Opportunity Information: Apply for RFA HL 14 027
Apply for RFA HL 14 027
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics Clinical Centers (CC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Nov 25, 2013 and posted on Nov 25, 2013.
- Applicants must submit their applications by Jan 29, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Independent school districts For profit organizations other than small businesses Private institutions of higher education City or township governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
This funding opportunity, issued by the National Institutes of Health through the National Heart, Lung, and Blood Institute (NHLBI), supports participation in a coordinated research effort called the Pulmonary Vascular Disease Phenomics Program (PVDOMICS). The central goal is to rethink how pulmonary hypertension (PH) is defined and classified by using modern, comprehensive "deep phenotyping" approaches across all five World Health Organization (WHO) PH clinical groups (Groups 1 through 5). Rather than focusing on one narrow subtype, the program is designed to capture detailed clinical, biological, and physiological profiles spanning the full spectrum of PH, with the broader intent of improving how patients are categorized and, ultimately, how disease mechanisms and treatment targets are understood.
The award mechanism is a U01 cooperative agreement, which means it is not a typical investigator-initiated grant with minimal federal involvement. Instead, it is meant to function as a collaborative network in which NIH/NHLBI staff have substantial scientific and programmatic involvement. Applicants are expected to operate as part of a structured, multi-site consortium where participating teams align their protocols, contribute standardized data and samples, and follow common procedures to make the combined dataset meaningful at a national program level. In practice, this kind of structure is meant to accelerate discovery by ensuring that each clinical site contributes comparable, high-quality phenotyping data that can be integrated across the network.
The overall PVDOMICS program is planned to include up to five Clinical Centers (CCs) plus a separate Data Coordinating Center (DCC). This specific announcement (RFA-HL-14-027) solicits applications only for the Clinical Centers. A separate, parallel funding opportunity (RFA-HL-14-030) covers the DCC, which would typically be responsible for central data management, coordination, quality control, harmonization of measures, and cross-site analytics support. The Clinical Centers, in turn, are expected to be the primary hubs for patient recruitment/assessment and for executing the deep phenotyping protocols that generate the clinical and research data feeding into the shared program infrastructure.
From an administrative standpoint, the opportunity is categorized as discretionary funding and sits under the health research activity area. The CFDA listing is 93.838 (Lung Diseases Research). The announcement was posted on November 25, 2013, created the same day, and had an original and current closing date of January 29, 2014, with an archive date of March 1, 2014. The listed award ceiling is $200,000, and there is no cost sharing or matching requirement, meaning applicants were not required to provide non-federal matching funds as a condition of the award.
Eligibility is broad and includes many types of organizations. U.S.-based eligible applicants include state, county, city/township, and special district governments; federally recognized and other tribal governments and tribal organizations; public and private institutions of higher education; nonprofits with or without 501(c)(3) status (with distinctions made for those that are not institutions of higher education); public housing authorities/Indian housing authorities; independent school districts; small businesses; and certain for-profit entities other than small businesses. The announcement also explicitly expands eligibility to a range of institution types and community-serving organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations and eligible federal agencies.
Notably, non-U.S. entities are also eligible. Foreign organizations and foreign institutions can apply, and non-U.S. components of U.S. organizations are eligible as well. In addition, foreign components, as defined under the NIH Grants Policy Statement, are allowed. This signals that NHLBI was open to incorporating international expertise or patient populations, provided the proposed work aligns with program requirements and can integrate with the consortium model and its data standards.
In terms of what applicants were being asked to do, the key deliverable is participation in a networked, standardized effort to perform deep phenotyping across WHO PH Groups 1 to 5. While the short synopsis does not list specific required assays or measures, the phrase "comprehensive, deep phenotyping" in an NHLBI consortium context typically implies collecting harmonized clinical data and detailed characterization that may include imaging, hemodynamics, functional measures, biomarkers, biospecimens, and other multidimensional data types that can support phenomics-style analyses. The intent is to move beyond existing clinical labels and generate richer, cross-cutting phenotypic patterns that could redefine disease subtypes based on biology and measurable traits rather than only traditional clinical categories.
For anyone needing the official announcement text, the funding notice is linked at http://grants.nih.gov/grants/guide/rfa_files/RFA_HL_14_027.html. Technical issues accessing the announcement were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is the contact listed for access and linking problems rather than a scientific/program contact in the excerpt provided.
