Opportunity Information: Apply for PA 13 120

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Alcohol and HIV/AIDS (R03)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
  • This funding opportunity was created on Mar 21, 2013 and posted on Mar 21, 2013.
  • Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities State governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal governments (Federally recognized) County governments Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The National Institutes of Health (NIH) offered this discretionary grant opportunity, titled Research on Alcohol and HIV/AIDS (R03), under Funding Opportunity Number PA-13-120 and CFDA 93.273 (Alcohol Research Programs). It used the R03 mechanism, which is designed to support small, focused research projects. The announcement was posted and created on March 21, 2013, with an original and final closing date of May 7, 2016, and it was archived on June 7, 2016. There was no cost sharing or matching requirement, meaning applicants were not expected to contribute non-federal funds as a condition of receiving the award.

The purpose of the FOA was to broaden and strengthen the research base at the intersection of alcohol misuse and HIV/AIDS. NIH explicitly aimed to draw in multiple types of investigators: alcohol researchers who had not previously worked in HIV/AIDS but understood how problem drinking can shape HIV risk and outcomes; HIV/AIDS researchers who had not previously focused on alcohol but recognized that alcohol-focused interventions may be essential for improving HIV-related clinical outcomes; and researchers already working on co-occurring HIV/AIDS and alcohol or other substance use. In practical terms, the FOA tried to create a bridge between two research communities that often operate in parallel, encouraging cross-training, new collaborations, and pilot studies that could generate preliminary data for larger future projects.

The announcement laid out three main research objectives. First, it sought projects that clarify how important alcohol misuse is in the acquisition and transmission of HIV. This includes work that helps quantify and explain how drinking patterns contribute to behaviors and contexts that increase HIV risk, with the goal of identifying which alcohol-related and HIV-related interventions are most appropriate to deploy as public health measures. The underlying emphasis is on prevention at the population level: understanding whether reducing alcohol misuse meaningfully reduces new HIV infections and, if so, how best to design and target combined alcohol and HIV prevention strategies.

Second, the FOA encouraged studies that examine how ongoing alcohol exposure affects HIV disease progression and how to prevent or mitigate those effects. This focus goes beyond initial infection risk and looks at what happens after someone is living with HIV, including how alcohol use may worsen health outcomes or interfere with effective disease management. While the text does not list specific subtopics, the intent is clearly to support research that improves understanding of mechanisms and pathways by which alcohol influences HIV progression and to inform strategies that reduce harm for people who continue to drink or struggle with alcohol misuse.

Third, NIH called for operational research frameworks that can address the occurrence and persistence of infections in high-risk populations and translate findings into interventions that are both effective and culturally appropriate. The FOA points to examples of populations at elevated risk, such as minority women and young gay men, signaling an interest in research that is grounded in real-world settings and attentive to social, cultural, and structural factors that shape risk and access to prevention and treatment. This objective is not just about describing disparities; it is about building workable models for intervention delivery, implementation, and translation so that research results can be turned into practical prevention and treatment approaches for the groups most affected.

Eligibility was broad and included many organization types across the public, private, nonprofit, and academic sectors. Eligible applicants included nonprofits with and without 501(c)(3) status, public and private institutions of higher education, small businesses, for-profit organizations (other than small businesses), independent school districts, state and local governments (including city/township and county governments), special district governments, public housing authorities/Indian housing authorities, and tribal entities (including federally recognized tribal governments and other tribal organizations). The FOA also explicitly included a range of mission-focused and equity-relevant institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Importantly, it allowed foreign participation: non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations could participate, and foreign components as defined by NIH policy were permitted. This structure reflects NIH interest in supporting research that may need to be conducted in diverse geographic and epidemic contexts, including international settings where HIV burden and alcohol-related risk patterns can differ.

Overall, this FOA was a targeted call for small, tightly scoped studies that generate actionable knowledge about how alcohol misuse and HIV intersect in prevention, transmission, disease progression, and implementation of interventions. By emphasizing both public health impact and culturally appropriate translation for high-risk populations, NIH framed the opportunity as not only a basic or clinical research question, but also a practical and implementation-oriented pathway to improving HIV prevention and care outcomes where alcohol plays a meaningful role.

Frequently Asked Questions (FAQs): NIH Research on Alcohol and HIV/AIDS (R03) - PA-13-120

What is this grant opportunity?

This is a discretionary funding opportunity from the National Institutes of Health (NIH) titled Research on Alcohol and HIV/AIDS (R03). It was offered under Funding Opportunity Number (FON) PA-13-120 and listed under CFDA 93.273 (Alcohol Research Programs).

What funding mechanism does this opportunity use?

