Opportunity Information: Apply for PA 13 122
Apply for PA 13 122
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Alcohol and HIV/AIDS (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Mar 21, 2013 and posted on Mar 21, 2013.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: City or township governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Research on Alcohol and HIV/AIDS (R21)" (Funding Opportunity Number PA-13-122) was a discretionary, short-term exploratory/developmental research grant designed to spark new and innovative studies at the intersection of alcohol misuse and HIV/AIDS. It was deliberately written to attract a wide range of investigators, including alcohol researchers who had not previously worked in HIV/AIDS but recognize how problem drinking can increase HIV risk and worsen outcomes, HIV/AIDS researchers who had not focused on alcohol but see the need for stronger alcohol-focused interventions to improve clinical results for people living with HIV, and teams already working on co-occurring HIV and alcohol or other substance use. The emphasis on the R21 mechanism signals that the program was especially interested in early-stage, proof-of-concept, and developmental projects that can open new directions, generate preliminary data, or refine approaches that could later grow into larger, confirmatory studies.
The core purpose of the FOA was to expand the evidence base on how alcohol use influences HIV acquisition, transmission, disease progression, and persistence of infection in vulnerable populations, while also moving toward practical prevention and treatment solutions. The announcement highlighted three main research objectives. First, it aimed to clarify how important reducing alcohol misuse is for preventing HIV acquisition and transmission, and how alcohol-focused and HIV-focused interventions can be paired or applied as public health measures. This includes work that helps disentangle the role alcohol plays in behaviors and circumstances that raise HIV risk, and research that tests how alcohol reduction strategies might strengthen existing HIV prevention efforts.
Second, the FOA sought research that improves understanding of HIV disease progression in the context of ongoing alcohol exposure, with an eye toward preventing or reducing harm. This objective reflects concerns that alcohol misuse can complicate HIV management through multiple pathways, such as poorer adherence to antiretroviral therapy, increased comorbidities, and biological effects that may influence immune function. Projects under this objective could include studies that investigate mechanisms, identify modifiable risk factors, or develop and pilot interventions intended to mitigate alcohol-related worsening of HIV outcomes.
Third, the FOA encouraged the development of operational research frameworks that address why infections occur and persist in high-risk populations and how research findings can be translated into effective, culturally appropriate prevention and treatment interventions. The announcement explicitly referenced populations such as minority women and young gay men as examples of groups that may face elevated risk due to overlapping social, structural, and behavioral factors. The focus here was not only on understanding risk, but on building approaches that work in real-world settings, can be implemented feasibly, and are tailored to the cultural and contextual needs of the communities being served.
From an administrative standpoint, this opportunity was offered by the National Institutes of Health under CFDA 93.273 (Alcohol Research Programs). It did not require cost sharing or matching. The award ceiling listed was $200,000. The FOA was posted on March 21, 2013, and it had an original and final closing date of May 7, 2016, with an archive date of June 7, 2016, meaning it is no longer open for applications.
Eligibility was broad and included many types of domestic applicants such as state, county, city, and special district governments; public housing authorities; tribal governments and tribal organizations; public and private institutions of higher education; independent school districts; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations including small businesses. The FOA also allowed applications from non-U.S. entities and foreign institutions, and permitted foreign components of U.S. organizations as defined in NIH policy. In addition, it explicitly included a wide range of mission-relevant institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies.
Overall, PA-13-122 positioned alcohol misuse as a critical and sometimes under-addressed driver of HIV risk and outcomes, and it used the R21 mechanism to push the field toward new ideas, early testing of interventions, and practical frameworks that can be translated into culturally appropriate prevention and treatment strategies for populations carrying disproportionate HIV burden. For full details, NIH linked applicants to the complete announcement at http://grants.nih.gov/grants/guide/pa-files/PA-13-122.html, with technical access support routed through the NIH Office of Extramural Research webmaster.
FAQs: NIH "Research on Alcohol and HIV/AIDS (R21)" (PA-13-122)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Research on Alcohol and HIV/AIDS (R21)" and the Funding Opportunity Number (FON) is PA-13-122.
What type of grant mechanism is this opportunity using?
This announcement uses the NIH R21 mechanism, described as a short-term exploratory/developmental research grant. The focus is on early-stage, proof-of-concept, and developmental projects that can open new directions, generate preliminary data, or refine approaches that could later grow into larger studies.
Is this funding opportunity still open for applications?
No. The FOA listed an original and final closing date of May 7, 2016, with an archive date of June 7, 2016, meaning it is no longer open for applications.
When was the FOA posted, and when did it close?
The FOA was posted on March 21, 2013. The original and final closing date was May 7, 2016, and it was archived on June 7, 2016.
What is the overall purpose of PA-13-122?
The core purpose was to expand evidence on how alcohol use influences HIV acquisition, transmission, disease progression, and persistence of infection, especially in vulnerable populations, while also moving toward practical prevention and treatment solutions.
