Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21) | Apply Online

Opportunity Summary:

The Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21) opportunity (Funding Opportunity Number PA 09 133) is a National Institutes of Health discretionary grant program led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in partnership with the NIH Office of Dietary Supplements (ODS). Its main goal is to support early stage, exploratory clinical research that could meaningfully improve how diabetes, obesity, endocrine disorders, and genetic metabolic diseases are prevented or treated. The focus is on short term clinical studies that let investigators test fresh ideas quickly, without the heavy expectation of extensive preliminary data that is typical for larger clinical trials and later stage awards. In practical terms, this funding is meant to help researchers find out whether a new clinical concept is workable and promising enough to justify bigger, more definitive studies later on.

A central theme of the program is “pilot and feasibility” work: small, carefully designed clinical projects that answer high impact questions and reduce uncertainty. The announcement specifically highlights studies that test new prevention strategies, new interventions, or novel combinations of therapies. Another major priority is translation, meaning the program is particularly interested in helping move strong laboratory or preclinical discoveries into real world clinical testing. The scope explicitly spans diabetes and endocrine diseases as well as genetic metabolic diseases, and it also notes cystic fibrosis within that broader set of conditions, reflecting the program’s interest in metabolic and endocrine complications across disease areas.

The mechanism used is the NIH Exploratory/Developmental grant mechanism (R21). R21 awards are generally structured to fund early, concept testing work rather than large scale validation, which fits the stated goal of enabling short, targeted clinical studies. The notice lists an award ceiling of $200,000, signaling that projects should be scoped accordingly, with realistic milestones that can be achieved within an exploratory budget. At the same time, the announcement makes clear that the exact size, duration, total dollars awarded, and number of awards are not fixed in advance. Instead, those outcomes depend on the volume of applications received and, most importantly, the quality, cost, and proposed duration of the applications that are submitted and deemed meritorious.

Eligibility is broad and includes many types of domestic and non domestic organizations. Eligible applicants include public and state controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for profit organizations (including small businesses and other than small businesses), and a wide range of governmental entities such as state, county, city or township governments, special district governments, and independent school districts. The program also welcomes applications from Native American tribal governments (both federally recognized and other than federally recognized) and tribal organizations, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), faith based or community based organizations, regional organizations, U.S. territories or possessions, and even foreign organizations (non U.S. entities). The listing also notes that eligible agencies of the federal government may apply. There is no cost sharing or matching requirement, which lowers the barrier to participation for organizations that may not have discretionary funds to contribute.

In terms of administrative details, the opportunity falls under the “Food and Nutrition” and “Health” activity categories and is associated with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The announcement was posted and created on March 17, 2009, with an original closing date of May 7, 2012 and the same current closing date listed, after which it was archived on June 7, 2012. While it is an archived opportunity and not an active application window today, the summary still reflects the program’s intent: to provide a relatively fast, flexible funding path for early clinical testing that could open the door to larger clinical trials and, ultimately, changes in clinical practice for diabetes, obesity, and endocrine and metabolic diseases.

For applicants or readers who need the full text, the announcement points to the NIH Grants Guide link (http://grants.nih.gov/grants/guide/pa-files/PA-09-133.html). For technical access issues, it directs inquiries to the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV.

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