Opportunity Information: Apply for CDC RFA GH11 11500501SUPP16
Apply for CDC RFA GH11 11500501SUPP16
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Aug 18, 2016.
- Applicants must submit their applications by Oct 17, 2016 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $832,078.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR" is a U.S. Centers for Disease Control and Prevention (CDC) funding announcement issued under the U.S. Department of Health and Human Services. It is structured as a cooperative agreement, meaning CDC would stay actively involved in the work rather than simply providing a hands-off award. The overall aim is to expand voluntary medical male circumcision (VMMC) services in South Africa as a core HIV prevention strategy supported through PEPFAR, focusing specifically on 27 high-burden districts and additional sub-districts where male circumcision prevalence remains low.
This announcement is a supplement designed to provide additional funds to existing CDC South Africa partners rather than opening competition broadly to new organizations. The listed recipients are The South African Clothing and Textile Workers Union (SACTWU, award GH000265), Jhpiego (GH000237), and Population Services International (PSI, GH000248). The intent is to accelerate and scale up delivery capacity in priority geographies, expanding service availability and reach in areas with the greatest need and the lowest baseline coverage.
The public health rationale for the award is grounded in strong scientific evidence that VMMC is a highly effective, one-time biomedical intervention that lowers a mans lifetime risk of acquiring HIV through heterosexual exposure. The announcement cites three randomized controlled trials demonstrating roughly a 60 percent reduction in male HIV acquisition risk, with longer-term follow-up from trials in Uganda and Kenya showing that protection persisted and in some analyses increased over time. These findings underpin the global policy stance taken by WHO and UNAIDS, which in 2007 recognized VMMC as an important additional HIV prevention measure in settings with generalized epidemics and low circumcision prevalence.
The opportunity also places South Africas VMMC scale-up in the context of broader regional targets and impact projections. WHO/UNAIDS strategy set a benchmark of 80 percent circumcision coverage among males aged 15 to 49 across 14 priority countries, a goal framed as both feasible and transformative for epidemic control. Modeling cited in the announcement suggests that rapidly achieving high coverage (around 8 in 10 adult men circumcised within five years) could avert millions of new HIV infections over 15 years and generate very large savings in HIV treatment and care costs. For South Africa specifically, the modeling scenario highlighted suggests an approximate ratio of one HIV infection prevented for every five men circumcised, underscoring the intervention's cost-effectiveness and prevention value when implemented at scale.
Beyond the direct protective benefit to men, the announcement emphasizes the broader prevention and health-system advantages that come with VMMC programming. VMMC service platforms create a practical entry point to engage men who may otherwise have limited contact with health services, allowing programs to deliver prevention education and routinely provide HIV testing and counseling as part of the VMMC package. Another key component is linkage: men found to be HIV-positive through VMMC-related testing are referred into HIV care and treatment. This is positioned as a community-level prevention gain because effective antiretroviral treatment reduces onward transmission risk.
The FOA also highlights indirect but meaningful benefits for women. As fewer men acquire HIV due to circumcision, womens risk declines because the likelihood of encountering an HIV-infected partner decreases. The cited modeling indicates that if scale-up is fast, nearly half of infections averted could be among women, even though the medical procedure is performed on men. The announcement additionally notes that female partners of circumcised men may experience reduced risk of certain sexually transmitted infections, including high-risk strains of HPV linked to cervical cancer, pointing to wider sexual and reproductive health benefits beyond HIV prevention.
Administratively, the funding opportunity is identified as CDC RFA GH11-11500501SUPP16, categorized under discretionary funding and health-related activities (CFDA 93.067). The posting date listed is August 18, 2016, with an original application deadline of October 17, 2016, and electronic submissions due by 11:59 p.m. Eastern Time on the closing date. The announcement lists an award ceiling of $832,078 and indicates an expectation of one award, consistent with a targeted supplement mechanism for established partners rather than an open multi-award competition. Overall, the grant is designed to add resources to proven implementers so they can expand VMMC service delivery in the districts where increased coverage is expected to have the greatest effect on South Africas HIV epidemic.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR."
Which U.S. agency is offering this funding announcement?
The funding announcement is issued by the U.S. Centers for Disease Control and Prevention (CDC) under the U.S. Department of Health and Human Services.
What type of award mechanism is being used?
This opportunity is structured as a cooperative agreement, meaning CDC would remain actively involved in the work rather than providing a fully hands-off award.
