Opportunity Information: Apply for PA 07 374
Apply for PA 07 374
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Psychopharmacology of Widely Available Psychoactive Natural Products (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 4, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Independent school districts Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Psychopharmacology of Widely Available Psychoactive Natural Products (R01) funding opportunity (PA-07-374) is a National Institutes of Health (NIH) research grant solicitation aimed at improving scientific understanding of psychoactive natural products that are readily accessible to the public. The central focus is on generating rigorous data about what these products contain (chemistry), how they act in the body and brain (psychopharmacology), and what harms they may cause (toxicology), particularly under conditions of both acute use (short-term exposure) and chronic use (long-term, repeated exposure). A key theme running through the announcement is the public health relevance of these products, including how their use may progress or "transition" into the use of licit (legally available) or illicit drugs of abuse, which ties the topic directly to drug abuse and addiction research priorities.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is designed to support discrete, hypothesis-driven research projects of substantial scope. The announcement notes that it is scientifically parallel to another NIH posting, PA-07-375, that supports the same general research topics but under the R03 mechanism, which is typically used for smaller, shorter, or more exploratory studies. In practical terms, applicants whose projects require the scale, duration, and resources typical of a full research program would align with the R01 route described here, while smaller pilot-style projects might fit better under the companion R03 opportunity.
In terms of what the NIH is looking to fund, the announcement emphasizes studies that characterize the chemical composition of psychoactive natural products and connect that chemistry to biological and behavioral effects. This can include identifying active constituents, understanding variability in product composition, and linking specific compounds or mixtures to pharmacological effects and toxic outcomes. The psychopharmacology component points to work that clarifies mechanisms of action, dose-response relationships, and effects on neurobiological systems relevant to reinforcement, cognition, mood, and other domains commonly impacted by psychoactive substances. The toxicology component highlights both immediate adverse effects and longer-term consequences of sustained exposure, including potential organ toxicity, neurotoxicity, and other clinically meaningful harms. Another explicitly named research direction is studying patterns and mechanisms that may underlie escalation from use of these natural products to other substances, including legally available drugs (for example, prescription or over-the-counter products) and illegal drugs, with attention to abuse liability and trajectories of use.
Awards under this FOA are described as contingent on the availability of funds and the number of high-quality applications received, and the announcement does not promise a set number of awards. Instead, it indicates that NIH will make awards based on merit and funding availability, consistent with typical NIH grant processes. The posting lists multiple receipt dates, meaning applications are accepted on recurring submission cycles rather than a single one-time deadline, and applicants are directed to the full announcement for the specific dates and detailed instructions.
Eligibility is broad and includes a wide range of organization types across the public, private, nonprofit, and for-profit sectors. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, and other for-profit organizations (excluding small businesses only where specified in the eligibility list), along with state, county, city/township, and special district governments. The eligibility list also includes independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. Importantly, the announcement specifies that foreign institutions are eligible to apply, and that eligible federal agencies may apply as well. Faith-based and community-based organizations are also explicitly included as eligible applicants. The opportunity states there is no cost sharing or matching requirement, so applicants are not required to provide matching funds as a condition of award.
Administratively, the opportunity is categorized as a discretionary grant, with NIH as the sponsoring agency, and it is associated with program areas including Environmental Health (CFDA 93.113) and Drug Abuse and Addiction Research Programs (CFDA 93.279). The original posting date is June 4, 2007, with archival information indicating the announcement was later archived (archive date October 8, 2010), which typically means it is no longer active in its original form; however, the summary provided reflects what the NIH sought to support under this specific FOA during its active period. For full details, the announcement provides an NIH grants guide link and contact instructions through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name and identifier of this grant opportunity?
This funding opportunity is titled "The Psychopharmacology of Widely Available Psychoactive Natural Products (R01)" and is identified as PA-07-374.
Which agency is offering this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism does this use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which supports discrete, hypothesis-driven research projects of substantial scope.
What is the overall purpose of this FOA?
The purpose is to improve scientific understanding of psychoactive natural products that are readily accessible to the public by generating rigorous data about what these products contain (chemistry), how they act in the body and brain (psychopharmacology), and what harms they may cause (toxicology) under both acute and chronic use conditions.
What kinds of products does the FOA focus on?
The FOA focuses on psychoactive natural products that are widely available and readily accessible to the public.
What scientific topics and disciplines are emphasized?
The announcement emphasizes three connected areas: (1) chemistry/composition of products, (2) psychopharmacology (actions in the body and brain), and (3) toxicology (harms and adverse outcomes).