What kinds of investigators was this FOA designed to attract?
It was deliberately written to attract a wide range of investigators, including:
- Alcohol researchers who had not previously worked in HIV/AIDS but recognize that problem drinking can increase HIV risk and worsen outcomes
- HIV/AIDS researchers who had not focused on alcohol but see the need for alcohol-focused interventions to improve outcomes for people living with HIV
- Teams already working on co-occurring HIV and alcohol (or other substance use)
What research areas or topics did the FOA emphasize?
The FOA centered on research at the intersection of alcohol misuse and HIV/AIDS, including how alcohol affects HIV risk, transmission, disease progression, and the persistence of infection, along with studies that move toward prevention and treatment solutions.
What were the three main research objectives described in the announcement?
The announcement highlighted three objectives:
- Clarify how important reducing alcohol misuse is for preventing HIV acquisition and transmission, and how alcohol-focused and HIV-focused interventions can be paired or used as public health measures.
- Improve understanding of HIV disease progression in the context of ongoing alcohol exposure, with an emphasis on preventing or reducing harm.
- Develop operational research frameworks to explain why infections occur and persist in high-risk populations and how findings can be translated into effective, culturally appropriate prevention and treatment interventions.
What does the FOA say about alcohol reduction and HIV prevention?
It aimed to clarify how reducing alcohol misuse can help prevent HIV acquisition and transmission, including research that disentangles alcohol's role in behaviors and circumstances that raise HIV risk and research that tests whether alcohol reduction strategies can strengthen existing HIV prevention efforts.
How did the FOA describe the link between alcohol misuse and HIV disease progression?
The FOA reflected concerns that alcohol misuse can complicate HIV management through multiple pathways, including poorer adherence to antiretroviral therapy, increased comorbidities, and biological effects that may influence immune function. It encouraged studies investigating mechanisms, modifiable risk factors, or pilot interventions to mitigate alcohol-related worsening of HIV outcomes.
What are "operational research frameworks" in the context of this FOA?
Within this announcement, operational research frameworks refer to approaches that address why infections occur and persist in high-risk populations and how research findings can be translated into prevention and treatment interventions that are effective, feasible to implement in real-world settings, and culturally appropriate for the communities served.
Did the FOA reference specific high-risk or disproportionately affected populations?
Yes. It explicitly referenced minority women and young gay men as examples of groups that may face elevated risk due to overlapping social, structural, and behavioral factors.
Which NIH program area and CFDA number were associated with this opportunity?
This opportunity was offered under CFDA 93.273, listed as Alcohol Research Programs.
What was the maximum award amount (award ceiling) listed?
The FOA listed an award ceiling of $200,000.
Did this opportunity require cost sharing or matching funds?
No. The FOA stated that it did not require cost sharing or matching.
Who was eligible to apply (in general terms)?
Eligibility was broad and included many types of applicants, including governments, educational institutions, nonprofits, for-profits, and others. The FOA also allowed certain international participation (non-U.S. entities and foreign institutions, plus foreign components of U.S. organizations as defined in NIH policy).
What types of U.S. government entities were eligible?
The FOA included domestic applicants such as state, county, city, and special district governments, as well as public housing authorities.
Were tribal governments and tribal organizations eligible?
Yes. The FOA explicitly included tribal governments and tribal organizations among eligible applicants.
Were colleges, universities, and school districts eligible to apply?
Yes. Eligible applicants included public and private institutions of higher education and independent school districts.
Could nonprofit organizations apply, including those without 501(c)(3) status?
Yes. The FOA included nonprofit organizations with or without 501(c)(3) status.
Could for-profit organizations and small businesses apply?
Yes. The FOA included for-profit organizations, including small businesses.
Were non-U.S. entities or foreign institutions allowed to apply?
Yes. The FOA allowed applications from non-U.S. entities and foreign institutions and also permitted foreign components of U.S. organizations as defined in NIH policy.
Did the FOA name specific institution types it wanted to include?
Yes. It explicitly included mission-relevant institutions and organizations such as HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.
Were faith-based or community-based organizations eligible?
Yes. The FOA explicitly included faith-based and community-based organizations among eligible applicants.
Were federal agencies eligible to apply?
Yes. The FOA included eligible federal agencies.
What kinds of projects did the R21 emphasis suggest NIH wanted?
The R21 emphasis signaled interest in early-stage and developmental projects, such as proof-of-concept efforts that generate preliminary data, test new ideas, refine methods or interventions, and open up new lines of research that could later be expanded into larger confirmatory studies.
Where can the full FOA text be found?
NIH linked applicants to the complete announcement at: http://grants.nih.gov/grants/guide/pa-files/PA-13-122.html.
Where was technical access support directed for this announcement?
Technical access support was routed through the NIH Office of Extramural Research webmaster.
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