FAQs: NIH/NHLBI Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Clinical Centers (RFA-HL-14-027)
1) What is this funding opportunity about?
This opportunity, issued by the National Institutes of Health (NIH) through the National Heart, Lung, and Blood Institute (NHLBI), supports participation in the Pulmonary Vascular Disease Phenomics Program (PVDOMICS). The program is a coordinated research effort focused on pulmonary hypertension (PH) and is designed to generate comprehensive, standardized patient profiles using modern "deep phenotyping" approaches.
2) What is the main goal of the PVDOMICS program?
The central goal is to rethink how pulmonary hypertension is defined and classified. Instead of relying only on traditional clinical categories, PVDOMICS aims to use rich clinical, biological, and physiological data to identify patterns that could improve patient categorization and help clarify disease mechanisms and treatment targets.
3) Which pulmonary hypertension (PH) groups are included?
The program spans all five World Health Organization (WHO) pulmonary hypertension clinical groups (Groups 1 through 5). A key feature is that it is not limited to a single PH subtype; it is intended to capture the full spectrum of PH.
4) What does "deep phenotyping" mean in this context?
Based on the opportunity description, deep phenotyping refers to collecting modern, comprehensive, and multidimensional patient characterization data across clinical, biological, and physiological domains. While the excerpt does not list specific required tests, it emphasizes generating detailed standardized profiles suitable for phenomics-style analysis across participating sites.
5) What is the award mechanism and what does it imply?
The mechanism is a U01 cooperative agreement. This means the project is not structured as a typical investigator-initiated grant with minimal federal involvement. Instead, NIH/NHLBI staff are expected to have substantial scientific and programmatic involvement, and awardees are expected to operate as part of a coordinated consortium.
6) What does participating in a consortium involve for applicants?
Applicants are expected to function within a structured, multi-site network. This includes aligning protocols, contributing standardized data and samples, and following common procedures so that data can be meaningfully combined across sites at the national program level.
7) Is this announcement for Clinical Centers or for the Data Coordinating Center?
This announcement (RFA-HL-14-027) solicits applications only for the Clinical Centers (CCs). A separate, parallel funding opportunity covers the Data Coordinating Center (DCC) under RFA-HL-14-030.
8) How many awards or sites were planned under PVDOMICS?
The overall program was planned to include up to five Clinical Centers (CCs), plus a separate Data Coordinating Center (DCC).
9) What are Clinical Centers expected to do?
Clinical Centers are expected to serve as primary hubs for patient recruitment and assessment and for executing the deep phenotyping protocols. The resulting clinical and research data are intended to feed into shared program infrastructure to support integrated analysis across the consortium.
10) What is the role of the Data Coordinating Center (DCC) (even though it is not covered by this RFA)?
As described, the DCC would typically handle central data management and coordination functions such as quality control, harmonization of measures, and cross-site analytics support. The DCC is competed under a separate announcement (RFA-HL-14-030).
11) What is the maximum award amount listed?
The listed award ceiling is $200,000.
12) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants were not required to provide non-federal matching funds as a condition of the award.
13) What is the CFDA number and program area?
The CFDA listing is 93.838, identified as Lung Diseases Research. The opportunity is categorized under the health research activity area.
14) What type of funding is this categorized as?
It is categorized as discretionary funding.
15) Who is eligible to apply (U.S.-based organizations)?
Eligibility is broad and includes U.S.-based state, county, city/township, and special district governments; federally recognized and other tribal governments and tribal organizations; public and private institutions of higher education; nonprofits with or without 501(c)(3) status (with distinctions for those not considered institutions of higher education); public housing authorities/Indian housing authorities; independent school districts; small businesses; and certain for-profit entities other than small businesses.
16) Are specific institution types and community-serving organizations included?
Yes. The announcement explicitly includes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also includes faith-based and community-based organizations and eligible federal agencies.
17) Can foreign (non-U.S.) organizations apply?
Yes. The announcement notes that foreign organizations and foreign institutions are eligible to apply. Non-U.S. components of U.S. organizations are also eligible, and foreign components (as defined under the NIH Grants Policy Statement) are allowed.
18) Does allowing foreign components mean international participation is expected?
The text indicates NHLBI was open to incorporating international expertise or patient populations, as long as the proposed work aligns with program requirements and can integrate with the consortium model and its data standards.
19) What is the key deliverable expected from awardees?
