Provocative Questions in Cancer with an Underlying HIV Infection (R21) | Apply Online

Opportunity Summary:

The grant opportunity titled "Provocative Questions in Cancer with an Underlying HIV Infection (R21)" (Funding Opportunity Number RFA-CA-15-013) is a National Institutes of Health (NIH) funding announcement aimed at pushing forward research on cancers that occur in people living with HIV or with AIDS. The central goal is to improve scientific understanding of how cancer risk emerges, how these malignancies develop and progress over time, how they can be detected and diagnosed more effectively, and how they can be treated in the context of HIV-related immune dysfunction and clinical complexity. Instead of broadly funding any HIV-and-cancer topic, the announcement is built around a set of targeted "Provocative Questions" (PQs). These questions are designed to spotlight important but under-studied problems, contradictions, and gaps in knowledge within AIDS-related cancer research, essentially nudging investigators to tackle issues that may be scientifically challenging, conceptually overlooked, or difficult to study with traditional approaches.

This is an R21 mechanism, meaning it supports exploratory and developmental research projects. In practice, R21 awards are often used to seed early-stage, high-impact ideas, pilot studies, and novel directions that can generate key data or proof-of-concept results. The opportunity emphasizes research that is explicitly aligned with one of the proposed Provocative Questions rather than simply being generally relevant to HIV and cancer. The PQ framing signals that reviewers will be looking for applications that directly address the specific unanswered questions highlighted by the National Cancer Institute (NCI), rather than incremental extensions of existing work. It also indicates that the FOA is not intended to represent the entire NCI HIV/AIDS cancer research portfolio; it is a deliberately selective call intended to draw attention to areas that have not received enough focused investigation.

Administratively, this opportunity falls under the NIH and is categorized as discretionary grant funding within the health and education activity space. It is associated with CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.395 (Cancer Treatment Research). The announcement states there is no cost sharing or matching requirement, so applicants are not expected to provide matching funds as a condition of receiving an award. The estimated total funding level listed is $4,000,000, and the award ceiling is $200,000, which reflects the maximum direct cost level indicated in the summary information provided.

Eligibility is broad and includes many types of organizations capable of conducting biomedical and behavioral research. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profits), state and county governments, and other entities as permitted under NIH rules. The eligibility details also explicitly include a wide range of institutions and organizational categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, the FOA also allows non-domestic (non-U.S.) entities (foreign organizations), regional organizations, eligible federal agencies, and U.S. territories or possessions, which expands the potential applicant pool to groups that can contribute international cohorts, diverse populations, and cross-border expertise relevant to HIV-associated malignancies.

The timeline information in the provided source indicates the FOA was posted and created on May 14, 2015. The original and current closing date listed is August 18, 2016, and the archive date is September 18, 2016, meaning it was a time-limited opportunity that has since been archived. For applicants or researchers looking to understand the full scope of the Provocative Questions and the required application elements, the official announcement was made available through NIH at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-15-013.html). For technical access issues, the contact route listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

Overall, the opportunity can be summarized as a targeted, question-driven NIH/NCI R21 call meant to catalyze creative, hypothesis-generating, and potentially high-yield research focused on cancers in people with HIV/AIDS, especially in areas where the science presents unresolved puzzles or has not kept pace with clinical need.

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Next opportunity: Provocative Questions (PQ) Initiative Cancer with an Underlying HIV Infection (R01)

Previous opportunity: BJA FY 15 Technology Innovation for Public Safety (TIPS)

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