to FDA, or interventions and services that improve outcomes for children and families consistent with ACF priorities. Rather than being limited to one narrow research theme, applicants are expected to propose projects that fit within specific topic areas laid out in the companion document, "PHS 2016-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, FDA, and ACF." That topic list is central to determining fit, because it tells small businesses exactly what kinds of innovations each participating component is seeking.

Eligibility is restricted to U.S. small business concerns, meaning the applicant organization must meet SBIR size and ownership requirements and must be positioned to perform the proposed research and development work. The announcement encourages companies that already have relevant research capabilities and technical expertise to apply, especially those that can clearly connect their technology to an agency mission need and show a credible path from R and D to real-world use. While the notice does not list an award ceiling or expected number of awards in the provided data, the SBIR structure generally emphasizes milestone-driven R and D, clear deliverables, and commercialization potential, so competitive applications typically explain the technical innovation, feasibility, development plan, and how the result could ultimately be deployed in clinical, public health, regulatory, or human services settings.

Administratively, the funding opportunity number is PA-16-302, and it was posted and created on June 3, 2016. The closing date listed is April 5, 2017. It is associated with a large set of CFDA program numbers (93.xxx series), reflecting the many HHS programs and institutes that can make awards under this umbrella solicitation. Overall, the intent of PHS 2016-02 is to provide a streamlined entry point for small businesses to compete for federal R and D support across multiple HHS agencies, as long as the proposed innovation matches one of the identified SBIR topic areas and advances the mission of the targeted awarding component.

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