Opportunity Information: Apply for PA 07 375
Apply for PA 07 375
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Psychopharmacology Of Widely Available Psychoactive Natural Products (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 4, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education State governments Small businesses Special district governments Native American tribal governments (Federally recognized) Private institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) funding opportunity (PA-07-375) is a National Institutes of Health (NIH) small grant program designed to support early-stage or narrowly focused research on psychoactive natural products that are readily available and may be used for their mind-altering effects. The core aim is to generate scientific evidence about what these products contain (their chemistry), how they act in the body and brain (psychopharmacology), and what harms they may cause (toxicology), looking at both short-term (acute) exposure and longer-term (chronic) use. A key public health angle is the interest in understanding how use of these natural products can shift over time into misuse of regulated substances, including transitions to licit medications used nonmedically or to illicit drugs of abuse.
This announcement uses the NIH Small Research Grant (R03) mechanism, which is typically intended for smaller, self-contained projects that can be completed with limited funding and within a shorter scope than larger NIH awards. The R03 format is commonly used for pilot and feasibility studies that help establish whether a research direction is workable, for developing or refining research methods and technologies, and for secondary analyses of existing datasets where investigators can answer important questions without launching a large new study. The FOA also notes that it runs in parallel with a scientifically identical R01 opportunity (PA-07-374), meaning the scientific topics are aligned, but the R03 is meant for a smaller scale of work than an R01.
In terms of what NIH is looking for scientifically, the emphasis is on rigorous characterization and mechanistic understanding. On the chemistry side, that can include identifying active constituents, variability in composition across sources or preparations, contaminants or adulterants, and how processing or dosing affects exposure. On the psychopharmacology side, relevant work may involve how these compounds interact with receptor systems, alter neurotransmission, influence behavior or cognition, and produce reinforcing or aversive effects that could relate to abuse liability. On the toxicology side, the FOA highlights both acute and chronic effects, which could include organ toxicity, neurotoxicity, interactions with other substances, dose-response relationships, and factors that increase risk such as repeated use patterns or high-potency preparations. The transition component broadens the scope beyond basic characterization by encouraging research that helps explain pathways from initial use of natural psychoactive products to later misuse of controlled or prescription substances, which is particularly relevant when products are marketed as legal or harmless alternatives.
Administratively, this is a discretionary grant opportunity offered by NIH and is associated with program areas reflected in CFDA numbers 93.113 (Environmental Health) and 93.279 (Drug Abuse and Addiction Research Programs), indicating relevance to both exposure-related health concerns and substance use/addiction research. There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds to be eligible. The opportunity listed multiple receipt dates rather than a single deadline, so applications were accepted on recurring cycles during the active period of the announcement.
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit entities (other than small businesses), state, county, city, and special district governments, independent school districts, public housing authorities, and tribal governments and tribal organizations. The announcement explicitly states that foreign institutions are eligible to apply, and that eligible federal agencies can apply as well. Faith-based and community-based organizations are also included as eligible applicants, which signals NIH’s intent to allow a wide range of institutional settings to pursue this research when they have appropriate expertise and infrastructure.
For applicants needing more detail, NIH provided an official full announcement link and support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues. Overall, the program is best understood as a targeted, small-grant pathway to build credible, publishable evidence about the contents, biological effects, and potential public health risks of commonly accessible psychoactive natural products, including how their use may relate to later substance abuse patterns.
Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is titled The Psychopharmacology Of Widely Available Psychoactive Natural Products (R03) and is identified as PA-07-375.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) funding opportunity.
What type of grant mechanism is used?
The announcement uses the NIH Small Research Grant (R03) mechanism, which is intended for smaller, self-contained projects with a limited scope compared to larger NIH awards.
What is the main purpose of this R03 program?
The core aim is to generate scientific evidence about widely available psychoactive natural products, including:
- What these products contain (chemistry)
- How they act in the body and brain (psychopharmacology)
- What harms they may cause (toxicology), including both acute and chronic effects
What kinds of products are the focus of this opportunity?
The focus is on psychoactive natural products that are readily available and may be used for their mind-altering effects.
What research topics are emphasized on the chemistry side?
Example chemistry-focused topics described in the announcement include:
- Identifying active constituents
- Studying variability in composition across sources or preparations
- Detecting contaminants or adulterants
- Assessing how processing or dosing affects exposure
What research topics are emphasized on the psychopharmacology side?
Example psychopharmacology topics described include:
- How compounds interact with receptor systems
- How they alter neurotransmission
- How they influence behavior or cognition
- Whether they produce reinforcing or aversive effects relevant to abuse liability
What research topics are emphasized on the toxicology side?
The FOA highlights both acute and chronic effects. Example toxicology topics described include:
- Organ toxicity
- Neurotoxicity
- Interactions with other substances
- Dose-response relationships
- Risk factors such as repeated use patterns or high-potency preparations
Does the opportunity consider short-term and long-term exposure?
Yes. The announcement explicitly notes interest in both short-term (acute) exposure and longer-term (chronic) use.
Is there a public health angle to this program?
Yes. A key public health component is understanding how use of these natural products may shift over time into misuse of regulated substances, including transitions to:
- Licit medications used nonmedically
- Illicit drugs of abuse
What does the announcement mean by the "transition" component?
It encourages research that helps explain pathways from initial use of psychoactive natural products (often marketed as legal or harmless alternatives) to later misuse of controlled substances or prescription medications.
How is an R03 project typically described in this opportunity?
The R03 is described as suitable for smaller, narrowly focused efforts such as:
- Pilot and feasibility studies
- Developing or refining research methods and technologies
- Secondary analyses of existing datasets
Is there a related R01 opportunity?
Yes. The R03 FOA runs in parallel with a scientifically identical R01 opportunity, PA-07-374. The scientific topics align, but the R03 is intended for a smaller scale of work than an R01.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What CFDA program areas are associated with this opportunity?
The FOA is associated with CFDA numbers:
- 93.113 (Environmental Health)
- 93.279 (Drug Abuse and Addiction Research Programs)
Who is eligible to apply?
Eligibility is described as broad and includes many types of U.S. organizations, including:
- Public and private institutions of higher education
- Nonprofits (with and without 501(c)(3) status)
- Small businesses
- For-profit entities (other than small businesses)
- State, county, city, and special district governments
- Independent school districts
- Public housing authorities
- Tribal governments and tribal organizations
- Faith-based and community-based organizations
Are foreign institutions eligible to apply?
Yes. The announcement explicitly states that foreign institutions are eligible.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies can apply.
Is there a single application deadline?
No. The opportunity listed multiple receipt dates rather than a single deadline, meaning applications were accepted on recurring cycles during the active period of the announcement.
Where can applicants find the official full announcement?
NIH provided an official full announcement link in the opportunity information for applicants who need more detail.
Who should be contacted for access or linking issues related to the announcement?
The opportunity references support contacts through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
What is the overall goal of the program in plain terms?
Overall, it is a targeted small-grant pathway to build credible, publishable evidence about the contents, biological effects, and potential public health risks of commonly accessible psychoactive natural products, including how their use may relate to later substance misuse patterns.
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