Opportunity Information: Apply for PAR 12 279

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pilot Intervention and Services Research Grants (R34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs.
  • This funding opportunity was created on Feb 24, 2014 and posted on Sep 7, 2012.
  • Applicants must submit their applications by May 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $225,000.00 in funding.
  • Eligible applicants include: City or township governments Special district governments County governments Independent school districts Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Native American tribal governments (Federally recognized) Small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Pilot Intervention and Services Research Grants (R34) opportunity (Funding Opportunity Number PAR-12-279) is a National Institutes of Health discretionary grant program designed to support early-stage, preparatory research that helps move promising mental health and alcohol-related interventions and service approaches toward larger, definitive studies. The core idea of this FOA is to fund the kinds of development work and pilot testing that are typically needed before an investigator is truly ready to launch a full-scale efficacy or effectiveness trial. In practice, this means the program is focused on generating the practical, real-world evidence and refinement needed to justify and design a subsequent, larger intervention or services study.

The FOA specifically encourages three broad types of projects. First, it supports the development and/or pilot testing of brand-new interventions or meaningful adaptations of existing interventions. Second, it supports adapting and/or pilot testing interventions that already have demonstrated efficacy, with the goal of preparing them for broader-scale effectiveness trials in more routine, real-world settings or with more diverse populations. Third, it invites innovative services research directions that are still too early for a large study and therefore require preliminary development or testing to demonstrate that the approach is workable and worth scaling.

A defining feature of the R34 mechanism under this announcement is its emphasis on feasibility-oriented outcomes rather than definitive clinical endpoints. Applicants are expected to use R34 funds to evaluate whether the approach can be delivered as intended and whether it is practical in the targeted setting and population. The FOA highlights feasibility, tolerability, acceptability, and safety as central targets of evaluation, along with the collection of preliminary data that can serve as the foundation for a later, larger trial. This can include work like refining intervention content and delivery, testing recruitment and retention strategies, confirming adherence and fidelity procedures, piloting outcome measures, and establishing whether an implementation approach is workable within the constraints of real service systems.

The scientific scope aligns with the missions of the participating NIH institutes referenced in the announcement. For the National Institute of Mental Health (NIMH), the focus is on intervention and services research aimed at preventing or reducing mental disorders and emotional or behavioral problems, including situations where mental health issues co-occur with physical health conditions, substance use problems, or HIV infection, and where these conditions produce functional impairments across the lifespan. For the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the emphasis is on prevention, treatment, and services research related to alcohol use disorders and associated emotional or behavioral problems, again including co-occurring mental, physical, and other substance use problems, HIV/AIDS, and the functional consequences of these conditions across the lifespan. In other words, the announcement is broad in population and setting, but it is tightly focused on pilot-stage intervention and services work that can credibly lead to a subsequent larger study.

From an administrative standpoint, this is a grant funding opportunity in the health activity category, tied to CFDA numbers 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs). It does not require cost sharing or matching. The award ceiling listed is $225,000. The opportunity was posted September 7, 2012, with an original closing date of September 7, 2015, and it later shows a current closing date of May 7, 2014, with an archive date of June 7, 2014, indicating the listing is now archived rather than open for new submissions under those dates.

Eligibility is intentionally broad and includes many types of domestic and non-domestic applicants. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public housing authorities and Indian housing authorities. A wide range of organizational types may apply, including small businesses, for-profit organizations other than small businesses, private institutions of higher education, and public or state-controlled institutions of higher education. Nonprofits are eligible whether or not they have 501(c)(3) status (with the typical exception language for institutions of higher education), and tribal entities are included both as federally recognized tribal governments and as tribal organizations that are not federally recognized. The eligibility list also calls out a variety of mission-specific institution types such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions. Faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies are also listed. Importantly, foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, which signals openness to international collaboration and study settings where justified.

For applicants looking for the official announcement and detailed application requirements, the FOA points to the NIH grants page at http://grants.nih.gov/grants/guide/pa-files/PAR-12-279.html. The contact provided for technical access or linking issues is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs): Pilot Intervention and Services Research Grants (R34) - PAR-12-279

1. What is PAR-12-279 (Pilot Intervention and Services Research Grants - R34)?

PAR-12-279 is a National Institutes of Health (NIH) discretionary grant opportunity that uses the R34 mechanism to support early-stage, preparatory research. Its purpose is to help investigators develop, refine, and pilot test mental health and alcohol-related interventions and service approaches so they are ready for a later, larger, more definitive study.

2. What is the main goal of this R34 funding opportunity?

The main goal is to fund the development work and pilot testing that typically needs to happen before launching a full-scale efficacy or effectiveness trial. The emphasis is on generating practical evidence and refinement that can justify and inform the design of a subsequent larger intervention or services study.

3. What types of projects are encouraged under this FOA?

The FOA encourages three broad project types: (1) development and/or pilot testing of brand-new interventions or meaningful adaptations of existing interventions; (2) adapting and/or pilot testing interventions with demonstrated efficacy to prepare them for broader effectiveness trials in more routine, real-world settings or with more diverse populations; and (3) innovative services research approaches that are not yet ready for a large study and therefore require preliminary development or testing to show they are workable and worth scaling.

