Opportunity Information: Apply for RFA HL 14 030
Apply for RFA HL 14 030
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics Data Coordinating Center (DCC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Nov 25, 2013 and posted on Nov 25, 2013.
- Applicants must submit their applications by Jan 29, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Small businesses For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This funding opportunity (RFA-HL-14-030) is a National Heart, Lung, and Blood Institute (NHLBI) cooperative agreement (U01) to support a Data Coordinating Center (DCC) for a larger research effort called the Pulmonary Vascular Disease Phenomics Program, or PVDOMICS. The overall program is built around the idea that pulmonary hypertension (PH), as it is currently categorized into World Health Organization (WHO) Groups 1 through 5, likely contains multiple biologically distinct subtypes that are not fully captured by the existing clinical classifications. PVDOMICS is designed to rethink those categories by collecting and integrating very detailed patient data (often described as "deep phenotyping") so investigators can identify new, mechanism-based subclasses of pulmonary vascular and right ventricular disease.
The scientific goal behind the program is to link clinical presentation to underlying biology. Across WHO PH Groups 1-5, participating clinical teams will gather comprehensive molecular, imaging (radiographic), physiologic, and clinical measurements using a shared, common phenotyping protocol. By analyzing these multi-dimensional data together, the program aims to define endophenotypes (measurable subtypes that sit between genes/biology and outward disease) and to discover biomarkers that could help with earlier diagnosis, improved risk stratification, or objective measurement of response to therapies and preventive interventions. In practice, this means moving from broad labels to more precise, data-driven groupings that can be tied to specific pathways of disease development and progression.
This particular FOA focuses on the infrastructure and leadership needed to make that kind of multi-site phenomics effort work: the Data Coordinating Center. The DCC is meant to serve as the hub for data operations across the program, running in parallel with a separate FOA for the Clinical Centers (RFA-HL-14-027) that would recruit and phenotype participants. While the announcement text provided here is abbreviated, the DCC role in efforts like PVDOMICS typically includes building and managing the study database; developing data standards, formats, and common data elements; ensuring consistent data collection across sites; overseeing data quality control and query resolution; managing secure data transfer and storage; supporting protocol-driven workflows; and coordinating analytic plans so that molecular, imaging, and clinical data can be integrated. Because this is a cooperative agreement, the DCC would be expected to work closely with NHLBI staff and with the funded clinical sites in a coordinated governance structure, rather than operating as a fully independent, investigator-initiated project.
From an administrative standpoint, the opportunity is discretionary funding from NIH/NHLBI under the Lung Diseases Research CFDA (93.838), with no cost sharing or matching requirement. The award ceiling listed is $275,000 (as presented in the source summary). The FOA was posted November 25, 2013, and closed January 29, 2014, with an archive date of March 1, 2014, meaning it is not currently open but serves as a record of the program solicitation.
Eligibility is broad and includes many types of domestic U.S. organizations: public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), small businesses and other for-profit entities, state and local governments (including counties, cities/townships, special districts), independent school districts, public housing authorities, and tribal governments and organizations. The eligibility language also explicitly calls out several institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based and community-based organizations and eligible federal agencies. At the same time, it clearly restricts foreign involvement: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
In short, RFA-HL-14-030 was a targeted call to fund the central coordinating and data management engine for a multi-center NHLBI program aimed at redefining pulmonary hypertension through integrated, high-resolution phenotyping. The DCC was intended to make it possible to harmonize and analyze complex data across multiple clinical sites, with the long-term payoff being more biologically meaningful PH subtypes, clearer disease mechanisms, and practical biomarkers to improve diagnosis and treatment evaluation.
Frequently Asked Questions (FAQs)
What is RFA-HL-14-030?
RFA-HL-14-030 is an NIH/National Heart, Lung, and Blood Institute (NHLBI) funding opportunity announcement for a cooperative agreement (U01) to support a Data Coordinating Center (DCC) for the Pulmonary Vascular Disease Phenomics Program (PVDOMICS).
