Opportunity Information: Apply for PA 07 085
Apply for PA 07 085
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Research On Autism And Autism Spectrum Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jan 16, 2009 and posted on Nov 22, 2006.
- Applicants must submit their applications by Sep 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments County governments State governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Independent school districts.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Research on Autism and Autism Spectrum Disorders (R01) funding opportunity (PA 07-085) is a National Institutes of Health (NIH) announcement that invites full-scale research project grant applications aimed at improving understanding of autism and related autism spectrum disorders. The central focus is on research that can clarify how these conditions are identified and diagnosed, how common they are and how they are distributed across populations (epidemiology), what causes or contributes to them (etiology), what genetic factors are involved, which treatments are effective, and what approaches to services and care delivery work best in real-world settings. The FOA explicitly includes work relevant to Autistic Disorder as well as diagnoses historically categorized under the spectrum such as Rett's Disorder, Childhood Disintegrative Disorder, Asperger's Disorder, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS), and atypical autism. It is broad by design and encourages basic science, clinical research, and applied or services research, meaning projects can range from mechanistic laboratory studies to clinical trials to implementation and systems-level studies that test how to deliver interventions and supports efficiently and equitably.
This opportunity uses the NIH R01 mechanism, which is the standard grant format for investigator-initiated research projects that are typically more mature and substantial in scope than exploratory awards. The announcement also notes that it runs in parallel with two companion opportunities that cover the same scientific space but use different mechanisms: the R03 small grant (PA 06-391) and the R21 exploratory/developmental grant (PA 06-392). In practical terms, that means investigators should choose the mechanism that matches the maturity, scale, and risk profile of their proposal, with the R01 generally fitting projects that already have a strong rationale and a well-developed research plan.
The scientific direction is tied to the Autism Research Matrix referenced by NIH, which is intended to organize and prioritize autism research topics across domains such as biology, risk factors, treatments and interventions, and services. While the FOA itself does not restrict applicants to narrow topic areas, the reference to the Matrix signals that proposals should connect to established research priorities and should be framed in a way that advances broader national research goals in autism.
Funding levels and the number of awards are not preset. Instead, NIH indicates that award size and project duration will vary depending on the proposed work, and that final totals will depend on the quality of applications received, the costs requested, the length of proposed projects, and the overall number of meritorious submissions. In other words, it is a competitive, peer-reviewed opportunity where the portfolio that gets funded is determined by application strength and programmatic considerations rather than a fixed allocation.
Eligibility is expansive and includes many types of domestic and international organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), state and local governments (including counties, cities/townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and Native American tribal governments as well as other tribal organizations. The FOA also clarifies that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations are also eligible. Cost sharing or matching is not required, which means applicants are not expected to provide non-federal matching funds as a condition of award.
Administratively, the opportunity is categorized as discretionary funding and uses the grant instrument type. It is associated with multiple CFDA numbers spanning environmental health, communication disorders, mental health research, nursing research, neuroscience/neurological disorders, and child health and human development, reflecting the cross-cutting nature of autism research across NIH institutes and mission areas. The opportunity was posted on November 22, 2006, and it used multiple receipt dates rather than a single deadline, with the current closing date listed as September 7, 2009 and an archive date of October 8, 2009. The full announcement was made available through the NIH grants guide at the provided link, and NIH’s Office of Extramural Research (OER) webmaster contact is included for technical access or linking problems.
Overall, PA 07-085 is structured to support comprehensive, hypothesis-driven autism research projects that can deepen scientific understanding and improve outcomes through better diagnosis, clearer knowledge of causes and risk, more effective interventions, and stronger service delivery models that meet the needs of individuals with autism and their families across settings and across the lifespan.
FAQs: Research on Autism and Autism Spectrum Disorders (R01) - PA 07-085
What is PA 07-085?
PA 07-085 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Research on Autism and Autism Spectrum Disorders (R01)." It invites applications for full-scale research project grants that aim to improve understanding of autism and autism spectrum disorders across areas such as diagnosis, epidemiology, causes, genetics, treatments, and service delivery.
What type of award mechanism does this opportunity use?
This FOA uses the NIH R01 mechanism, which is the standard NIH research project grant format typically used for more mature, substantial, hypothesis-driven projects with a well-developed research plan.
What kinds of research topics are within scope?
The FOA is broad and supports research intended to clarify how autism and related conditions are identified and diagnosed, how common they are and how they are distributed across populations (epidemiology), what causes or contributes to them (etiology), what genetic factors are involved, which treatments are effective, and what service and care delivery approaches work best in real-world settings.
