Opportunity Information: Apply for PA 08 241

  • The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Reducing Risk Behaviors by Promoting Positive Youth Development (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Aug 15, 2008.
  • Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments County governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
Apply for PA 08 241

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Opportunity Summary:

The National Institutes of Health (NIH) grant opportunity titled "Reducing Risk Behaviors by Promoting Positive Youth Development (R01)" (Funding Opportunity Number PA-08-241) supports research that builds stronger evidence around positive youth development (PYD) approaches and how they lead to healthier developmental outcomes for adolescents and youth. The central aim is not simply to document whether a program works, but to improve understanding of the specific program features and underlying mechanisms that drive positive change, including reductions in health-risk behaviors. In practical terms, NIH is looking for research that can explain how and why PYD strategies help young people thrive, and how those strategies can be strengthened, tested, and brought effectively to different groups of youth.

This announcement invites Research Project Grant (R01) applications proposing rigorous development, implementation, and evaluation of new or enhanced PYD programs, as well as careful evaluation of programs that have already demonstrated success. It also encourages work focused on evidence-based, gender-inclusive programs that are adapted or translated for new settings or populations, or disseminated more broadly. That emphasis on adaptation and dissemination signals interest in real-world impact: applicants can propose studies that examine what it takes to maintain effectiveness when a proven program is modified for cultural relevance, delivered in a different community context, or scaled beyond its original environment. Across these approaches, the opportunity prioritizes research that links PYD program components to measurable improvements in health and developmental trajectories.

The funding mechanism is the NIH Research Project Grant (R01), which is the standard NIH mechanism for supporting substantial, multi-year research projects. This announcement runs in parallel with a separate funding opportunity of the same scientific scope that uses the R03 mechanism (PA-08-242), which typically supports smaller, more limited projects. For this R01 version, the expectation is that proposed studies will have the scope, design, and analytic plan appropriate for a full-scale research project, including strong evaluation methods and clear articulation of the pathways through which PYD programs are expected to influence outcomes.

Funding availability and the number of awards are not fixed in advance. Awards under PA-08-241 are contingent on NIH having funds available and receiving a sufficient number of high-quality, competitive applications. This means the program does not guarantee a specific count of awards; instead, funding decisions will depend on the overall merit of submissions and the budget environment at the time of review and award.

The opportunity is categorized as a discretionary grant and spans several public health and human development domains reflected in the listed CFDA numbers, including alcohol research (93.273), drug abuse and addiction research (93.279), nursing research (93.361), cancer cause and prevention research (93.393), and child health and human development extramural research (93.865). This range suggests the research supported can address multiple, intersecting outcomes and risk areas affecting adolescents, from substance use and sexual health to broader developmental health and prevention-related endpoints, as long as the work is grounded in positive youth development frameworks and produces evidence relevant to reducing risk behaviors and improving well-being.

Eligibility is broad and includes many types of U.S. and non-U.S. entities. Eligible applicants listed include for-profit organizations (including small businesses), nonprofit organizations (including those with and without 501(c)(3) status), institutions of higher education (public and private), and multiple levels of government (state, county, city/township, special district), as well as independent school districts and public/Indian housing authorities. The announcement also explicitly includes a range of mission-focused and underserved-serving institutions and entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments and tribal organizations, U.S. territories or possessions, regional organizations, and foreign (non-U.S.) organizations. There is no cost-sharing or matching requirement, which can make participation more feasible for organizations that cannot commit non-federal matching funds.

Key administrative details include a posted date of August 15, 2008, with the original and current closing date listed as September 7, 2011, and an archive date of October 8, 2011, indicating the opportunity is no longer open for new submissions under that specific announcement. The full announcement was made available through the NIH grants guide at the provided link, and NIH Office of Extramural Research (OER) contact points are provided for technical access or linking issues.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this NIH grant?

The opportunity is titled "Reducing Risk Behaviors by Promoting Positive Youth Development (R01)" and the Funding Opportunity Number is PA-08-241.

What is the main purpose of this funding opportunity?

This NIH opportunity supports research to strengthen the evidence base for positive youth development (PYD) approaches and to explain how those approaches lead to healthier developmental outcomes for adolescents and youth, including reductions in health-risk behaviors.

What is NIH looking for beyond whether a program works?

The central aim is not only to document effectiveness, but to improve understanding of the specific program features and underlying mechanisms that drive positive change. Applicants are expected to articulate how and why PYD strategies influence outcomes and to link program components to measurable improvements in health and development.

What kinds of projects are invited under this announcement?

