Opportunity Information: Apply for PA 13 121

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Alcohol and HIV/AIDS (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
  • This funding opportunity was created on Mar 21, 2013 and posted on Mar 21, 2013.
  • Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Special district governments State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Apply for PA 13 121

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Opportunity Summary:

The National Institutes of Health (NIH) funding opportunity "Research on Alcohol and HIV/AIDS (R01)" (Funding Opportunity Number PA-13-121) is a discretionary grant program designed to support research at the intersection of alcohol misuse and HIV/AIDS. It is structured as an R01 mechanism, meaning it is intended for substantial, hypothesis-driven research projects that can advance scientific understanding and produce findings with practical relevance for prevention and treatment. The announcement deliberately targets a wide range of investigators, including alcohol researchers who have not previously worked in HIV/AIDS, HIV/AIDS researchers who have not previously focused on alcohol, and teams already experienced in studying co-occurring HIV and substance use. The overall aim is to grow and strengthen the evidence base on how alcohol use influences HIV risk, transmission, disease progression, and the effectiveness of interventions, especially in populations facing elevated vulnerability.

The FOA emphasizes three main research objectives. First, it seeks studies that clarify how important alcohol reduction is for preventing HIV acquisition and transmission, with the goal of identifying where alcohol-focused strategies can function as meaningful public health measures alongside established HIV prevention approaches. This includes research that helps determine when alcohol misuse is a key driver of risk behaviors or biological vulnerability, and how integrating alcohol interventions into HIV prevention programs could improve outcomes at the individual and community level. Second, the program calls for research to better understand and prevent HIV disease progression when alcohol exposure continues, recognizing that ongoing drinking may worsen clinical trajectories, interfere with care engagement, or complicate treatment response. Third, it encourages development of operational research frameworks that address why infections occur and persist in high-risk populations, and that translate research findings into effective, culturally appropriate prevention and treatment interventions. The announcement gives examples of priority populations such as minority women and young gay men, reflecting an expectation that applicants consider real-world contexts, structural drivers, and culturally grounded approaches rather than one-size-fits-all solutions.

In practical terms, this FOA is positioned to fund work ranging from epidemiology and behavioral science to clinical and implementation research, as long as the proposed project directly informs the alcohol-HIV connection and produces insights that can be applied to public health practice or clinical care. The language about "operational research frameworks" signals interest in studies that do more than describe a problem; NIH is also looking for research that can be translated into interventions, service delivery models, or prevention strategies that are feasible in the settings where high-risk groups actually receive care or prevention services. Because the scope is broad, applicants are explicitly urged to review the full announcement carefully for additional research opportunities and expectations.

Eligibility is intentionally broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city, township, and special district governments; public housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and tribal governments and tribal organizations (including entities beyond federally recognized tribal governments). The FOA also notes eligibility for a wide set of institutional categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, U.S. territories or possessions, and regional organizations. Importantly, non-domestic (non-U.S.) entities and foreign institutions are eligible to apply, non-domestic components of U.S. organizations may apply, and foreign components (as defined by NIH policy) are allowed, making the opportunity relevant for international HIV research contexts where alcohol-related risk and treatment challenges may be prominent.

The program falls under the NIH health funding activity category and is associated with CFDA 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement, which generally lowers barriers for applicants who may not have institutional funds to contribute. The FOA was posted and created on March 21, 2013, with an original and current closing date of May 7, 2016, and an archive date of June 7, 2016, indicating that this specific announcement is no longer open but remains a useful reference point for the NIH research priorities and the types of projects that were sought during the active period. For full details, NIH provided an official guide link (http://grants.nih.gov/grants/guide/pa-files/PA-13-121.html). For access or technical issues related to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs) - NIH Research on Alcohol and HIV/AIDS (R01) (PA-13-121)

What is the NIH grant opportunity "Research on Alcohol and HIV/AIDS (R01)" (PA-13-121)?

This is a National Institutes of Health (NIH) discretionary grant funding opportunity focused on research at the intersection of alcohol misuse and HIV/AIDS. It uses the R01 mechanism and is intended to support substantial, hypothesis-driven research that advances scientific understanding and produces findings with practical relevance for HIV prevention and treatment.

What is the funding opportunity number?

The funding opportunity number is PA-13-121.

What does it mean that this is an R01 mechanism?

An R01 is intended for substantial research projects, typically hypothesis-driven, that can generate impactful scientific findings. In this announcement, the R01 structure signals that NIH was seeking rigorous studies capable of advancing knowledge and informing real-world prevention or clinical care related to alcohol and HIV.

