Opportunity Information: Apply for PA 10 089
Apply for PA 10 089
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Prevention and Management of Healthcare Associated Infections (R18)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
- This funding opportunity was created on Jan 21, 2010 and posted on Jan 21, 2010.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments State governments Private institutions of higher education County governments.
- Other Eligible Applicants include the following Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized).
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Opportunity Summary:
The Prevention and Management of Healthcare Associated Infections (R18) funding opportunity (PA 10-089) is a discretionary grant program from the Agency for Health Care Research and Quality (AHRQ) designed to support extramural health services research and real-world, practice-facing projects aimed at reducing healthcare associated infections (HAIs). It focuses on studies that do more than describe the problem by funding demonstration, dissemination, and evaluation work that can be applied in healthcare settings. In practical terms, the program is meant to move evidence into action by testing and spreading strategies that prevent HAIs or improve how they are managed once they occur, while also measuring what these approaches cost and what value they deliver.
The FOA is grounded in a multi-year research framework developed from several sources: existing peer-reviewed research, case studies, the Department of Health and Human Services 2009 National Action Plan on Healthcare Associated Infections, and qualitative insights gathered from listening sessions held in multiple US cities in 2009. The underlying public health rationale is that HAIs are infections patients acquire while receiving care for other conditions in any healthcare setting, and they represent a major and largely preventable source of harm. The announcement highlights the scale of the problem using widely cited estimates: about 1.7 million infections and 99,000 associated deaths in 2002, along with an estimated annual financial burden of roughly $28 to $33 billion in excess healthcare costs. By emphasizing both mortality and cost, the FOA signals that competitive proposals should connect clinical impact to operational and economic outcomes that matter to healthcare systems and payers.
AHRQ identifies three main research priority areas. First, it seeks projects that develop, implement, and demonstrate interventions to prevent and manage HAIs, paired with a clear assessment of the costs of those interventions. This points applicants toward implementation and delivery questions such as how an intervention is operationalized, what resources and workflow changes are required, and whether it is feasible and sustainable in routine practice. Second, the FOA prioritizes determining the efficacy, effectiveness, and costs of preventive interventions, which encourages comparative and outcomes-oriented evaluations that can distinguish what works under ideal conditions versus what works across typical healthcare environments. Third, it calls for population-level studies examining patient risk factors, clinical presentation, sources, and disease genotypes of antibiotic-resistant organisms that can be misidentified or perceived as HAIs, reflecting a concern with accurate attribution, epidemiology, and the evolving role of resistance in infection control.
The expected payoff of the funded work is practical and actionable knowledge: evidence about which approaches reduce infections, which strategies are implementable at scale, and which options are most cost-effective. In other words, the program is designed to help healthcare organizations and policymakers identify interventions that are not only scientifically sound but also workable in everyday care and justified by measurable improvements in outcomes and costs. Because the FOA explicitly includes dissemination and evaluation, strong applications would typically be expected to describe how results will be shared and adopted, how success will be measured, and how lessons learned can be translated beyond a single site.
From an administrative standpoint, the opportunity uses the R18 grant mechanism and is categorized under health, with CFDA 93.226 (Research on Healthcare Costs, Quality and Outcomes). It does not require cost sharing or matching. The opportunity was posted on January 21, 2010, with an original and current closing date of January 7, 2013, and an archive date of February 7, 2013. Eligible applicants include a broad mix of public and private entities such as state, county, city or township governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations. The eligibility description also notes additional eligible applicants such as faith-based or community-based organizations and Indian/Native American tribal governments that are not federally recognized, indicating the program’s openness to community and nontraditional research partners where they can contribute to applied infection prevention work.
The full announcement is linked through NIH’s grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-10-089.html, and the contact listed for access or linking issues is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Prevention and Management of Healthcare Associated Infections (R18) (PA-10-089)
What is the Prevention and Management of Healthcare Associated Infections (R18) funding opportunity?
It is a discretionary grant program from the Agency for Health Care Research and Quality (AHRQ) that supports extramural health services research and practice-facing projects aimed at reducing healthcare associated infections (HAIs). The opportunity is identified as PA 10-089 and uses the R18 grant mechanism.
What is the main purpose of this program?
The program is designed to move evidence into action by funding projects that test, spread (disseminate), and evaluate strategies to prevent HAIs or improve management of HAIs when they occur. It emphasizes real-world application in healthcare settings and expects projects to examine both outcomes and costs/value.
What kinds of projects does the FOA emphasize?
