Opportunity Information: Apply for PA 16 146
Apply for PA 16 146
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Population Health Interventions: Integrating Individual and Group Level Evidence (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.273, 93.279, 93.399,.
- This funding opportunity was created on Mar 22, 2016 and posted on Mar 22, 2016.
- Applicants must submit their applications by May 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
Population Health Interventions: Integrating Individual and Group Level Evidence (R01) (Funding Opportunity Number PA 16-146) is a National Institutes of Health (NIH) research grant opportunity administered under HHS-NIH11. The core aim is to push health research beyond strictly biological and clinical approaches by supporting studies that work at the population level, where real-world conditions shape health outcomes. In practical terms, the opportunity is designed for intervention research that can improve health and reduce disease burden by addressing not only individual behavior or treatment, but also the larger social, economic, and environmental factors that influence health across communities and groups.
A defining feature of this FOA is its emphasis on multilevel and transdisciplinary population health interventions. "Multilevel" implies that proposed interventions should consider and, where appropriate, act across more than one layer of influence, such as individuals, families, schools, workplaces, neighborhoods, local systems, and policies. "Transdisciplinary" signals that applicants are expected to integrate perspectives, methods, and evidence from multiple fields, which might include public health, medicine, behavioral science, sociology, economics, education, environmental science, implementation science, and related disciplines. The intention is to support research that connects individual-level evidence (such as clinical outcomes, behavior change mechanisms, or patient-level risk factors) with group- or community-level evidence (such as community conditions, institutional practices, resource distribution, or policy environments) in order to produce measurable improvements in health outcomes.
The intervention focus is specifically described as targeting underlying social, economic, and environmental conditions. That framing highlights upstream determinants of health, meaning the structural and contextual drivers that often explain why certain populations experience higher disease rates or worse outcomes. Projects responsive to this FOA would typically be those that attempt to change conditions that shape health at scale, for example by modifying environments, improving access to resources, shifting institutional practices, or addressing barriers that arise from socioeconomic disadvantage. While the FOA description provided does not list specific disease areas, it is positioned broadly around improving health outcomes and reducing disease burden, which allows for a wide range of population health topics as long as the approach is intervention-oriented and grounded in integrated evidence across levels.
This opportunity uses the NIH R01 funding mechanism, which is a standard research project grant intended to support discrete, specified research projects. The program is categorized as discretionary and falls under the funding activity areas of education and health. The listing includes multiple CFDA numbers (93.121, 93.273, 93.279, 93.399), reflecting that NIH activity can span multiple institutes, centers, or program areas associated with those assistance listings. The FOA was created and posted on March 22, 2016, with an original and current closing date of May 7, 2019. The source data provided does not specify an award ceiling or the expected number of awards.
Eligibility is broad and includes many types of organizations that commonly conduct or partner on public health and intervention research. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as described in NIH eligibility clarifications. This wide eligibility reflects the real-world nature of population health intervention work, which often involves partnerships among universities, health systems, schools, housing organizations, community groups, and government agencies.
Overall, the opportunity is best understood as NIH support for research that tests and refines intervention strategies capable of improving health at scale by working across levels of influence. The emphasis is on implementing scientific research in ways that meaningfully reach populations and communities, especially by addressing upstream conditions that shape health outcomes, rather than limiting research to individual-level or clinical-only solutions.
FAQs: Population Health Interventions: Integrating Individual and Group Level Evidence (R01) (PA 16-146)
What is the title and funding opportunity number of this grant?
The opportunity is titled "Population Health Interventions: Integrating Individual and Group Level Evidence (R01)" and the Funding Opportunity Number is PA 16-146.
Which agency administers this funding opportunity?
This is a National Institutes of Health (NIH) research grant opportunity administered under HHS-NIH11.
What is the main purpose of this FOA?
The core purpose is to support research that improves health and reduces disease burden by moving beyond strictly biological and clinical approaches and testing intervention strategies at the population level under real-world conditions.
What kind of research does this opportunity support?
It supports intervention research that integrates individual-level evidence (for example, clinical outcomes or behavior change mechanisms) with group- or community-level evidence (for example, community conditions, institutional practices, resource distribution, or policy environments) to produce measurable improvements in health outcomes.
What does "population level" mean in the context of this FOA?
In this FOA, population level refers to research that accounts for real-world social, economic, and environmental conditions that shape health outcomes across communities and groups, rather than focusing only on individual patients or clinical settings.
What does "multilevel" mean for proposed interventions?
"Multilevel" means interventions should consider and, when appropriate, act across more than one layer of influence, such as individuals, families, schools, workplaces, neighborhoods, local systems, and policies.
What does "transdisciplinary" mean for applicants?
"Transdisciplinary" indicates applicants are expected to integrate perspectives, methods, and evidence from multiple fields. Examples mentioned include public health, medicine, behavioral science, sociology, economics, education, environmental science, implementation science, and related disciplines.
What types of factors should the interventions target?
The intervention focus is described as targeting underlying social, economic, and environmental conditions. This points to upstream determinants of health, meaning structural and contextual drivers that can influence disease rates and health outcomes across populations.
Does the FOA specify particular diseases or health conditions?
The description provided does not list specific disease areas. It is positioned broadly around improving health outcomes and reducing disease burden, as long as the project is intervention-oriented and integrates evidence across individual and group levels.
What is the funding mechanism used for this opportunity?
This opportunity uses the NIH R01 mechanism, a standard research project grant intended to support discrete, specified research projects.
How is this program categorized?
The program is categorized as discretionary and falls under the funding activity areas of education and health.
Which CFDA numbers are associated with this opportunity?
The listing includes CFDA numbers 93.121, 93.273, 93.279, and 93.399.
When was this FOA created and posted?
The FOA was created and posted on March 22, 2016.
What is the application closing date?
The original and current closing date listed is May 7, 2019.
Is an award ceiling provided?
The source information provided does not specify an award ceiling.
Does the listing state how many awards NIH expects to make?
No. The source information provided does not specify the expected number of awards.
Who is eligible to apply?
Eligibility is broad and includes: state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with 501(c)(3) status (excluding higher education institutions in that nonprofit category); nonprofit organizations without 501(c)(3) status (excluding higher education institutions in that nonprofit category); for-profit organizations other than small businesses; small businesses; and other entities as described in NIH eligibility clarifications.
Are for-profit organizations allowed to apply?
Yes. The eligibility list includes for-profit organizations other than small businesses as well as small businesses.
Are tribal entities eligible?
Yes. Federally recognized Native American tribal governments are eligible, and Native American tribal organizations other than federally recognized tribal governments are also eligible.
Are schools and education entities eligible?
Yes. Independent school districts are eligible, and the funding activity areas include education and health.
Are housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are included in the eligible applicant types.
What kinds of partnerships fit the intent of this FOA?
The description emphasizes real-world population health intervention work, which often involves partnerships among universities, health systems, schools, housing organizations, community groups, and government agencies.
What is a defining feature of this FOA compared to individual-only interventions?
A defining feature is the emphasis on multilevel, transdisciplinary interventions that link individual-level evidence with group- or community-level evidence, with a specific focus on upstream social, economic, and environmental conditions that shape health at scale.
What does "upstream determinants of health" refer to here?
It refers to structural and contextual drivers that influence health outcomes, including social conditions, economic circumstances, and environmental contexts that can contribute to higher disease rates or worse outcomes in certain populations.
What outcomes is the FOA aiming to influence?
The FOA is broadly aimed at producing measurable improvements in health outcomes and reducing disease burden through interventions that operate across levels of influence.
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