Opportunity Information: Apply for RFA HG 12 010
Apply for RFA HG 12 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Study Investigators (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jun 20, 2012 and posted on Jun 20, 2012.
- Applicants must submit their applications by Oct 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,100,000.00 in funding.
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses City or township governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Independent school districts County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Study Investigators (U01) is a National Institutes of Health funding opportunity (RFA-HG-12-010) focused on expanding genomic research beyond primarily European-ancestry populations. The central goal is to support investigators who can sample and measure genomic variation in well-characterized, well-phenotyped individuals of non-European ancestry, and then broadly disseminate the resulting data so it becomes a widely usable population resource. In practical terms, the program is designed to strengthen what is known about how genetic risk factors for disease may differ across ancestral backgrounds, and to improve the ability of researchers to discover and interpret genomic associations in diverse populations rather than treating findings from European-ancestry datasets as universally applicable.
This opportunity represents a second phase that builds directly on the earlier PAGE I effort, but scales up both the density and the scope of genomic assays. Over a four-year project period, awardees are expected to generate large-scale, dense genomic data that capture both common and rare variation, with particular emphasis on coding regions and/or other variants likely to be functional (meaning plausibly relevant to biological mechanisms and disease). A key requirement embedded in the description is that the participants already have extensive phenotype information available. That implies that the intended studies are not simply about collecting DNA; they are about pairing high-resolution genomic measures with rich clinical, epidemiologic, or trait data to enable robust association analyses and cross-population comparisons.
The funding mechanism is a U01 cooperative agreement, which signals a substantial level of NIH program involvement compared with a standard research project grant. Cooperative agreements commonly require close coordination with NIH staff and other awardees, alignment with shared program goals, and adherence to program-wide expectations for data generation, harmonization, quality control, and sharing. For PAGE Phase II, that cooperative structure fits the stated aim of creating a community resource: the value of the program increases when multiple study sites generate comparable datasets that can be combined or compared, and when the resulting information is made accessible for broader use.
Financially, the announcement lists an estimated total funding amount of $4,200,000, with an award ceiling of $1,100,000. There is no cost sharing or matching requirement. The opportunity was posted on June 20, 2012, with an original and current closing date of October 18, 2012, and an archive date of November 18, 2012, indicating the competition is historical rather than currently open. The activity category is Health, and the CFDA number is 93.172 (Human Genome Research), reflecting the genomics emphasis and alignment with NIH genome research priorities.
Eligibility is broad and includes many U.S.-based organization types and government entities, such as state and local governments, public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses), public housing authorities/Indian housing authorities, independent school districts, special district governments, and tribal governments and organizations. The announcement also explicitly notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions and other non-U.S. entities are not eligible to apply, but non-U.S. components of U.S. organizations may participate, and foreign components (as defined by NIH policy) are allowed, which typically means international activities can be included when justified and structured under NIH’s foreign component rules.
Taken together, the opportunity is essentially a targeted investment in building high-value, shareable genomic datasets for non-European ancestry groups, leveraging existing cohorts with deep phenotype data, and producing dense variant information that includes both common and rare (often more informative) variants. The broader purpose is to improve discovery, interpretation, and ultimately translation of genomic associations across diverse ancestral backgrounds, addressing a major limitation in human genomics where risk prediction, variant interpretation, and disease biology have historically been skewed toward European-ancestry reference data.
Frequently Asked Questions (FAQs)
What is the title and identifier of this funding opportunity?
The opportunity is titled Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Study Investigators (U01). The NIH funding opportunity number is RFA-HG-12-010.
Who is sponsoring this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What is the main purpose of PAGE Phase II?
The central purpose is to expand genomic research beyond primarily European-ancestry populations by supporting investigators who can measure dense genomic variation in well-characterized individuals of non-European ancestry, paired with extensive phenotype information, and then broadly disseminate the resulting data as a widely usable population resource.
Why does this opportunity emphasize non-European ancestry populations?