The FOA emphasizes studies that go beyond describing the HAI problem. It supports demonstration, dissemination, and evaluation work that can be applied in day-to-day healthcare environments, including assessment of implementation feasibility and sustainability.
What are healthcare associated infections (HAIs) in the context of this FOA?
HAIs are infections that patients acquire while receiving care for other conditions in any healthcare setting. The FOA frames HAIs as a major and largely preventable source of harm.
Why does AHRQ consider HAIs a priority area for funding?
The FOA cites widely used estimates to illustrate the public health and economic burden of HAIs, including about 1.7 million infections and 99,000 associated deaths in 2002, and an estimated $28 to $33 billion per year in excess healthcare costs. The framing signals that strong proposals should link clinical impact to operational and economic outcomes.
What are the main research priority areas under this FOA?
AHRQ identifies three main priority areas: (1) developing, implementing, and demonstrating interventions to prevent and manage HAIs, paired with assessment of intervention costs; (2) determining the efficacy, effectiveness, and costs of preventive interventions; and (3) conducting population-level studies on patient risk factors, clinical presentation, sources, and disease genotypes of antibiotic-resistant organisms that may be misidentified or perceived as HAIs.
What does the FOA mean by developing, implementing, and demonstrating interventions?
Based on the description, this includes practical, applied work focused on how an intervention is operationalized in real settings, what resources and workflow changes are needed, and whether the intervention is feasible and sustainable in routine practice, along with a clear accounting of costs.
Does the FOA support comparative evaluations of what works in different settings?
Yes. One priority area is determining the efficacy, effectiveness, and costs of preventive interventions, which points toward evaluations that distinguish what works under ideal conditions versus what works across typical healthcare environments.
How does antibiotic resistance fit into this funding opportunity?
The FOA includes a priority area focused on population-level studies examining antibiotic-resistant organisms that can be misidentified or perceived as HAIs, including patient risk factors, clinical presentation, sources, and disease genotypes. This reflects an emphasis on accurate attribution and evolving epidemiology related to resistance.
Is cost and economic value a required theme in applications?
Cost is explicitly emphasized throughout the FOA summary. Priority areas reference assessing intervention costs and determining the costs of preventive interventions, and the overall framing stresses measuring what approaches cost and what value they deliver (including operational and economic outcomes relevant to healthcare systems and payers).
What does the FOA suggest about dissemination and evaluation?
The FOA explicitly includes dissemination and evaluation. As described, competitive projects would typically be expected to explain how results will be shared and adopted, how success will be measured, and how lessons learned can be translated beyond a single site.
What is the expected outcome or payoff of funded projects?
The expected payoff is practical and actionable evidence about which approaches reduce infections, which strategies are implementable at scale, and which options are most cost-effective, helping healthcare organizations and policymakers identify interventions that are both workable and justified by measurable improvements in outcomes and costs.
What grant mechanism is used for this opportunity?
This opportunity uses the R18 grant mechanism.
Which agency is offering the grant?
The grant is offered by the Agency for Health Care Research and Quality (AHRQ).
What is the CFDA number for this program?
The CFDA is 93.226 (Research on Healthcare Costs, Quality and Outcomes).
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
Who is eligible to apply?
Eligible applicants include a broad mix of public and private entities, including state, county, city, or township governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations. The eligibility description also notes additional eligible applicants such as faith-based or community-based organizations and Indian/Native American tribal governments that are not federally recognized.
Does the FOA allow community-based or faith-based organizations to apply?
Yes. The eligibility description explicitly notes faith-based or community-based organizations among additional eligible applicants.
Are non-federally recognized tribal governments mentioned as eligible?
Yes. The eligibility description includes Indian/Native American tribal governments that are not federally recognized.
When was this funding opportunity posted?
It was posted on January 21, 2010.
What are the closing date and archive date listed?
The original and current closing date is listed as January 7, 2013, and the archive date is February 7, 2013.
Where can applicants find the full announcement?
The full announcement is linked through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-10-089.html.
Who is the contact for access or linking issues with the announcement?
The contact listed for access or linking issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of settings are relevant for these projects?
The FOA describes HAIs as occurring in any healthcare setting and emphasizes real-world, practice-facing projects that can be applied in healthcare environments, with attention to implementation, feasibility, and sustainability in routine care.
How does the FOA describe the evidence base and rationale behind the program?
The FOA is grounded in a multi-year research framework developed from peer-reviewed research, case studies, the 2009 HHS National Action Plan on Healthcare Associated Infections, and qualitative insights from listening sessions held in multiple US cities in 2009.
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