Opportunity Information: Apply for PA 07 253
Apply for PA 07 253
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Structural Biology of Membrane Proteins (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training 93.866 Aging Research.
- This funding opportunity was created on May 19, 2009 and posted on Dec 20, 2006.
- Applicants must submit their applications by Jan 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) County governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) Special district governments State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Structural Biology of Membrane Proteins (R01) opportunity (Funding Opportunity Number PA-07-253) is a National Institutes of Health (NIH) research grant program aimed at speeding up and improving how scientists determine the three-dimensional structures of membrane proteins. Membrane proteins are often difficult to study because they sit in or span lipid membranes, making them harder to express, isolate, stabilize, and analyze than many soluble proteins. The central goal of this program is to support projects that either (1) create better tools, workflows, and enabling technologies that increase the overall rate of membrane protein structure determination, or (2) directly produce high-value membrane protein structures in the near term, particularly for proteins with clear biological significance.
The FOA strongly encourages innovation across the full pipeline required to get from a membrane protein gene to a solved structure. That includes new or improved approaches for protein expression (including challenging targets and systems), managing oligomerization and complex formation, solubilization strategies (such as detergents, lipid mimetics, or other membrane-like environments), stabilization methods that preserve native-like conformations, purification and biochemical/biophysical characterization, crystallization approaches, isotopic labeling strategies (especially relevant for NMR), and downstream structure determination and validation. A wide range of structure-solving and supporting methods are considered responsive, including X-ray diffraction, NMR, electron microscopy, mass spectrometry, and other biophysical techniques. In practical terms, NIH is signaling interest in both platform-type projects that remove bottlenecks for the whole field and target-driven projects that can deliver specific structures soon, as long as they address important biological questions or unlock broader scientific value.
Awards are made using the NIH Research Project Grant (R01) mechanism, which generally supports investigator-initiated research projects with substantial scientific scope. The announcement does not specify a fixed budget cap or a set number of awards. Instead, it emphasizes that award size and duration may vary depending on the proposed work, and that the total number and amount of awards will ultimately depend on application quality, project period, and requested costs. There is no cost sharing or matching requirement, which means applicants are not required to commit institutional funds as a condition of receiving an award.
This FOA is listed as discretionary funding and spans multiple NIH-related program areas, reflected by the CFDA numbers associated with environmental health, deafness and communication disorders, mental health, cancer biology, cardiovascular research, arthritis and musculoskeletal/skin diseases, diabetes/digestive/kidney research, neuroscience and neurological disorders, general biomedical research and training, and aging research. That breadth underscores that membrane protein structures are relevant across many disease areas and biological systems, from receptors and channels to transporters and enzymes that are frequent drug targets.
Eligibility is broad. Applicants may include public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit types), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, and public housing authorities, among others. The announcement also specifies that foreign institutions are eligible, eligible federal agencies may apply, and faith-based or community-based organizations may apply. This wide eligibility reflects NIH interest in attracting strong proposals wherever the expertise and capabilities exist, including international centers with specialized membrane protein infrastructure.
Key administrative details include a posted date of December 20, 2006, with multiple receipt dates (rather than a single deadline) during the active period of the FOA. The current closing date in the source data is January 7, 2010, with an archive date of February 7, 2010, indicating that this particular announcement has been closed and archived; however, it remains useful as a reference for NIH priorities and the kinds of membrane protein structural biology projects NIH has historically encouraged. The full announcement was hosted through NIH’s grants guide (PA-07-253), and NIH’s Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
In short, this R01 opportunity was designed to push the membrane protein structural biology field forward by funding either enabling methods that make structure determination faster and more reliable, or focused projects that can deliver important membrane protein structures soon, using any suitable combination of modern structural and biophysical approaches.
Frequently Asked Questions (FAQs): Structural Biology of Membrane Proteins (R01) - PA-07-253
1) What is the purpose of the Structural Biology of Membrane Proteins (R01) opportunity (PA-07-253)?
This NIH Funding Opportunity Announcement (FOA) supports research aimed at speeding up and improving the determination of three-dimensional (3D) structures of membrane proteins. The emphasis is on overcoming the practical bottlenecks that make membrane proteins hard to express, isolate, stabilize, and analyze, and on accelerating the pace and reliability of membrane protein structure determination.
2) Why does this FOA focus specifically on membrane proteins?
