Opportunity Information: Apply for RFA HG 12 015
Apply for RFA HG 12 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Population Architecture Using Genomics and Epidemiology (PAGE), Phase II Coordinating Center (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jun 20, 2012 and posted on Jun 20, 2012.
- Applicants must submit their applications by Oct 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Private institutions of higher education State governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH funding opportunity (RFA-HG-12-015) supports a single, centralized Coordinating Center for Phase II of the Population Architecture Using Genomics and Epidemiology (PAGE) program. It is a cooperative agreement (U01), meaning the awardee would not only receive funding but would also work closely with NIH and the participating PAGE study sites under a more hands-on, collaborative federal role than a typical research grant. The overall goal is to provide the operational backbone for the PAGE Phase II consortium so that multiple funded studies can function as a unified program rather than as disconnected projects.
The PAGE Phase II scientific focus is on improving the evidence base for genetic associations in populations that have historically been underrepresented in genomics, specifically individuals of non-European ancestry. The underlying problem PAGE is addressing is that many genomic disease-association findings and reference resources were built primarily from European-ancestry cohorts, which can limit discovery, reduce accuracy of risk estimates in other groups, and slow progress toward equitable genomic medicine. PAGE Phase II builds on lessons from PAGE I and expands the scale and density of genomic assays, including large-scale genotyping and/or sequencing approaches that capture both common variation and rarer coding or potentially functional variants. Importantly, PAGE emphasizes using participants who are already well phenotyped, meaning they have extensive existing clinical, epidemiologic, and trait data that can be linked to newly generated genomic data for association testing and cross-study analyses.
Within that context, the Coordinating Center is intended to serve as the hub for consortium-wide coordination and support. In practical terms, this typically includes organizing governance and communication across sites, running working groups, scheduling meetings, maintaining documentation, tracking milestones, harmonizing policies, and ensuring that consortium decisions are implemented consistently. Because PAGE Phase II involves multiple investigators and studies generating large genomic datasets tied to rich phenotype information, the Coordinating Center would also be expected to play a key role in data management planning and cross-study harmonization. That can include helping establish common data dictionaries, phenotype harmonization strategies, consistent quality control expectations, and procedures for combining data across cohorts so that pooled analyses are scientifically defensible and reproducible. A major deliverable embedded in the announcement is dissemination of resulting data to create a broadly useful population resource; the Coordinating Center therefore functions as a facilitator for data sharing, ensuring that datasets and associated documentation are prepared for deposition and use by the wider research community in accordance with NIH policies, participant consent limitations, and applicable privacy protections.
The program period is four years, and NIH anticipated making one award, with an estimated total funding level of up to $800,000 and an award ceiling of $800,000. There is no cost sharing or matching requirement. The opportunity was posted June 20, 2012, with an original and current closing date of October 18, 2012, and an archive date of November 18, 2012. The administering agency is the National Institutes of Health, and the relevant CFDA number listed is 93.172 (Human Genome Research).
Eligibility is broad and includes many types of U.S.-based organizations and governmental units, such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities, school districts, and special district governments. The announcement explicitly notes additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions and other non-U.S. entities are not eligible to apply, although non-domestic components of U.S. organizations may be eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement.
Overall, the opportunity is best understood as infrastructure funding for a genomics consortium focused on non-European ancestry populations: the Coordinating Center is responsible for keeping PAGE Phase II coordinated, standardized, and productive, while enabling high-quality data generation, harmonization, and dissemination so the resulting resource can meaningfully expand knowledge about ancestry-related differences in genomic associations with disease and other traits. For full details, NIH provided the archived announcement link: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-12-015.html.
Frequently Asked Questions (FAQs): NIH RFA-HG-12-015 (PAGE Phase II Coordinating Center, U01)
1) What is this funding opportunity?
This is an NIH funding opportunity announcement (RFA-HG-12-015) to support a single, centralized Coordinating Center for Phase II of the Population Architecture Using Genomics and Epidemiology (PAGE) program.
