Opportunity Information: Apply for PAR 14 340
Apply for PAR 14 340
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Request to Access Parkinsons Disease Related Biospecimens (X01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
- This funding opportunity was created on Sep 11, 2014 and posted on Sep 11, 2014.
- Applicants must submit their applications by Nov 12, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts For profit organizations other than small businesses County governments Small businesses State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity PAR-14-340, titled "Request to Access Parkinsons Disease Related Biospecimens (X01)," is an NIH-run access mechanism that lets researchers request Parkinsons disease (PD) biospecimens and the associated clinical data needed for biomarker discovery, optimization, and replication studies. Rather than functioning like a typical research grant that provides money to run experiments, the X01 mechanism is generally used to provide access to existing, high-value resources. In this case, the central purpose is to make well-characterized, already-collected PD samples available to qualified investigators so they can test hypotheses and evaluate biomarkers without needing to build a new cohort from scratch.
This opportunity is built around several major biospecimen and data resources that are hard to replicate independently. It draws from the NINDS Parkinsons Disease Biomarkers Program (PDBP), Parkinsons disease cohorts and biosample collections supported by The Michael J. Fox Foundation (MJFF), the NINDS-sponsored National Brain and Tissue Resource for Parkinsons Disease and Related Disorders housed at the Banner Sun Health Research Institute, and the Harvard Biomarker Study Biospecimen Repository. Collectively, these repositories provide access to unique sample types and linked clinical information that can be used to discover new biomarkers, refine promising candidates, and attempt replication across independent collections, which is often the deciding step in determining whether a biomarker is truly robust.
A key detail in the announcement is that investigators are applying specifically for access to "non-renewable" biosamples. That term signals that the samples are finite and cannot simply be recollected once they are used up, as can happen with scarce blood fractions, cerebrospinal fluid, or postmortem brain tissue from deeply phenotyped participants. Because of that, requests are typically expected to be well-justified, efficient in sample use, and aligned with the scientific value and feasibility of the proposed analyses. The intent is to allocate limited materials to projects that can make strong, credible contributions to the PD biomarker pipeline, including validation work that strengthens confidence in findings across different cohorts.
The program sits within NIHs neurological disorders portfolio under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and is administered by the National Institutes of Health, with NINDS as the scientific home. It is categorized as a discretionary grant opportunity, but the listed estimated total funding and award ceiling are both shown as $0, which is consistent with access-oriented mechanisms where the primary "award" is the ability to obtain samples and data rather than direct financial support. Cost sharing or matching is not required.
Eligibility is broad and includes many kinds of domestic U.S. organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, small businesses, other for-profit organizations (excluding non-small businesses in the "other than small businesses" category as listed), and various government entities including state, county, city/township, special district, and independent school districts. The announcement also allows participation by tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a wide range of mission-driven institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and other minority-serving institutions including Alaska Native and Native Hawaiian Serving Institutions and AANAPISI institutions. Importantly, non-U.S. entities are also eligible: foreign organizations and foreign institutions may apply, non-domestic components of U.S. organizations may apply, and foreign components are permitted as defined in the NIH Grants Policy Statement.
In terms of timing, the opportunity was posted on September 11, 2014, and it carried an original and current closing date of November 12, 2017, with an archive date of December 13, 2017. That means it is no longer active for new submissions, but it remains a useful reference point for how NIH and partners structured centralized access to PD biospecimens and linked clinical data. The full archived announcement is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-14-340.html, and the general contact listed for technical difficulties with accessing or linking to the announcement is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PAR-14-340 is best understood as a pathway for researchers to obtain scarce, high-quality Parkinsons disease biospecimens from established repositories, paired with clinical datasets, so they can perform rigorous biomarker work, especially studies that need independent sample sets for replication and confirmation.
FAQs: PAR-14-340 - Request to Access Parkinsons Disease Related Biospecimens (X01)
What is PAR-14-340?
PAR-14-340 is an NIH funding opportunity titled "Request to Access Parkinsons Disease Related Biospecimens (X01)." It is an access mechanism that allows qualified investigators to request Parkinsons disease (PD) biospecimens and associated clinical data for biomarker discovery, optimization, and replication studies.
