Opportunity Information: Apply for RFA CA 15 012
Apply for RFA CA 15 012
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Provocative Questions (PQ) Initiative Cancer with an Underlying HIV Infection (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395 Cancer Treatment Research 93.396 Cancer Biology Research.
- This funding opportunity was created on May 14, 2015 and posted on May 14, 2015.
- Applicants must submit their applications by Aug 18, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Provocative Questions (PQ) Initiative: Cancer with an Underlying HIV Infection (R01) (Funding Opportunity Number RFA-CA-15-012) is a National Institutes of Health funding opportunity designed to push HIV-associated cancer research into areas that are important but historically underexplored. The central aim is to improve understanding of how cancers arise, behave, are detected, and are treated in people living with HIV or with AIDS. Rather than funding broad or general HIV/cancer projects, this announcement is structured around a set of specific "Provocative Questions" meant to spotlight unresolved issues, contradictions, and knowledge gaps in the field. The overall idea is to encourage researchers to tackle problems that may be scientifically challenging, conceptually unconventional, or neglected because they do not fit neatly into more traditional research pathways.
This opportunity uses the NIH R01 mechanism, meaning it supports discrete, hypothesis-driven research projects that can range from basic and mechanistic studies to translational and clinically oriented work, as long as the research directly addresses one of the designated Provocative Questions. The scientific scope centers on malignancies observed in individuals with underlying HIV infection, which can include cancers strongly associated with immune suppression and oncogenic viruses as well as cancers that may be rising in incidence as HIV-positive individuals live longer due to effective antiretroviral therapy. The FOA emphasizes major stages and angles of the cancer problem in this population: risk and susceptibility, biological mechanisms of development and progression, challenges in diagnosis and screening, and issues surrounding treatment effectiveness, toxicity, and outcomes. A key feature is that it is not meant to reflect the entire portfolio of the National Cancer Institute's priorities in HIV/AIDS cancer research; instead, it targets select questions judged to be especially compelling and insufficiently studied, with the intent of catalyzing new lines of inquiry.
From an administrative and funding standpoint, this is a discretionary grant program within health and education-related federal funding categories. It is tied to CFDA numbers 93.395 (Cancer Treatment Research) and 93.396 (Cancer Biology Research), reflecting that both treatment-focused and biology-focused proposals are relevant if aligned with the PQ framework. The estimated total funding amount listed for the initiative is $4,000,000, and the program does not require cost sharing or matching, which is typical for many NIH research grants.
Eligibility is broad and includes a wide range of organizational types. Domestic applicants can include public and private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses), and various levels of government such as state and county governments. The eligibility language also explicitly includes institutions and organizations that serve specific populations and regions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). In addition, the FOA allows participation by non-U.S. entities (foreign organizations), regional organizations, eligible federal agencies, and U.S. territories or possessions, indicating an openness to globally relevant research where HIV-associated cancers are a significant concern.
In terms of timing, the opportunity was posted and created on May 14, 2015, with an original and current closing date of August 18, 2016, and an archive date of September 18, 2016. The archived status indicates the competition window has closed, but the announcement remains useful as a reference for how the NCI framed priorities and knowledge gaps at the time, and it can also help prospective applicants anticipate the types of questions and approaches that may appear in future PQ-driven or HIV-associated malignancy initiatives.
The sponsoring agency is the National Institutes of Health, and the full announcement was made available through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-15-012.html). For access issues or technical problems related to the online posting, the contact point listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: The Provocative Questions (PQ) Initiative - Cancer with an Underlying HIV Infection (R01) (RFA-CA-15-012)
What is this funding opportunity?
This opportunity is the National Institutes of Health (NIH) Provocative Questions (PQ) Initiative focused on cancers occurring in people with an underlying HIV infection (including AIDS). It uses the NIH R01 grant mechanism and is identified by Funding Opportunity Number RFA-CA-15-012.
What is the purpose of the Provocative Questions (PQ) approach?
The PQ approach is meant to push HIV-associated cancer research toward important problems that have historically been underexplored. Instead of supporting broad or general projects, it spotlights a defined set of specific "Provocative Questions" intended to highlight unresolved issues, contradictions, and key knowledge gaps.
What is the central scientific aim of the initiative?
The central aim is to improve understanding of how cancers arise, behave, are detected, and are treated in people living with HIV or with AIDS, specifically by encouraging research that directly addresses one of the designated Provocative Questions.
Does this FOA fund general HIV/cancer research projects?
No. The FOA is structured to avoid broad or general HIV/cancer projects. Applications are expected to align with one of the specific Provocative Questions identified by the announcement.
What grant mechanism is used?
The opportunity uses the NIH R01 mechanism, which supports discrete, hypothesis-driven research projects. Projects can range from basic and mechanistic work to translational and clinically oriented studies, as long as they directly address one of the designated Provocative Questions.
What types of cancer are in scope?
The scientific scope centers on malignancies observed in individuals with underlying HIV infection. This includes cancers strongly associated with immune suppression and oncogenic viruses, as well as cancers that may be increasing in incidence as people with HIV live longer due to effective antiretroviral therapy.
What areas of research does the FOA emphasize?
The FOA emphasizes major stages and angles of the cancer problem in people with HIV, including risk and susceptibility; biological mechanisms of cancer development and progression; challenges in diagnosis and screening; and treatment effectiveness, toxicity, and outcomes.
Is this opportunity intended to represent the full NCI HIV/AIDS cancer research portfolio?
No. The FOA explicitly states that it is not meant to reflect the entire portfolio of the National Cancer Institute's priorities in HIV/AIDS cancer research. It targets select questions judged to be especially compelling and insufficiently studied, with the goal of catalyzing new lines of inquiry.
What is the estimated total funding amount for the initiative?
The estimated total funding amount listed for the initiative is $4,000,000.
Is cost sharing or matching required?
No. The program does not require cost sharing or matching.
Which federal funding categories and CFDA numbers are associated with this opportunity?
This is described as a discretionary grant program within health and education-related federal funding categories. It is tied to CFDA 93.395 (Cancer Treatment Research) and CFDA 93.396 (Cancer Biology Research), indicating that both treatment-focused and biology-focused proposals may be relevant if aligned with the PQ framework.
Who can apply (eligibility overview)?
Eligibility is broad and includes many organization types. Domestic applicants can include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses), and various levels of government (such as state and county governments).
Are specific institution types explicitly included?
Yes. The eligibility language explicitly includes institutions and organizations serving specific populations and regions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign or international organizations eligible to participate?
Yes. The FOA allows participation by non-U.S. entities (foreign organizations), regional organizations, eligible federal agencies, and U.S. territories or possessions.
When was the opportunity posted, and what were the key dates?
The opportunity was posted and created on May 14, 2015. The original and current closing date was August 18, 2016, and the archive date was September 18, 2016.
Is this funding opportunity still open?
No. The opportunity is archived, and the archived status indicates the competition window has closed.
If it is archived, why might it still be useful?
Even though it is closed, it can still serve as a reference for how the National Cancer Institute framed priorities and knowledge gaps at the time. It may also help prospective applicants anticipate the types of questions and approaches that could appear in future PQ-driven or HIV-associated malignancy initiatives.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where can I find the full FOA announcement?
The full announcement is available through the NIH grants guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-15-012.html
Who is listed as a contact for access issues or technical problems with the online posting?
For access issues or technical problems related to the online posting, the contact point listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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