2) What activity code and award mechanism does it use?
The award mechanism is a cooperative agreement (U01). Under a U01, the awardee receives funding and also works closely with NIH and participating PAGE study sites under a more hands-on, collaborative federal role than a typical research grant.
3) How many awards does NIH expect to make?
NIH anticipated making one award.
4) What is the program period (project duration)?
The program period is four years.
5) How much funding is available and what is the budget ceiling?
The estimated total funding level is up to $800,000, and the award ceiling is $800,000.
6) Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
7) What is the main purpose of the Coordinating Center?
The Coordinating Center is intended to provide the operational backbone for PAGE Phase II so that multiple funded studies function as a unified consortium rather than as disconnected projects.
8) What kinds of responsibilities are typically expected of the Coordinating Center?
Based on the announcement description, typical responsibilities include consortium-wide governance and communication support, organizing working groups, scheduling meetings, maintaining documentation, tracking milestones, harmonizing policies, and ensuring consortium decisions are implemented consistently across sites.
9) How does the Coordinating Center support data-related activities across the consortium?
Because PAGE Phase II involves multiple studies generating large genomic datasets linked to rich phenotype information, the Coordinating Center is expected to play a key role in data management planning and cross-study harmonization. This can include helping establish common data dictionaries, phenotype harmonization strategies, consistent quality control expectations, and procedures for combining data across cohorts for pooled analyses.
10) What is the scientific focus of PAGE Phase II?
PAGE Phase II focuses on improving the evidence base for genetic associations in populations that have historically been underrepresented in genomics, specifically individuals of non-European ancestry.
11) Why is PAGE Phase II focusing on non-European ancestry populations?
The opportunity describes a key problem PAGE is addressing: many genomic disease-association findings and reference resources were built primarily from European-ancestry cohorts. This can limit discovery, reduce accuracy of risk estimates in other groups, and slow progress toward more equitable genomic medicine.
12) What type of genomic data generation is emphasized in PAGE Phase II?
PAGE Phase II expands the scale and density of genomic assays, including large-scale genotyping and/or sequencing approaches that capture both common variation and rarer coding or potentially functional variants.
13) What does it mean that PAGE uses “well phenotyped†participants?
It means participants already have extensive existing clinical, epidemiologic, and trait data. PAGE Phase II links that existing phenotype information to newly generated genomic data to support association testing and cross-study analyses.
14) What is expected regarding data sharing and dissemination?
A major deliverable is dissemination of resulting data to create a broadly useful population resource. The Coordinating Center serves as a facilitator for data sharing by helping ensure datasets and documentation are prepared for deposition and broader research use in accordance with NIH policies, participant consent limitations, and applicable privacy protections.
15) Who is the administering agency?
The administering agency is the National Institutes of Health (NIH).
16) What CFDA number is associated with this opportunity?
The CFDA number listed is 93.172 (Human Genome Research).
17) When was this opportunity posted, and what were the key dates?
It was posted on June 20, 2012. The original and current closing date is October 18, 2012, and the archive date is November 18, 2012.
18) Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types and governmental units, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities, school districts, and special district governments.
19) Are specific institution types explicitly called out as eligible?
Yes. The announcement explicitly notes additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
20) Are foreign institutions eligible to apply?
No. Foreign institutions and other non-U.S. entities are not eligible to apply.
21) Are any foreign or non-U.S. components allowed in the project?
Yes. The announcement notes that non-domestic components of U.S. organizations may be eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement.
22) Is this opportunity mainly for research, infrastructure, or both?
Based on the description provided, the opportunity is best understood as infrastructure funding for a genomics consortium. The Coordinating Center’s primary role is to keep PAGE Phase II coordinated, standardized, and productive while enabling high-quality data generation, harmonization, and dissemination across the consortium.
23) Where can applicants find the full archived announcement?
The archived announcement link provided by NIH is: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-12-015.html.
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