Is this a traditional research grant that provides funding to run experiments?
No. The X01 mechanism described here is primarily used to provide access to existing high-value resources (biospecimens and linked data), not to provide money for conducting experiments. Consistent with that purpose, the opportunity lists an estimated total funding amount of $0 and an award ceiling of $0.
What is the main purpose of this opportunity?
The central purpose is to make well-characterized, already-collected Parkinsons disease biosamples available to qualified researchers so they can test hypotheses and evaluate biomarkers without having to build a new cohort from scratch.
What kinds of studies is this opportunity intended to support?
This opportunity is intended to support biomarker discovery, biomarker optimization, and biomarker replication studies in Parkinsons disease using existing biospecimens and associated clinical data.
What resources or repositories does PAR-14-340 draw from?
The opportunity is built around multiple major biospecimen and data resources, including the NINDS Parkinsons Disease Biomarkers Program (PDBP), Parkinsons disease cohorts and biosample collections supported by The Michael J. Fox Foundation (MJFF), the NINDS-sponsored National Brain and Tissue Resource for Parkinsons Disease and Related Disorders at Banner Sun Health Research Institute, and the Harvard Biomarker Study Biospecimen Repository.
Why are these resources important for Parkinsons disease biomarker research?
Collectively, these repositories provide access to unique, hard-to-recreate sample types and linked clinical information. This makes it possible to discover new biomarkers, refine promising candidates, and attempt replication across independent collections, which is often critical for confirming whether a biomarker is robust.
What does it mean that investigators are applying for access to "non-renewable" biosamples?
"Non-renewable" indicates that the biosamples are finite and cannot simply be recollected once used. This can apply to scarce blood fractions, cerebrospinal fluid, or postmortem brain tissue from deeply phenotyped participants.
How does the "non-renewable" nature of samples affect requests?
Because the materials are limited, requests are generally expected to be well-justified, efficient in sample use, and aligned with strong scientific value and feasibility. The intent is to allocate scarce samples to projects likely to make credible contributions to the PD biomarker pipeline, including validation and replication work.
Which NIH area or program is associated with this opportunity?
This opportunity sits within NIHs neurological disorders portfolio and is administered by the National Institutes of Health, with the National Institute of Neurological Disorders and Stroke (NINDS) as the scientific home.
What is the CFDA number associated with PAR-14-340?
The opportunity is listed under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
Who is eligible to apply?
Eligibility is broad. It includes many types of domestic U.S. organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), small businesses, other for-profit organizations (with an exclusion noted for non-small businesses in the "other than small businesses" category as listed), and various government entities (state, county, city/township, special district, and independent school districts). It also includes tribal governments and tribal organizations, and public housing authorities/Indian housing authorities.
Are minority-serving institutions included in the eligible organization types?
Yes. The announcement allows participation by a range of mission-driven institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and other minority-serving institutions including Alaska Native and Native Hawaiian Serving Institutions and AANAPISI institutions.
Are foreign organizations eligible to apply?
Yes. Non-U.S. entities are eligible. Foreign organizations and foreign institutions may apply, non-domestic components of U.S. organizations may apply, and foreign components are permitted as defined in the NIH Grants Policy Statement.
When was PAR-14-340 posted and when did it close?
The opportunity was posted on September 11, 2014. It carried an original and current closing date of November 12, 2017, and an archive date of December 13, 2017.
Is PAR-14-340 still active?
No. Based on the closing and archive dates provided (closing date November 12, 2017; archive date December 13, 2017), it is no longer active for new submissions.
Where can the full archived announcement be found?
The full archived announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-340.html
Who should be contacted for technical difficulties accessing or linking to the announcement?
The general contact listed for technical difficulties with accessing or linking to the announcement is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall takeaway for researchers considering this mechanism?
PAR-14-340 is best understood as a pathway for researchers to obtain scarce, high-quality Parkinsons disease biospecimens from established repositories, paired with clinical datasets, to support rigorous biomarker work, especially studies that require independent sample sets for replication and confirmation.
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