The opportunity uses the R03 mechanism, which is designed to support small, focused research projects.

What was the overall purpose of the FOA?

The purpose was to broaden and strengthen the research base at the intersection of alcohol misuse and HIV/AIDS, including prevention, transmission, disease progression, and translation of findings into workable interventions.

Who was NIH trying to attract to apply?

NIH explicitly aimed to bring in multiple investigator communities, including:

  • Alcohol researchers who had not previously worked in HIV/AIDS but understood how problem drinking can shape HIV risk and outcomes
  • HIV/AIDS researchers who had not previously focused on alcohol but recognized alcohol-focused interventions may be essential for improving HIV-related clinical outcomes
  • Researchers already working on co-occurring HIV/AIDS and alcohol or other substance use

What kinds of projects was NIH hoping to encourage?

The FOA was designed to encourage cross-training, new collaborations, and pilot studies that could generate preliminary data to support larger future research projects.

What are the main research objectives described in the announcement?

The announcement laid out three main objectives:

  1. Clarify the role of alcohol misuse in HIV acquisition and transmission, including quantifying and explaining how drinking patterns contribute to risk behaviors and contexts, and informing which interventions should be used as public health measures.
  2. Examine how ongoing alcohol exposure affects HIV disease progression and identify ways to prevent or mitigate negative effects for people living with HIV.
  3. Develop operational research frameworks that address infection occurrence and persistence in high-risk populations and translate findings into interventions that are effective and culturally appropriate.

What does the FOA mean by linking alcohol misuse to HIV acquisition and transmission?

It refers to research that helps determine how important alcohol misuse is in driving new HIV infections, including understanding drinking patterns that increase risk and using that knowledge to design and target combined alcohol and HIV prevention strategies that work at a population level.

What does the FOA focus on for people already living with HIV?

The second objective targets research on how alcohol exposure may affect HIV disease progression and on approaches to prevent or reduce harm associated with alcohol misuse in the context of HIV disease management.

What does the FOA mean by "operational research frameworks" and "translation"?

This refers to research that is grounded in real-world conditions and supports moving findings into practical intervention delivery and implementation, especially interventions that are effective and culturally appropriate for high-risk populations.

Which high-risk populations are mentioned as examples?

The FOA gives examples of high-risk groups such as minority women and young gay men, signaling interest in work attentive to social, cultural, and structural factors affecting risk, prevention, and care.

Is this opportunity focused only on basic science, or also on applied and implementation research?

Based on the stated objectives and emphasis on translation and culturally appropriate interventions, the opportunity was framed to support not only research questions about mechanisms and outcomes, but also practical, implementation-oriented pathways to improve HIV prevention and care where alcohol plays a meaningful role.

Who was eligible to apply?

Eligibility was broad and included many organization types across public, private, nonprofit, and academic sectors. Eligible applicants included:

  • Nonprofits with or without 501(c)(3) status
  • Public and private institutions of higher education
  • Small businesses
  • For-profit organizations (other than small businesses)
  • Independent school districts
  • State governments
  • Local governments (including city/township and county governments)
  • Special district governments
  • Public housing authorities/Indian housing authorities
  • Tribal entities (federally recognized tribal governments and other tribal organizations)
  • Faith-based or community-based organizations
  • Eligible federal agencies

Were minority-serving institutions and other mission-focused institutions explicitly included?

Yes. The FOA explicitly included organizations such as HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian-serving institutions, and AANAPISIs.

Could foreign organizations apply?

Yes. The FOA allowed foreign participation, including:

  • Non-U.S. entities (foreign organizations and foreign institutions) applying directly
  • Non-U.S. components of U.S. organizations participating
  • Foreign components (as defined by NIH policy) being included

Was cost sharing or matching required?

No. There was no cost sharing or matching requirement, meaning applicants were not expected to contribute non-federal funds as a condition of receiving the award.

When was the FOA posted and created?

The announcement was posted and created on March 21, 2013.

What were the closing dates for the opportunity?

The FOA listed an original and final closing date of May 7, 2016.

Is this FOA still active?

No. It was archived on June 7, 2016, and the final closing date was May 7, 2016.

Why did NIH emphasize bridging alcohol research and HIV/AIDS research?

NIH described two research communities that often operate in parallel. This FOA aimed to create a bridge by encouraging collaboration and pilot work to generate actionable knowledge about how alcohol misuse affects HIV prevention, transmission, and outcomes.

What public health angle did NIH highlight in this FOA?

NIH emphasized prevention at the population level, including determining whether reducing alcohol misuse can meaningfully reduce new HIV infections and how to design and target combined alcohol and HIV interventions as public health measures.

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