The program is designed to strengthen understanding of how genetic risk factors for disease may differ across ancestral backgrounds and to improve discovery and interpretation of genomic associations in diverse populations, rather than assuming results from European-ancestry datasets apply universally.
What does "Phase II" mean in the context of PAGE?
PAGE Phase II is described as a second phase that builds directly on the earlier PAGE I effort, while scaling up both the density and the scope of genomic assays conducted over the project period.
What type of grant mechanism is used?
The funding mechanism is a U01 cooperative agreement.
What does a U01 cooperative agreement imply for awardees?
A U01 cooperative agreement indicates substantial NIH program involvement compared with a standard research project grant. It commonly involves close coordination with NIH staff and other awardees, alignment with shared program goals, and adherence to program-wide expectations for data generation, harmonization, quality control, and data sharing.
What kinds of data are awardees expected to generate?
Over a four-year project period, awardees are expected to generate large-scale, dense genomic data capturing both common and rare variation, with particular emphasis on coding regions and/or other variants likely to be functional (plausibly relevant to biological mechanisms and disease).
Is this opportunity focused on collecting new DNA samples?
The description emphasizes that participants already have extensive phenotype information available. This implies the studies are not simply about collecting DNA; they are about pairing high-resolution genomic measures with rich clinical, epidemiologic, or trait data to enable robust association analyses and cross-population comparisons.
What does "well-phenotyped" mean here?
Based on the description provided, "well-phenotyped" refers to individuals for whom extensive phenotype information is already available, such as clinical, epidemiologic, or trait measures that can be analyzed alongside dense genomic data.
What is meant by "functional" variants in this announcement?
The announcement describes functional variants as those that are plausibly relevant to biological mechanisms and disease, with particular emphasis on variants in coding regions and/or other variants likely to have functional impact.
How long is the project period?
The described project period is four years.
What is the overall funding amount and the maximum award size?
The announcement lists an estimated total funding amount of $4,200,000 and an award ceiling of $1,100,000.
Is cost sharing or matching required?
No. The opportunity specifies no cost sharing or matching requirement.
What is the activity category for this opportunity?
The activity category is Health.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.172, identified as Human Genome Research.
When was this opportunity posted and when did it close?
It was posted on June 20, 2012. The original and current closing date is October 18, 2012. The archive date is November 18, 2012.
Is this funding opportunity currently open?
No. The provided dates (closing date in 2012 and an archive date in 2012) indicate the competition is historical rather than currently open.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organization types and government entities, including:
- State and local governments
- Public and private institutions of higher education
- Nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits)
- For-profit organizations (including small businesses)
- Public housing authorities/Indian housing authorities
- Independent school districts
- Special district governments
- Tribal governments and tribal organizations
Are specific institution types explicitly noted as eligible?
Yes. The announcement explicitly notes additional eligible applicants such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
- Eligible federal agencies
Are foreign institutions eligible to apply?
No. Foreign institutions and other non-U.S. entities are not eligible to apply based on the information provided.
Can international activities be included in a project?
Yes, in limited ways as described: non-U.S. components of U.S. organizations may participate, and foreign components (as defined by NIH policy) are allowed. This typically means international activities can be included when justified and structured under NIH foreign component rules.
What is the program expecting in terms of data sharing?
A key goal is broad dissemination of the resulting genomic data so it becomes a widely usable population resource. The cooperative structure also reflects expectations for data harmonization, quality control, and sharing across awardees.
How does the cooperative structure support the program goals?
The program’s value increases when multiple study sites generate comparable datasets that can be combined or compared, and when resulting information is made accessible for broader use. The U01 structure supports coordination toward these shared goals.
What is the broader impact the program is trying to achieve?
The broader purpose is to improve discovery, interpretation, and eventual translation of genomic associations across diverse ancestral backgrounds, addressing a major limitation in human genomics where risk prediction, variant interpretation, and disease biology have been skewed toward European-ancestry reference data.
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