Does this FOA support basic science, clinical research, and applied research?
Yes. The announcement encourages basic science, clinical research, and applied/services research. Projects may range from mechanistic laboratory studies to clinical trials to implementation and systems-level studies focused on delivering interventions and supports efficiently and equitably.
Which autism-related diagnoses are explicitly included?
The FOA explicitly includes work relevant to Autistic Disorder and also includes diagnoses historically categorized within the spectrum, such as Rett's Disorder, Childhood Disintegrative Disorder, Asperger's Disorder, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS), and atypical autism.
Is the FOA limited to a narrow set of topic areas?
No. It is broad by design. While it does not restrict applicants to narrow topic areas, it references the NIH Autism Research Matrix, signaling that proposals should connect to established research priorities and advance broader national research goals in autism.
What is the Autism Research Matrix and how does it relate to this FOA?
The Autism Research Matrix is referenced by NIH as a way to organize and prioritize autism research topics across domains such as biology, risk factors, treatments and interventions, and services. The FOA reference suggests applicants should frame their projects in ways that align with recognized research priorities, even though the FOA itself remains broad.
Are there companion FOAs for smaller or more exploratory projects?
Yes. The announcement notes two companion opportunities covering the same scientific space but using different mechanisms: the R03 small grant (PA 06-391) and the R21 exploratory/developmental grant (PA 06-392).
How should applicants choose between R01, R03, and R21 for autism research?
Investigators are encouraged to choose the mechanism that matches the maturity, scale, and risk profile of the proposal. The R01 is generally appropriate for projects with a strong rationale and a well-developed plan, while the R03 and R21 mechanisms are referenced as alternatives for smaller or more exploratory efforts.
Are the funding amounts and number of awards fixed?
No. NIH indicates that award size and project duration will vary depending on the proposed work. The total number of awards and overall funding levels depend on factors such as application quality, requested costs, proposed project length, and the number of meritorious applications received.
Is this a competitive, peer-reviewed opportunity?
Yes. The FOA is described as competitive and peer-reviewed, with funding outcomes determined by the strength and merit of applications and programmatic considerations rather than a fixed allocation.
Who is eligible to apply?
Eligibility is expansive. Eligible applicants include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); state and local governments (including counties, cities/townships, special district governments, and independent school districts); public housing authorities/Indian housing authorities; Native American tribal governments and other tribal organizations; and faith-based or community-based organizations. The FOA also clarifies that foreign institutions may apply and eligible federal agencies may apply.
Are international (foreign) institutions allowed to apply?
Yes. The FOA explicitly states that foreign institutions may apply.
Can for-profit organizations apply?
Yes. For-profit organizations are listed as eligible applicants, including small businesses and other for-profit entities.
Can nonprofits without 501(c)(3) status apply?
Yes. The eligibility list includes nonprofits with and without 501(c)(3) status.
Are state and local government entities eligible?
Yes. The FOA includes state and local governments, including counties, cities/townships, special district governments, and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments and other tribal organizations are included in the eligibility list.
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based or community-based organizations are also eligible.
Is cost sharing or matching required?
No. Cost sharing or matching is not required, meaning applicants are not expected to provide non-federal matching funds as a condition of award.
What is the funding instrument type and funding category?
The opportunity is categorized as discretionary funding and uses the grant instrument type.
Which CFDA program areas are associated with this FOA?
The FOA is associated with multiple CFDA numbers spanning areas including environmental health, communication disorders, mental health research, nursing research, neuroscience/neurological disorders, and child health and human development. This reflects the cross-cutting nature of autism research across NIH institutes and mission areas.
When was PA 07-085 posted, and what are the key dates listed?
The opportunity was posted on November 22, 2006. It used multiple receipt dates rather than a single deadline. The listed closing date is September 7, 2009, and the archive date is October 8, 2009.
Does this FOA have a single application deadline?
No. The information provided states that the FOA used multiple receipt dates rather than a single deadline.
Where was the full FOA announcement published?
The full announcement was made available through the NIH grants guide at the provided link in the original notice.
Who is listed as a technical contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact is included for technical access or linking problems.
What is the overall purpose of this R01 opportunity?
Overall, PA 07-085 is structured to support comprehensive autism research projects that deepen scientific understanding and improve outcomes through better diagnosis, clearer knowledge of causes and risk, more effective interventions, and stronger service delivery models that meet the needs of individuals with autism and their families across settings and across the lifespan.
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