Opportunity Information: Apply for RFA RM 10 007
Apply for RFA RM 10 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Production Of Human Proteins To Be Used For Generating Affinity Reagents (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Feb 26, 2010 and posted on Feb 26, 2010.
- Applicants must submit their applications by Apr 26, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Native American tribal governments (Federally recognized) For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH funding opportunity, titled "Production Of Human Proteins To Be Used For Generating Affinity Reagents (U01)" (Funding Opportunity Number RFA-RM-10-007), is a pilot effort under the NIH Common Fund Protein Capture Initiative. The broader goal of the initiative is to test whether it is practical and worthwhile to build a widely accessible community resource of high-quality, renewable affinity reagents that, over time, could cover essentially all human proteins. In this particular announcement, the focus is on the upstream, enabling step: producing the proteins, peptides, or related immunogens that other teams can use to generate monoclonal antibodies, especially antibodies suitable for immunoprecipitation experiments. While immunoprecipitation is emphasized as a key use case, the program also anticipates that the produced reagents could support additional affinity-reagent formats and a range of downstream research applications across the broader scientific community.
The core deliverable being solicited is a dependable supply of targeted human protein materials (or peptide immunogens) that can feed into other components of the Protein Capture pilot program, including a separate effort expected to generate monoclonal antibodies (noted as planned for solicitation in FY2011). Importantly, the FOA is not only about producing one-off batches of proteins; it also stresses renewable community resources. That means applicants are expected to think in terms of outputs that can be shared and replenished over time, such as expression clones, standardized constructs, or transfected cell lines that enable continued production and distribution. As an initial target set, NIH indicates it will prioritize human transcription factors, reflecting both their biological importance and the historical difficulty many labs face in obtaining consistent, well-characterized reagents against them.
The award uses the U01 cooperative agreement mechanism, which typically implies substantial NIH program involvement and coordination compared with a standard investigator-initiated grant. In practice, this structure fits a resource-building project where NIH may help align priorities, harmonize standards, and ensure the outputs integrate smoothly with other program components and community needs.
In terms of funding, NIH anticipated making a single award, lasting up to three years, beginning in FY2010. Total program funds are described as $1 million per year for each of three years, and applications were instructed to request no more than $600,000 per year in direct costs, with a maximum project period of three years. There is no cost-sharing or matching requirement listed for applicants. The opportunity is categorized as discretionary funding and falls under NIH health-related research support (CFDA 93.310, Trans-NIH Research Support).
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants listed include state governments; federally recognized tribal governments and other Native American tribal organizations; U.S. territory or possession entities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education where specified); small businesses; other for-profit organizations; and additional categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities, eligible federal agencies, regional organizations, and foreign organizations. The sponsor agency is the National Institutes of Health.
Administratively, the opportunity was posted on February 26, 2010, with an original and current closing date of April 26, 2010, and an archive date of May 27, 2010. The announcement directs applicants to the full FOA text hosted on the NIH Grants Guide and provides NIH Office of Extramural Research contact points for technical access or link issues.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Production Of Human Proteins To Be Used For Generating Affinity Reagents (U01)."
What is the Funding Opportunity Number (FOA number)?
The FOA number is RFA-RM-10-007.
Which NIH program or initiative is this associated with?
This is a pilot effort under the NIH Common Fund Protein Capture Initiative.
What is the broader goal of the Protein Capture Initiative?
The broader goal is to test whether it is practical and worthwhile to build a widely accessible community resource of high-quality, renewable affinity reagents that, over time, could cover essentially all human proteins.
What is the main focus of this particular announcement?
This announcement focuses on producing the proteins, peptides, or related immunogens that other teams can use to generate affinity reagents, especially monoclonal antibodies.
What is the primary deliverable being solicited?
The core deliverable is a dependable supply of targeted human protein materials (or peptide immunogens) that can be used by other components of the Protein Capture pilot program.
Is this FOA about generating monoclonal antibodies directly?
No. The emphasis here is on producing the upstream protein/peptide materials or immunogens that enable other groups to generate monoclonal antibodies. A separate effort to generate monoclonal antibodies was described as planned for solicitation in FY2011.
What kinds of antibodies or use cases are emphasized?
Monoclonal antibodies suitable for immunoprecipitation experiments are emphasized as a key use case.
Are other downstream applications anticipated beyond immunoprecipitation?
Yes. The produced reagents are expected to support additional affinity-reagent formats and a range of downstream research applications across the broader scientific community.
Does NIH expect one-time production, or renewable resources?
The FOA stresses renewable community resources rather than one-off batches. Applicants are expected to plan for outputs that can be shared and replenished over time.
What are examples of renewable outputs mentioned in the announcement?
Examples include expression clones, standardized constructs, or transfected cell lines that enable continued production and distribution.
Is there an initial target set of human proteins NIH plans to prioritize?
Yes. NIH indicates it will prioritize human transcription factors as an initial target set.
Why are transcription factors prioritized?
They are prioritized due to their biological importance and the historical difficulty many labs face in obtaining consistent, well-characterized reagents against them.
What award mechanism is being used?
The opportunity uses the U01 cooperative agreement mechanism.
What does a U01 cooperative agreement generally imply for NIH involvement?
It typically implies substantial NIH program involvement and coordination compared with a standard investigator-initiated grant, fitting a resource-building project where NIH may help align priorities, harmonize standards, and integrate outputs with other program components and community needs.
How many awards did NIH anticipate making?
NIH anticipated making a single award.
What is the anticipated project period and start timing?
The project could last up to three years, beginning in FY2010.
What total funding level is described for the program?
Total program funds are described as $1 million per year for each of three years.
What is the maximum direct cost request allowed per year?
Applications were instructed to request no more than $600,000 per year in direct costs.
What is the maximum project duration allowed?
The maximum project period is three years.
Is there any cost-sharing or matching requirement?
No cost-sharing or matching requirement is listed.
How is this opportunity categorized in terms of funding type and program area?
It is categorized as discretionary funding and falls under NIH health-related research support.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.310 (Trans-NIH Research Support).
Who is the sponsor agency?
The sponsor agency is the National Institutes of Health (NIH).
What types of organizations are eligible to apply?
Eligibility is broad and includes U.S. and non-U.S. organizations such as state governments; federally recognized tribal governments and other Native American tribal organizations; U.S. territory or possession entities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education where specified); small businesses; other for-profit organizations; and additional categories including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities, eligible federal agencies, regional organizations, and foreign organizations.
Are foreign organizations eligible to apply?
Yes. Foreign organizations are listed among eligible applicants.
When was this funding opportunity posted?
It was posted on February 26, 2010.
What was the application closing date?
The original and current closing date was April 26, 2010.
When was the opportunity archived?
The archive date was May 27, 2010.
Where does the announcement direct applicants for the full FOA text?
It directs applicants to the full FOA text hosted on the NIH Grants Guide.
Who should applicants contact if they have technical access problems or link issues?
The announcement provides NIH Office of Extramural Research contact points for technical access or link issues.
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