The announcement invites R01 applications proposing rigorous development, implementation, and evaluation of new or enhanced PYD programs, as well as careful evaluation of programs that have already demonstrated success.

Does this opportunity support evaluation of existing programs with prior evidence of success?

Yes. It explicitly encourages careful evaluation of programs that have already demonstrated success, with an emphasis on understanding program components and pathways that produce positive outcomes.

Are adaptation, translation, and dissemination studies encouraged?

Yes. The opportunity encourages research on evidence-based, gender-inclusive programs that are adapted or translated for new settings or populations, and/or disseminated more broadly.

What does the emphasis on adaptation and dissemination imply?

It signals interest in real-world impact, including studies that examine what it takes to maintain effectiveness when a proven program is modified for cultural relevance, delivered in a different community context, or scaled beyond its original environment.

What is the funding mechanism used for this opportunity?

The funding mechanism is the NIH Research Project Grant (R01), which is NIH's standard mechanism for supporting substantial, multi-year research projects.

Is there a related funding opportunity with the same scientific scope?

Yes. This R01 announcement runs in parallel with a separate funding opportunity of the same scientific scope that uses the R03 mechanism (PA-08-242), which typically supports smaller, more limited projects.

What level of scope and rigor is expected for the R01 version?

The expectation is that proposed studies will have scope, design, and an analytic plan appropriate for a full-scale research project, including strong evaluation methods and a clear articulation of the pathways through which PYD programs are expected to influence outcomes.

Is the number of awards or total funding amount guaranteed?

No. Funding availability and the number of awards are not fixed in advance. Awards are contingent on NIH having funds available and receiving enough high-quality, competitive applications.

How will funding decisions be determined?

Funding decisions depend on the overall merit of submitted applications and the budget environment at the time of review and award, as described in the announcement.

What type of grant is this categorized as?

This opportunity is categorized as a discretionary grant.

What CFDA numbers are associated with this opportunity?

The announcement lists multiple CFDA numbers reflecting the public health and human development domains covered, including: 93.273 (alcohol research), 93.279 (drug abuse and addiction research), 93.361 (nursing research), 93.393 (cancer cause and prevention research), and 93.865 (child health and human development extramural research).

What types of research topics and outcomes can fit under this announcement?

The scope suggests supported research may address multiple, intersecting outcomes and risk areas affecting adolescents, such as substance use and sexual health, as well as broader developmental health and prevention-related endpoints, as long as the work is grounded in PYD frameworks and produces evidence relevant to reducing risk behaviors and improving well-being.

Who is eligible to apply?

Eligibility is broad and includes many U.S. and non-U.S. entities. Eligible applicants include for-profit organizations (including small businesses), nonprofit organizations (including those with and without 501(c)(3) status), institutions of higher education (public and private), and multiple levels of government (state, county, city/township, special district), as well as independent school districts and public/Indian housing authorities.

Are mission-focused and underserved-serving institutions explicitly included?

Yes. The announcement explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments and tribal organizations, U.S. territories or possessions, regional organizations, and foreign (non-U.S.) organizations.

Are foreign (non-U.S.) organizations allowed to apply?

Yes. Foreign (non-U.S.) organizations are explicitly listed as eligible applicants in the announcement.

Is cost-sharing or matching required?

No. The announcement states there is no cost-sharing or matching requirement.

What are the key dates for this funding opportunity?

The posted date is August 15, 2008. The original and current closing date is September 7, 2011. The archive date is October 8, 2011.

Is this funding opportunity still open?

No. Because the closing date was September 7, 2011 and the archive date is October 8, 2011, the opportunity is no longer open for new submissions under this specific announcement (PA-08-241).

Where was the full announcement made available?

The full announcement was made available through the NIH grants guide (via the link referenced in the opportunity description).

Who can be contacted for technical access or linking issues?

The NIH Office of Extramural Research (OER) contact points are provided for technical access or linking issues, as noted in the opportunity information.

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Applicants also applied for:

Applicants who have applied for this opportunity (PA 08 241) also looked into and applied for these:

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Research on Teen Dating Violence (R21) Apply for PA 09 170

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Womens Mental Health in Pregnancy and the Postpartum Period (R01) Apply for PA 09 174

Funding Number: PA 09 174
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Womens Mental Health in Pregnancy and the Postpartum Period (R21) Apply for PA 09 175

Funding Number: PA 09 175
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Building Interdisciplinary Research Careers in Womens Health (K12) Apply for RFA OD 09 006

Funding Number: RFA OD 09 006
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Funding Number: RFA HD 09 006
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