Opportunity Information: Apply for PA 07 252

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Proteomics in Auditory Developmental and Disease Processes (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders.
  • This funding opportunity was created on Dec 5, 2008 and posted on Dec 20, 2006.
  • Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) For profit organizations other than small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments.
  • Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:

The Proteomics in Auditory Developmental and Disease Processes (R01) opportunity (Funding Opportunity Number PA 07-252) is a National Institutes of Health program led by the National Institute on Deafness and Other Communication Disorders (NIDCD) that supports research using proteomics to better understand how the auditory system develops and how hearing-related diseases and disorders arise and progress. In practical terms, the announcement is looking for R01-scale projects that apply modern protein science tools and strategies to questions in hearing and balance biology, including the identification, measurement, and functional interpretation of proteins and protein networks that shape normal auditory development or contribute to pathology. The emphasis on proteomics signals interest in work that goes beyond single-gene or single-protein studies and instead examines broader protein expression patterns, post-translational modifications, protein-protein interactions, and pathway-level changes that may explain mechanisms of disease, reveal biomarkers, or point to new therapeutic targets in auditory disorders.

This FOA uses the NIH Research Project Grant (R01) mechanism, which is designed for substantial, hypothesis-driven research programs with clear aims, rigorous methods, and a strong plan for producing generalizable biological insight. The program is explicitly paired with a companion announcement of the same scientific scope that uses the R21 mechanism (PA 06-366), which is typically geared toward earlier-stage, exploratory, or high-risk/high-reward studies. Taken together, the parallel R01 and R21 options indicate that NIH intended to support both mature, comprehensive proteomics-driven auditory research projects (R01) and more preliminary or proof-of-concept efforts (R21), with this specific listing being the R01 pathway.

Funding levels and the number of awards are not fixed in advance. Instead, NIH indicates that award size and duration will vary depending on what applicants propose, and that the total number of funded projects and the overall dollars committed will depend on the mix of applications received, their scientific quality, the proposed project periods, and the requested budgets. This is a common NIH approach for program announcements where the institute wants to encourage a range of strong applications rather than constrain the field to a narrow budget cap or a predetermined award count.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, as described), state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, small businesses, and other for-profit organizations. The eligibility language also clarifies that foreign institutions are allowed to apply, that eligible federal government agencies may apply, and that faith-based or community-based organizations are not excluded. The announcement states there is no cost sharing or matching requirement, so applicants are not expected to provide mandatory non-federal matching funds as a condition of receiving an award.

Administratively, the opportunity sits in the health funding category and is associated with CFDA 93.173 (Research Related to Deafness and Communication Disorders). It was posted on December 20, 2006, and offered multiple receipt dates rather than a single deadline, meaning applications could be submitted on the standard NIH due dates that applied during the active period of the FOA. The listing indicates an archive date of August 5, 2009, which reflects that the specific announcement is no longer active, though the scientific topic may have continued under later NIH notices or reissued program announcements. The full announcement was hosted on the NIH grants guide site, and NIH provided contact information for the Office of Extramural Research (OER) webmaster for access or linking issues.

Frequently Asked Questions (FAQs): Proteomics in Auditory Developmental and Disease Processes (R01) - PA 07-252

What is the name and purpose of this funding opportunity?

The opportunity is titled Proteomics in Auditory Developmental and Disease Processes (R01) (Funding Opportunity Number PA 07-252). It is a National Institutes of Health (NIH) program led by the National Institute on Deafness and Other Communication Disorders (NIDCD). It supports research that uses proteomics to better understand how the auditory system develops and how hearing-related diseases and disorders arise and progress.

Which NIH institute leads this program?

This program is led by the National Institute on Deafness and Other Communication Disorders (NIDCD).

What grant mechanism does this opportunity use?

This announcement uses the NIH Research Project Grant (R01) mechanism, which is intended for substantial, hypothesis-driven research programs with clear aims, rigorous methods, and a plan to generate generalizable biological insight.

What kinds of projects does the FOA encourage?

The FOA encourages R01-scale projects that apply modern protein science tools and strategies to questions in hearing and balance biology. The intent is to use proteomics approaches to understand normal auditory development and the mechanisms that contribute to auditory pathology.

What does "proteomics" mean in the context of this FOA?

In this FOA, proteomics signals interest in research that goes beyond single-gene or single-protein studies and instead examines broader protein biology, including:

  • Protein identification and measurement
  • Protein expression patterns at broader scale
  • Post-translational modifications
  • Protein-protein interactions
  • Pathway-level and network-level changes

What types of scientific outcomes is the FOA aiming to support?

Based on the description provided, the FOA is interested in proteomics-driven work that may help explain disease mechanisms, reveal biomarkers, or point toward new therapeutic targets in auditory disorders.

Is this limited to studies of hearing, or does it include balance?

The scope explicitly includes questions in hearing and balance biology.

How does the R01 version relate to the R21 version mentioned?

This R01 FOA (PA 07-252) is described as being explicitly paired with a companion announcement with the same scientific scope using the R21 mechanism (PA 06-366). The pairing indicates an intent to support both:

  • Mature, comprehensive proteomics-driven auditory research projects (R01)
  • Earlier-stage, exploratory or high-risk/high-reward studies (R21)

This listing is specifically the R01 pathway.

Are funding amounts and the number of awards fixed?

No. NIH indicates that funding levels and the number of awards are not fixed in advance. Award size and duration vary based on what applicants propose, and the number of funded projects and total funds committed depend on the mix of applications received, their scientific quality, the proposed project periods, and the requested budgets.

Is cost sharing or matching required?

No. The announcement states there is no cost sharing or matching requirement, meaning applicants are not required to provide mandatory non-federal matching funds as a condition of receiving an award.

Who is eligible to apply?

Eligibility is described as broad and includes many types of U.S.-based organizations and governmental entities, including:

  • Public and private institutions of higher education
  • Nonprofit organizations (including those with and without 501(c)(3) status, as described)
  • State and local governments
  • Tribal governments and tribal organizations
  • Independent school districts
  • Special district governments
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Other for-profit organizations

Are foreign institutions eligible to apply?

Yes. The eligibility language clarifies that foreign institutions are allowed to apply.

Can federal government agencies apply?

Yes. The eligibility language indicates that eligible federal government agencies may apply.

Are faith-based or community-based organizations excluded?

No. The eligibility language clarifies that faith-based or community-based organizations are not excluded.

What is the funding category and CFDA number associated with this opportunity?

The opportunity is in the health funding category and is associated with CFDA 93.173 (Research Related to Deafness and Communication Disorders).

When was this opportunity posted?

The listing indicates it was posted on December 20, 2006.

Did this FOA have a single deadline?

No. The listing describes multiple receipt dates rather than a single deadline, meaning applications could be submitted on the standard NIH due dates that applied during the active period of the FOA.

Is this FOA still active?

No. The listing indicates an archive date of August 5, 2009, which reflects that this specific announcement is no longer active.

Does the archive date mean the scientific topic is no longer supported by NIH?

Not necessarily. The information provided notes that while this specific announcement is archived, the scientific topic may have continued under later NIH notices or reissued program announcements.

Where was the full announcement hosted?

The full announcement was hosted on the NIH grants guide site.

Who was listed as a contact for access or linking issues?

NIH provided contact information for the Office of Extramural Research (OER) webmaster for access or linking issues.

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