What is the main purpose of the supplement?
The purpose is to provide additional funds to expand voluntary medical male circumcision (VMMC) service delivery capacity in South Africa, accelerating scale-up in priority geographies where need is greatest and baseline coverage is lowest.
Is this an open competition for new applicants?
No. This is a supplement designed to provide additional funds to existing CDC South Africa partners rather than opening competition broadly to new organizations.
Who are the listed recipients for this supplement?
The listed recipients are The South African Clothing and Textile Workers Union (SACTWU, award GH000265), Jhpiego (GH000237), and Population Services International (PSI, GH000248).
Where will the funded activities take place?
The activities focus on South Africa, specifically targeting 27 high-burden districts and additional sub-districts where male circumcision prevalence remains low.
What program area is being expanded?
The program area is voluntary medical male circumcision (VMMC), described as a core HIV prevention strategy supported through PEPFAR.
Why is VMMC being prioritized as an HIV prevention strategy?
The public health rationale cited is strong scientific evidence that VMMC is a highly effective, one-time biomedical intervention that lowers a man's lifetime risk of acquiring HIV through heterosexual exposure.
What evidence is cited for the effectiveness of VMMC?
The announcement cites three randomized controlled trials showing roughly a 60 percent reduction in male HIV acquisition risk. It also references longer-term follow-up from trials in Uganda and Kenya indicating that protection persisted and, in some analyses, increased over time.
How does this align with global public health guidance?
The announcement notes that WHO and UNAIDS recognized VMMC in 2007 as an important additional HIV prevention measure in settings with generalized epidemics and low circumcision prevalence.
What coverage benchmark is referenced in the announcement?
The WHO/UNAIDS strategy benchmark referenced is 80 percent circumcision coverage among males aged 15 to 49 across 14 priority countries.
What impact does modeling suggest could result from rapid scale-up?
Modeling cited suggests that rapidly achieving high coverage (around 8 in 10 adult men circumcised within five years) could avert millions of new HIV infections over 15 years and generate large savings in HIV treatment and care costs.
What specific impact estimate is highlighted for South Africa?
The highlighted modeling scenario for South Africa suggests an approximate ratio of one HIV infection prevented for every five men circumcised.
Besides the procedure itself, what services are commonly delivered through VMMC platforms?
The announcement emphasizes that VMMC platforms can be used to engage men who may otherwise have limited contact with health services, including delivery of prevention education and routine HIV testing and counseling as part of the VMMC package.
What happens if someone tests HIV-positive through VMMC-related services?
Men found to be HIV-positive through VMMC-related testing are referred and linked to HIV care and treatment.
How does linking HIV-positive clients to treatment contribute to prevention?
The announcement describes linkage to antiretroviral treatment as a community-level prevention gain because effective treatment reduces onward transmission risk.
Does the announcement describe benefits for women?
Yes. It notes that as fewer men acquire HIV due to circumcision, women's risk declines because they are less likely to encounter an HIV-infected partner.
What does the modeling indicate about infections averted among women?
The cited modeling indicates that if scale-up is fast, nearly half of infections averted could be among women, even though the medical procedure is performed on men.
Are any additional sexual and reproductive health benefits mentioned beyond HIV prevention?
Yes. The announcement notes that female partners of circumcised men may have reduced risk of certain sexually transmitted infections, including high-risk strains of HPV linked to cervical cancer.
What is the funding opportunity identification number?
The opportunity is identified as CDC RFA GH11-11500501SUPP16.
How is the opportunity categorized?
It is categorized under discretionary funding and health-related activities, with CFDA 93.067.
What is the posting date for the announcement?
The posting date listed is August 18, 2016.
What was the application deadline?
The original application deadline was October 17, 2016.
What time were electronic submissions due on the closing date?
Electronic submissions were due by 11:59 p.m. Eastern Time on the closing date.
What is the award ceiling listed in the announcement?
The award ceiling is $832,078.
How many awards does the announcement expect to make?
The announcement indicates an expectation of one award, consistent with a targeted supplement mechanism for established partners rather than an open multi-award competition.
How does this supplement fit within PEPFAR programming in South Africa?
The supplement is positioned as a way to add resources to proven implementers to expand VMMC service delivery in the districts where increased coverage is expected to have the greatest effect on South Africa's HIV epidemic.
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