What is PVDOMICS?
PVDOMICS stands for the Pulmonary Vascular Disease Phenomics Program. It is a larger NHLBI research effort designed to collect and integrate highly detailed patient data ("deep phenotyping") to improve how pulmonary hypertension (PH) is categorized and understood.
What problem is PVDOMICS trying to solve in pulmonary hypertension?
PVDOMICS is based on the idea that pulmonary hypertension, as currently divided into World Health Organization (WHO) Groups 1 through 5, likely contains multiple biologically distinct subtypes that are not fully captured by existing clinical classifications.
What is the scientific goal of the PVDOMICS program?
The scientific goal is to link clinical presentation to underlying biology by collecting comprehensive molecular, imaging (radiographic), physiologic, and clinical measurements across WHO PH Groups 1-5 using a shared phenotyping protocol, then integrating and analyzing those multi-dimensional data together.
What are "endophenotypes" in the context of this program?
In this program, endophenotypes are measurable subtypes that sit between genes/biology and outward disease. PVDOMICS aims to define these endophenotypes by integrating deep phenotyping data across participants.
What kinds of discoveries is PVDOMICS aiming for?
PVDOMICS aims to discover biomarkers and define mechanism-based subclasses of pulmonary vascular and right ventricular disease that could support earlier diagnosis, improved risk stratification, and objective measurement of response to therapies and preventive interventions.
What does this specific FOA fund?
This FOA funds the infrastructure and leadership for the Data Coordinating Center (DCC), which serves as the hub for data operations across the PVDOMICS program.
How does the Data Coordinating Center (DCC) fit into the overall program structure?
The DCC runs in parallel with a separate FOA for Clinical Centers (RFA-HL-14-027). Clinical Centers would recruit and phenotype participants, while the DCC would coordinate and manage the program's data operations and cross-site data integration.
What are typical responsibilities of the DCC for an effort like PVDOMICS?
Based on the description provided, typical DCC responsibilities include building and managing the study database; developing data standards, formats, and common data elements; ensuring consistent data collection across sites; overseeing data quality control and query resolution; managing secure data transfer and storage; supporting protocol-driven workflows; and coordinating analytic plans to integrate molecular, imaging, and clinical data.
What does it mean that this award is a cooperative agreement (U01)?
A cooperative agreement indicates that the DCC would be expected to work closely with NHLBI staff and funded clinical sites in a coordinated governance structure, rather than operating as a fully independent, investigator-initiated project.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH).
What is the CFDA listing associated with this opportunity?
The opportunity is listed under the Lung Diseases Research CFDA number 93.838.
Is there a cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement.
What is the award ceiling for this FOA?
The award ceiling listed in the provided summary is $275,000.
When was the FOA posted, and is it still open?
The FOA was posted on November 25, 2013, and closed on January 29, 2014. It has an archive date of March 1, 2014, so it is not currently open.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. organizations, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), small businesses and other for-profit entities, state and local governments (including counties, cities/townships, special districts), independent school districts, public housing authorities, tribal governments and organizations, and eligible federal agencies.
Are specific institution types explicitly mentioned as eligible?
Yes. The eligibility language explicitly calls out institution types including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based and community-based organizations.
Are foreign organizations eligible to apply?
No. Non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply.
Can a U.S. organization apply if it has a non-domestic component?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this FOA?
No. Foreign components, as defined by NIH policy, are not allowed.
Does this FOA fund the clinical recruitment and phenotyping sites directly?
No. This FOA is focused on the Data Coordinating Center (DCC). A separate FOA (RFA-HL-14-027) addresses the Clinical Centers that would recruit and phenotype participants.
What is the long-term intended payoff of funding a DCC for PVDOMICS?
The intended long-term payoff is to enable harmonized, high-quality, multi-site data integration and analysis that can support more biologically meaningful PH subtypes, clearer disease mechanisms, and practical biomarkers to improve diagnosis and evaluation of treatment responses.
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