4. Is this program meant to fund large, definitive clinical trials?

No. A defining feature of this R34 program is that it is geared toward feasibility-focused, preparatory research rather than definitive clinical endpoints. The intent is to position a project for a later, larger trial by doing the necessary pilot-stage work first.

5. What outcomes does the FOA emphasize for R34 projects?

The FOA emphasizes feasibility-oriented outcomes rather than definitive clinical endpoints. Central evaluation targets include feasibility, tolerability, acceptability, and safety, along with collection of preliminary data that can serve as the foundation for a later, larger trial.

6. What kinds of activities can R34 funds support?

Examples of activities described in the FOA include refining intervention content and delivery, testing recruitment and retention strategies, confirming adherence and fidelity procedures, piloting outcome measures, and determining whether an implementation approach is workable within real service system constraints.

7. What research areas does this opportunity cover?

The scientific scope aligns with the missions of participating NIH institutes referenced in the announcement. It covers pilot-stage intervention and services research in mental health and alcohol-related domains, including prevention, treatment, and services research, with attention to functional impairments across the lifespan and co-occurring conditions.

8. How does the FOA define the mental health scope (NIMH-related)?

For the National Institute of Mental Health (NIMH), the scope includes intervention and services research aimed at preventing or reducing mental disorders and emotional or behavioral problems. It includes circumstances where mental health issues co-occur with physical health conditions, substance use problems, or HIV infection, and where these conditions lead to functional impairments across the lifespan.

9. How does the FOA define the alcohol-related scope (NIAAA-related)?

For the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the scope includes prevention, treatment, and services research related to alcohol use disorders and associated emotional or behavioral problems. It also includes co-occurring mental and physical conditions, other substance use problems, HIV/AIDS, and functional consequences across the lifespan.

10. Is the opportunity limited to certain populations or settings?

The announcement is broad in population and setting, but it is tightly focused on pilot-stage intervention and services work that can credibly lead to a subsequent larger study.

11. What is the funding activity category for this opportunity?

This opportunity is listed under the health activity category.

12. What CFDA numbers are associated with this grant opportunity?

The FOA is tied to CFDA numbers 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs).

13. Is cost sharing or matching required?

No. The listing states that it does not require cost sharing or matching.

14. What is the award ceiling for this opportunity?

The award ceiling listed is $225,000.

15. When was this opportunity posted, and what are the listed closing dates?

The opportunity was posted on September 7, 2012. It lists an original closing date of September 7, 2015, and it also shows a current closing date of May 7, 2014, with an archive date of June 7, 2014.

16. Is this funding opportunity currently open for new submissions?

Based on the dates provided, the listing indicates it is archived rather than open for new submissions under those dates (archive date: June 7, 2014).

17. Who is eligible to apply?

Eligibility is intentionally broad and includes many types of domestic and non-domestic applicants. Eligible applicants include various U.S. government entities (state, county, city or township), special district governments, independent school districts, public housing authorities, and Indian housing authorities, as well as a wide range of organizational types in the nonprofit, for-profit, and higher education sectors.

18. Are small businesses and for-profit organizations eligible?

Yes. The eligibility list includes small businesses and for-profit organizations other than small businesses.

19. Are colleges and universities eligible?

Yes. Both private institutions of higher education and public/state-controlled institutions of higher education are eligible.

20. Are nonprofit organizations eligible, including those without 501(c)(3) status?

Yes. Nonprofits are eligible whether or not they have 501(c)(3) status (with the typical exception language for institutions of higher education noted in the listing).

21. Are tribal entities eligible?

Yes. The eligibility list includes federally recognized tribal governments and tribal organizations that are not federally recognized.

22. Are mission-specific institution types explicitly included (e.g., HBCUs, HSIs)?

Yes. The list specifically calls out institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions (HSIs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions.

23. Are faith-based and community-based organizations eligible?

Yes. Faith-based and community-based organizations are explicitly listed as eligible.

24. Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed among eligible applicants.

25. Are federal agencies eligible to apply?

Yes. Eligible federal agencies are listed as eligible applicants.

26. Can foreign institutions apply?

Yes. The eligibility information states that foreign institutions may apply.

27. Are non-U.S. components of U.S. organizations eligible?

Yes. Non-U.S. components of U.S. organizations are listed as eligible.

28. Are foreign components allowed as part of an application?

Yes. Foreign components are allowed as defined by NIH policy, signaling that international collaboration and study settings may be included where justified.

29. Where can applicants find the official NIH announcement and application requirements?

The FOA points to the NIH grants page at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-279.html

30. Who is the contact for technical access or linking issues related to the FOA webpage?

The contact provided is the NIH Office of Extramural Research webmaster: FBOWebmaster@OD.NIH.GOV

31. What is the overall theme of what reviewers or the FOA wants to see at the R34 stage?

Based on the description provided, the R34 stage is about demonstrating that an intervention or service approach is practical and can be delivered as intended in the target setting and population, and about generating preliminary evidence (including feasibility, acceptability, tolerability, safety, and operational procedures) that supports moving to a later, larger study.

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