Opportunity Information: Apply for RFA PM 16 001

  • The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Precision Medicine Initiative Cohort Program Coordinating Center (U2C)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310,.
  • This funding opportunity was created on Nov 16, 2015 and posted on Nov 16, 2015.
  • Applicants must submit their applications by Feb 17, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for RFA PM 16 001

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Opportunity Summary:

The Precision Medicine Initiative Cohort Program Coordinating Center (U2C) funding opportunity (RFA-PM-16-001) is a National Institutes of Health (NIH) cooperative agreement intended to stand up and operate a single, central Coordinating Center for the Precision Medicine Initiative (PMI) Cohort Program. The core purpose is to support the infrastructure and day-to-day coordination needed to build and sustain a very large national research cohort, with an ultimate target of one million or more volunteers across the United States. A defining feature of the program is that participants are meant to be actively engaged as partners, not just passive study subjects, in a long-term, longitudinal effort designed to improve how researchers understand why individuals experience health and disease differently.

This opportunity sits in the health funding activity area and is administered under HHS/NIH (listed as HHS-NIH11), with CFDA numbers 93.310 (and also associated with 93.310 in the source listing). The funding mechanism is a cooperative agreement, which generally signals substantial federal involvement in the project’s direction and oversight compared with a standard grant. In practical terms, that structure fits a national-scale cohort effort where NIH would be closely involved in aligning timelines, standards, policies, and deliverables across multiple moving parts.

The Coordinating Center’s role, as implied by the FOA’s stated purpose, is to serve as the hub that keeps the PMI Cohort Program coherent and operational as a single national enterprise. That typically means coordinating participating sites and partners, maintaining consistent processes over time, supporting participant engagement approaches, and enabling the collection and management of information suitable for long-term research use. Because the cohort is intended to be longitudinal and large, the coordinating function is central to maintaining continuity, harmonization, and program-level governance so that data and participant interactions remain reliable and usable over many years.

Eligibility is broad and intentionally inclusive, covering many types of entities that could credibly run a national coordinating operation. Eligible applicants include various levels of government (state, county, city/township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, other tribal organizations, public/Indian housing authorities, nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions where specified), for-profit organizations (other than small businesses), small businesses, and additional unspecified categories referenced as “Others” (with clarification typically provided in the full FOA text). The breadth of eligibility reflects the reality that a coordinating center could plausibly be housed in a university, a research institute, a nonprofit, a health system-affiliated organization, or a specialized coordinating entity with the administrative and technical capacity to manage a large national program.

The FOA was posted and created on November 16, 2015, with an application closing date of February 17, 2016 (no change between original and current closing dates in the provided record). NIH anticipated making one award, reinforcing that this was designed as a single coordinating hub rather than a network of multiple coordinating centers. The award ceiling is not specified in the provided data, which often means applicants needed to consult the full announcement for budget expectations, constraints, or negotiation details under the cooperative agreement terms.

In summary, this grant opportunity sought one awardee to build and operate the central Coordinating Center for a landmark NIH precision medicine cohort effort, with the explicit mission of enabling a one-million-plus volunteer cohort that would be followed over the long term. The intended outcome is a sustainable, participant-engaged national research platform capable of transforming understanding of the diverse factors that influence individual health trajectories and disease risk across the U.S. population.

Frequently Asked Questions (FAQs)

What is the funding opportunity being described?

It is the Precision Medicine Initiative Cohort Program Coordinating Center funding opportunity (U2C) under FOA number RFA-PM-16-001. It is an NIH cooperative agreement intended to establish and operate a single, central Coordinating Center for the Precision Medicine Initiative (PMI) Cohort Program.

Which agency is offering and administering this opportunity?

The opportunity is administered by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), listed as HHS/NIH (HHS-NIH11).

What is the CFDA number associated with this opportunity?

The opportunity is associated with CFDA number 93.310 (also listed as 93.310 in the source information provided).

What type of funding mechanism is this?

The mechanism is a cooperative agreement. This generally indicates substantial federal involvement in the project’s direction and oversight compared to a standard grant, which fits a national-scale program requiring alignment on timelines, standards, policies, and deliverables.

What is the main purpose of the Coordinating Center?

The core purpose is to provide infrastructure and day-to-day coordination needed to build and sustain a very large national research cohort. The Coordinating Center is intended to act as the hub that keeps the PMI Cohort Program coherent and operational as a single national enterprise.

What is the ultimate target size of the research cohort?

The program’s ultimate target is one million or more volunteers across the United States.

What makes the cohort’s participant model distinctive?

A defining feature is that participants are intended to be actively engaged as partners, not just passive study subjects, in a long-term longitudinal effort.

Is this meant to be a long-term study?

Yes. The cohort is described as long-term and longitudinal, with the expectation that participants and information would be followed and managed over many years for research use.

What kinds of responsibilities are implied for the Coordinating Center?

Based on the stated purpose, responsibilities typically include coordinating participating sites and partners, maintaining consistent processes over time, supporting participant engagement approaches, and enabling the collection and management of information suitable for long-term research use. The coordinating function is central to continuity, harmonization, and program-level governance.

How many awards did NIH anticipate making?

NIH anticipated making one award, reinforcing that the program was designed around a single central Coordinating Center rather than multiple coordinating hubs.

When was the FOA posted and created?

The FOA was posted and created on November 16, 2015.

What was the application closing date?

The application closing date was February 17, 2016. The provided record indicates no change between the original and current closing dates.

Is the award ceiling (maximum budget) specified in the information provided?

No. The award ceiling is not specified in the provided data, which typically means budget expectations and constraints would be found in the full funding announcement.

What funding activity area does this opportunity fall under?

It sits in the health funding activity area.

Who is eligible to apply?

Eligibility is broad and includes: state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions where specified); for-profit organizations (other than small businesses); small businesses; and additional categories referenced as “Others” (with details typically clarified in the full FOA text).

Why is eligibility so broad for this opportunity?

The breadth reflects that a national coordinating center could plausibly be housed in many types of organizations, such as a university, research institute, nonprofit, health system-affiliated organization, or a specialized coordinating entity with the capacity to manage a large national program.

What is the overall intended outcome of funding this Coordinating Center?

The intended outcome is a sustainable, participant-engaged national research platform capable of improving understanding of why individuals experience health and disease differently, supporting research into diverse factors influencing health trajectories and disease risk across the U.S. population.

Does the information provided describe multiple coordinating centers or a single center?

It describes a single, central Coordinating Center, supported by one anticipated award.

What does “U2C” refer to in this context?

In the information provided, U2C is presented as the activity code/structure tied to the Coordinating Center cooperative agreement for this program.

What does it mean that NIH would have “substantial involvement” under a cooperative agreement?

In practical terms (as described), it suggests NIH would be closely involved in aligning timelines, standards, policies, and deliverables across the program’s moving parts, which is especially important for a national cohort program that must remain consistent over time.

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