Membrane proteins are often more difficult to study than soluble proteins because they sit in or span lipid membranes. That property makes them harder to express, solubilize, purify, stabilize in a native-like form, and ultimately solve structurally. The FOA is designed to address these challenges across the full experimental pipeline.
3) What types of projects are responsive to this FOA?
The FOA supports two broad categories of projects: (1) projects that develop better tools, workflows, and enabling technologies that increase the overall rate of membrane protein structure determination, and (2) projects that directly produce high-value membrane protein structures in the near term, particularly when the targets have clear biological significance.
4) Does NIH prefer technology/platform projects or target-driven structure projects?
Both are within scope. NIH signals interest in platform-type projects that remove bottlenecks for the broader field and in target-driven projects that can deliver specific structures soon, provided they offer important biological significance or broader scientific value.
5) Which parts of the membrane protein structure pipeline does the FOA encourage applicants to innovate in?
The FOA strongly encourages innovation across the full pipeline from a membrane protein gene to a solved structure. Examples mentioned include improved approaches for protein expression, handling oligomerization and complex formation, solubilization strategies, stabilization methods, purification and characterization, crystallization, isotopic labeling (notably for NMR), and downstream structure determination and validation.
6) What solubilization or membrane-mimetic approaches are considered relevant under this FOA?
The FOA calls out solubilization strategies such as detergents, lipid mimetics, or other membrane-like environments as responsive areas of innovation, particularly where they improve stability and preserve native-like conformations for structure work.
7) What structure determination methods are considered responsive?
A wide range of structure-solving and supporting methods are considered responsive, including X-ray diffraction, NMR, electron microscopy, mass spectrometry, and other biophysical techniques.
8) Does the FOA mention validation of structures?
Yes. In addition to structure determination, the FOA explicitly includes downstream structure determination and validation as part of the encouraged pipeline improvements.
9) What grant mechanism is used for awards under this opportunity?
Awards are made using the NIH Research Project Grant (R01) mechanism, which is commonly used for investigator-initiated research projects with substantial scientific scope.
10) Is there a fixed budget cap or a fixed number of awards?
No. The announcement does not specify a fixed budget cap or set number of awards. Award size and duration may vary depending on the proposed work, and the total number and amount of awards depend on factors including application quality, project period, and requested costs.
11) Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to commit institutional funds as a condition of receiving an award.
12) What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is PA-07-253, and the opportunity is titled "The Structural Biology of Membrane Proteins (R01)."
13) Which scientific and disease areas does this FOA connect to?
The FOA spans multiple NIH-related program areas (reflected by multiple CFDA numbers), including environmental health; deafness and communication disorders; mental health; cancer biology; cardiovascular research; arthritis and musculoskeletal/skin diseases; diabetes/digestive/kidney research; neuroscience and neurological disorders; general biomedical research and training; and aging research. This breadth reflects the cross-cutting relevance of membrane proteins, including receptors, channels, transporters, and enzymes that are common drug targets.
14) Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit types), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, independent school districts, special district governments, and public housing authorities, among others.
15) Are foreign institutions eligible to apply?
Yes. The announcement specifies that foreign institutions are eligible.
16) Can federal agencies apply?
Yes. The FOA specifies that eligible federal agencies may apply.
17) Can faith-based or community-based organizations apply?
Yes. The announcement specifies that faith-based or community-based organizations may apply.
18) What does the FOA say about deadlines and submission timing?
The FOA indicates multiple receipt dates during its active period rather than a single deadline. Administrative details list a posted date of December 20, 2006.
19) Is this FOA still open?
No. The source data lists a closing date of January 7, 2010 and an archive date of February 7, 2010, indicating this specific announcement has been closed and archived.
20) If the FOA is archived, why is it still useful?
Even though PA-07-253 is closed, it remains useful as a reference for NIH priorities and for understanding the kinds of membrane protein structural biology projects NIH has historically encouraged, including both enabling technology development and near-term determination of high-value structures.
21) Where was the full announcement hosted?
The full announcement was hosted through NIH's grants guide as PA-07-253.
22) Who was the listed contact for access or linking issues?
The FOA notes that NIH's Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
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| Exploratory Innovations in Biomedical Computational Science and Technology (R21) Apply for PAR 09 219 Funding Number: PAR 09 219 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
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