The key deliverable is active participation in a networked, standardized effort to perform comprehensive deep phenotyping across WHO PH Groups 1 through 5 and contribute standardized data (and, as implied by consortium language, samples) in alignment with common procedures.
20) Where can applicants find the official funding announcement?
The official announcement is linked here: http://grants.nih.gov/grants/guide/rfa_files/RFA_HL_14_027.html
21) What are the posted dates and deadlines for this opportunity?
The announcement was posted on November 25, 2013, and created the same day. The original and current closing date is January 29, 2014. The archive date is March 1, 2014.
22) Who is listed as the contact for technical issues accessing the announcement?
Technical issues accessing the announcement were directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. This contact is specifically for access and linking problems rather than a scientific or programmatic contact (based on the excerpt provided).
Browse more opportunities from the same category: Health
Next opportunity: BLM CA Modoc County Weed Management Area Surprise Field Office
Previous opportunity: Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics Data Coordinating Center (DCC) (U01)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HL 14 027
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 14 027) also looked into and applied for these:
| Funding Opportunity |
|---|
| Indoor Environment of Low Income Renovated Multifamily Housing in the United States (U01) Apply for RFA EH 14 001 Funding Number: RFA EH 14 001 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Increasing Participation of People with Disabilities in USAID Activities and Strengthen the Capacities of Disabled Peoples Organizations (DPOs). Apply for RFA 114 14 000001 Funding Number: RFA 114 14 000001 Agency: Georgia USAID Tbilisi Category: Health Funding Amount: $600,000 |
| Deliberative Approaches Patient and Consumer Input for Implementing Evidence Based Health Care (R21) Apply for RFA HS 14 007 Funding Number: RFA HS 14 007 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $200,000 |
| International Collaborations in Infectious Diseases Research (U01) Apply for RFA AI 14 001 Funding Number: RFA AI 14 001 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| International Collaborations in Infectious Diseases Research (U19) Apply for RFA AI 14 002 Funding Number: RFA AI 14 002 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Announcement of the Anticipated Availability of Funds for Research on Research Integrity Apply for IR ORI 14 001 Funding Number: IR ORI 14 001 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: $150,000 |
| Nurse Education, Practice, Quality and Retention (NEPQR) Program Interprofessional Collaborative Practice Apply for HRSA 14 070 Funding Number: HRSA 14 070 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Nursing Workforce Diversity (NWD) Program Apply for HRSA 14 069 Funding Number: HRSA 14 069 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Strengthening Public Health Systems in the Caribbean Region by supporting the Caribbean Public Health Agency (CARPHA) under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH14 1404 Funding Number: CDC RFA GH14 1404 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,000,000 |
| Service Area Competition Additional Area (SAC AA) AK, MA, MS, and NC Apply for HRSA 14 114 Funding Number: HRSA 14 114 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Center for Advancing Natural Products Innovation and Technology (U41) Apply for RFA AT 14 006 Funding Number: RFA AT 14 006 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
| Botanical Dietary Supplement Research Centers (P50) Apply for RFA OD 14 001 Funding Number: RFA OD 14 001 Agency: National Institutes of Health Category: Health Funding Amount: $1,250,000 |
| Advanced Nursing Education Program Apply for HRSA 14 066 Funding Number: HRSA 14 066 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Healthy Start Initiative Eliminating Disparities in Perinatal Health Apply for HRSA 14 020 Funding Number: HRSA 14 020 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Healthy Start Initiative Eliminating Disparities in Perinatal Health Apply for HRSA 14 112 Funding Number: HRSA 14 112 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Healthy Start Initiative Eliminating Disparities in Perinatal Health Apply for HRSA 14 113 Funding Number: HRSA 14 113 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Support of Competitive Research (SCORE) Research Advancement Award (SC1) Apply for PAR 14 019 Funding Number: PAR 14 019 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Support of Competitive Research (SCORE) Pilot Project Award (SC2) Apply for PAR 14 017 Funding Number: PAR 14 017 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Support of Competitive Research (SCORE) Research Continuance Award (SC3) Apply for PAR 14 018 Funding Number: PAR 14 018 Agency: National Institutes of Health Category: Health Funding Amount: $75,000 |
| Advanced Education Nursing Traineeship (AENT) Program Apply for HRSA 14 067 Funding Number: HRSA 14 067 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HL 14 027", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.