What is the main purpose of this FOA?

The overall aim is to grow and strengthen the evidence base on how alcohol use influences HIV risk, transmission, disease progression, and the effectiveness of interventions, particularly in populations facing elevated vulnerability.

What types of investigators is this FOA meant to attract?

The announcement deliberately targets a wide range of investigators, including alcohol researchers new to HIV/AIDS, HIV/AIDS researchers new to alcohol-focused work, and teams already experienced in studying co-occurring HIV and substance use.

What are the primary research objectives highlighted in the announcement?

The FOA emphasizes three main objectives: (1) clarify how important alcohol reduction is for preventing HIV acquisition and transmission, (2) better understand and prevent HIV disease progression when alcohol exposure continues, and (3) develop operational research frameworks that explain why infections occur and persist in high-risk populations and translate findings into effective, culturally appropriate prevention and treatment interventions.

What kinds of questions fit under the HIV prevention objective?

The FOA calls for studies that help determine when alcohol misuse is a key driver of HIV risk behaviors or biological vulnerability, and whether integrating alcohol interventions into HIV prevention programs improves outcomes at individual and community levels.

What does the FOA say about alcohol use and HIV disease progression?

It recognizes that ongoing alcohol exposure may worsen clinical trajectories, interfere with care engagement, or complicate treatment response, and it encourages research aimed at better understanding and preventing HIV disease progression in the context of continued alcohol use.

What does NIH mean by "operational research frameworks" in this FOA?

Based on the language in the announcement, this signals interest in research that goes beyond describing the problem and instead supports translation of findings into interventions, service delivery models, or prevention strategies that are feasible in real-world settings serving high-risk groups.

Does the FOA prioritize specific populations?

Yes. It provides examples of priority populations such as minority women and young gay men. The FOA also reflects an expectation that applicants consider real-world contexts, structural drivers, and culturally grounded approaches rather than one-size-fits-all solutions.

What research areas or disciplines are within scope?

The scope is broad and positioned to fund work ranging from epidemiology and behavioral science to clinical and implementation research, as long as the proposed project directly informs the alcohol-HIV connection and produces insights that can be applied to public health practice or clinical care.

Is the FOA focused only on describing associations, or does it support intervention-oriented research?

The FOA explicitly signals interest in translation and practical relevance, including research that can inform interventions, service delivery models, or prevention strategies that work in settings where high-risk groups receive care or prevention services.

Who is eligible to apply?

Eligibility is broad and includes many U.S. and non-U.S. organization types. Eligible applicants include state, county, city, township, and special district governments; public housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and tribal governments and tribal organizations (including entities beyond federally recognized tribal governments).

Are higher education institutions eligible?

Yes. Both public/state-controlled and private institutions of higher education are listed as eligible.

Are nonprofit organizations required to have 501(c)(3) status to apply?

No. The FOA states that nonprofit organizations with or without 501(c)(3) status are eligible.

Are for-profit entities eligible?

Yes. The FOA includes for-profit organizations (other than small businesses) as well as small businesses.

Are tribal governments and tribal organizations eligible?

Yes. The FOA includes tribal governments and tribal organizations, including eligible entities beyond federally recognized tribal governments.

Are non-U.S. (foreign) organizations allowed to apply?

Yes. Non-domestic (non-U.S.) entities and foreign institutions are eligible to apply. The FOA also allows non-domestic components of U.S. organizations and foreign components (as defined by NIH policy).

Does the FOA mention specific types of institutions and community organizations as eligible?

Yes. It notes eligibility for categories such as HBCUs; Hispanic-serving Institutions; Alaska Native and Native Hawaiian Serving Institutions; Asian American and Native American Pacific Islander Serving Institutions; Tribally Controlled Colleges and Universities; faith-based or community-based organizations; U.S. territories or possessions; and regional organizations.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

What is the CFDA number associated with this funding opportunity?

The FOA is associated with CFDA 93.273 (Alcohol Research Programs).

When was the FOA posted, and what were the closing and archive dates?

The FOA was posted and created on March 21, 2013. The original and current closing date was May 7, 2016, and the archive date was June 7, 2016.

Is this specific funding opportunity still open?

No. Based on the provided closing and archive dates, this specific announcement is no longer open. It remains useful as a reference for NIH research priorities and the types of projects sought during its active period.

Where can applicants find the official NIH announcement page?

The official guide link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-13-121.html

Who should be contacted for access or technical issues related to the announcement?

The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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