What does the FOA mean by studying the "chemistry" of these products?
Chemistry work includes characterizing chemical composition, identifying active constituents, understanding variability in product composition, and connecting specific compounds or mixtures to pharmacological and toxic outcomes.
What does the FOA mean by studying "psychopharmacology"?
Psychopharmacology studies are described as work that clarifies mechanisms of action, dose-response relationships, and effects on neurobiological systems relevant to reinforcement, cognition, mood, and other domains commonly affected by psychoactive substances.
What does the FOA mean by studying "toxicology"?
Toxicology work includes evaluating immediate adverse effects as well as longer-term consequences of sustained exposure, including potential organ toxicity, neurotoxicity, and other clinically meaningful harms.
Does the FOA cover both short-term and long-term exposure?
Yes. The FOA explicitly highlights both acute use (short-term exposure) and chronic use (long-term, repeated exposure).
How does public health relevance factor into this opportunity?
Public health relevance is a central theme. The FOA connects these natural products to broader public health concerns, including potential harms and patterns of use that may lead to more problematic substance use.
Does the FOA include research on progression from natural products to other drugs?
Yes. An explicitly named direction is studying patterns and mechanisms that may underlie escalation or "transition" from using these natural products to using other substances, including licit drugs (such as prescription or over-the-counter products) and illicit drugs, with attention to abuse liability and trajectories of use.
Is there a related or companion funding opportunity?
Yes. The FOA notes it is scientifically parallel to PA-07-375, which supports the same general research topics using the R03 mechanism.
How is PA-07-375 (R03) different from this R01 FOA?
Based on the description provided, the R01 is positioned for projects needing the scale, duration, and resources typical of a full research program, while the companion R03 is described as typically used for smaller, shorter, or more exploratory studies.
Does the FOA guarantee a certain number of awards?
No. Awards are described as contingent on the availability of funds and the number of high-quality applications received, and the FOA does not promise a set number of awards.
How does NIH decide whether to make awards under this opportunity?
The FOA indicates awards will be made based on merit and funding availability, consistent with typical NIH grant processes.
Are there recurring application deadlines or a single due date?
The posting lists multiple receipt dates, meaning applications are accepted on recurring submission cycles rather than a single one-time deadline. Applicants are directed to the full announcement for the specific dates.
Who is eligible to apply?
Eligibility is broad and includes many organization types across public, private, nonprofit, and for-profit sectors, as well as various levels of government and tribal entities.
Are U.S. institutions of higher education eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Nonprofits are eligible, including those with and without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. The eligibility list includes small businesses and other for-profit organizations.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly included as eligible applicants.
Are foreign institutions eligible to apply?
Yes. The announcement specifies that foreign institutions are eligible to apply.
Can government entities apply?
Yes. The eligibility list includes state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are Native American tribal governments and organizations eligible?
Yes. The eligibility list includes Native American tribal governments and Native American tribal organizations.
Can federal agencies apply?
Yes. The announcement specifies that eligible federal agencies may apply.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
How is this opportunity categorized administratively?
It is categorized as a discretionary grant, with NIH as the sponsoring agency.
Which program areas or CFDA numbers are associated with this FOA?
The opportunity is associated with Environmental Health (CFDA 93.113) and Drug Abuse and Addiction Research Programs (CFDA 93.279).
When was the FOA originally posted?
The original posting date listed is June 4, 2007.
Is this FOA still active?
The archival information indicates the announcement was archived on October 8, 2010, which typically means it is no longer active in its original form.
Where are applicants directed for full details and official instructions?
Applicants are directed to the full announcement (NIH grants guide link) for specific receipt dates and detailed instructions.
Who is listed as a point of contact for access or linking issues?
The announcement references contact instructions through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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| Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) Apply for PA 07 375 Funding Number: PA 07 375 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Predictive Multiscale Models of the Physiome in Health and Disease (R01) Apply for PAR 08 023 Funding Number: PAR 08 023 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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| Nanoscience and Nanotechnology in Biology and Medicine (R21) Apply for PA 08 053 Funding Number: PA 08 053 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
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| Exploratory Collaborations with National Centers for Biomedical Computing (R21) Apply for PAR 08 183 Funding Number: PAR 08 183 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
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| Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42) Apply for PAR 07 161 Funding Number: PAR 07 161 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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| Innovations in Biomedical Computational Science and Technology (R01) Apply for PAR 09 218 Funding Number: PAR 09 218 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
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| Enabling Technologies in DNA Repair Research (R21) Apply for PAR 10 016 Funding Number: PAR 10 016 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
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