Opportunity Information: Apply for W81XWH 13 PRORP CTA

  • The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Orthopaedic Clinical Trial Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
  • This funding opportunity was created on Feb 21, 2013 and posted on Feb 21, 2013.
  • Applicants must submit their applications by Jul 18, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $11,250,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
Apply for W81XWH 13 PRORP CTA

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Opportunity Summary:

The DoD Peer Reviewed Orthopaedic Clinical Trial Award (PRORP Clinical Trial Award) is a Department of Defense funding opportunity run through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP). Its central purpose is to move quickly from promising ideas to real-world clinical testing by supporting the rapid implementation of clinical trials that could meaningfully improve outcomes for people dealing with combat-related orthopaedic injuries. In practical terms, this program is aimed at studies that are ready to be executed as clinical trials and that have clear potential to change clinical practice for service members and Veterans affected by serious musculoskeletal trauma.

The types of trials this award supports are broad, as long as they squarely address orthopaedic needs tied to combat injury. Proposed studies can evaluate new or improved products, pharmacologic agents such as drugs or biologics, medical devices, clinical guidance or care pathways, and emerging approaches or technologies that could improve recovery, function, pain outcomes, complications, or long-term quality of life after orthopaedic trauma. The emphasis is on impact: the trial should be positioned to answer an important clinical question and generate evidence that could influence care for military and Veteran populations.

A core requirement is that every application clearly justifies relevance to military and/or Veteran populations affected by combat-related orthopaedic injury. This is not optional background framing; it is a fundamental part of the scientific and programmatic case for funding. The opportunity also actively encourages collaboration with military researchers and clinicians, reflecting the program's focus on operationally relevant research and on making sure trial design and execution align with military health needs and realities. During programmatic review, studies that include active-duty military personnel or Veterans as some or all of the study population are expected to receive higher priority for funding, meaning applicants who can enroll these participants or otherwise build the trial around these populations may be more competitive.

Administratively, this opportunity was posted on February 21, 2013, with an original and final closing date of July 18, 2013, and an archive date of August 17, 2013. It was offered as either a cooperative agreement or a grant, in the category of science and technology and other research and development. The program anticipated making about three awards, with an estimated total funding amount of $11,250,000. There was no cost-sharing or matching requirement, which means applicants were not required to contribute non-federal funds as a condition of award. Eligibility was listed as unrestricted, indicating that a wide range of applicant organization types could apply, subject to any additional eligibility details that may have been included in the full announcement text.

The opportunity is associated with CFDA number 12.420 (Military Medical Research and Development) and is identified by Funding Opportunity Number W81XWH-13-PRORP-CTA. For assistance accessing the full announcement, the contact listed was the CDMRP Help Desk at 301-682-5507 or help@cdmrp.org.

Frequently Asked Questions (FAQs)

What is the PRORP Clinical Trial Award?

The DoD Peer Reviewed Orthopaedic Clinical Trial Award (PRORP Clinical Trial Award) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP). It supports the rapid implementation of clinical trials intended to improve outcomes for people with combat-related orthopaedic injuries.

What is the main purpose of this funding opportunity?

The central purpose is to move quickly from promising ideas to real-world clinical testing by funding clinical trials that could meaningfully improve recovery and long-term outcomes for service members and Veterans affected by serious musculoskeletal trauma from combat-related orthopaedic injury.

What kinds of studies does this award support?

This opportunity supports studies that are ready to be executed as clinical trials and that have clear potential to influence clinical practice for military and Veteran populations impacted by combat-related orthopaedic injuries.

What types of clinical trials are within scope?

The award supports a broad range of clinical trials as long as they directly address orthopaedic needs tied to combat injury. Examples of trial targets mentioned include new or improved products, pharmacologic agents such as drugs or biologics, medical devices, clinical guidance or care pathways, and emerging approaches or technologies.

What outcomes or impacts is the program trying to improve?

Proposed trials should have the potential to improve outcomes such as recovery, function, pain outcomes, complications, or long-term quality of life after orthopaedic trauma, with an emphasis on generating evidence that could influence care for military and Veteran populations.

How important is military or Veteran relevance in the application?

Military and/or Veteran relevance is a core requirement. Every application must clearly justify relevance to military and/or Veteran populations affected by combat-related orthopaedic injury. This is described as fundamental to the scientific and programmatic case for funding, not optional background context.

Are collaborations with military researchers or clinicians encouraged?

Yes. The opportunity actively encourages collaboration with military researchers and clinicians to help ensure trial design and execution align with military health needs and realities.

Does enrolling active-duty military personnel or Veterans affect funding priority?

Yes. During programmatic review, studies that include active-duty military personnel or Veterans as some or all of the study population are expected to receive higher priority for funding. Trials built around these populations may be more competitive.

What award mechanisms are available?

The funding opportunity was offered as either a cooperative agreement or a grant.

What was the estimated number of awards and total funding?

The program anticipated making about three awards, with an estimated total funding amount of $11,250,000.

Is cost sharing or matching required?

No. There was no cost-sharing or matching requirement, meaning applicants were not required to contribute non-federal funds as a condition of award.

Who was eligible to apply?

Eligibility was listed as unrestricted, indicating that a wide range of applicant organization types could apply (subject to any additional eligibility details that may have been included in the full announcement text).

What is the Funding Opportunity Number for this program?

The Funding Opportunity Number is W81XWH-13-PRORP-CTA.

What is the CFDA number associated with this opportunity?

The opportunity is associated with CFDA number 12.420, Military Medical Research and Development.

When was this opportunity posted and when did it close?

It was posted on February 21, 2013. The original and final closing date was July 18, 2013. The archive date was August 17, 2013.

What general category does this opportunity fall under?

It was categorized under science and technology and other research and development.

Who administered the program?

The opportunity was run through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Congressionally Directed Medical Research Programs (CDMRP) within the Department of Defense.

What should applicants emphasize in a competitive trial concept (based on the description)?

Based on the description, applications should emphasize readiness for rapid trial implementation, a trial design positioned to answer an important clinical question, clear potential to change clinical practice, and a strong, explicit justification of relevance to military and/or Veteran populations affected by combat-related orthopaedic injury. Including active-duty military personnel or Veterans in the study population is expected to improve funding priority during programmatic review.

Where can someone get help accessing the full announcement?

Assistance was available through the CDMRP Help Desk at 301-682-5507 or by email at help@cdmrp.org.

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