Opportunity Information: Apply for RFA AA 13 003
Apply for RFA AA 13 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 3, 2013 and posted on Mar 27, 2013.
- Applicants must submit their applications by May 29, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Independent school districts Special district governments County governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments Small businesses Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R01) is a National Institutes of Health (NIH) discretionary grant opportunity focused on a persistent and costly gap in HIV care: people living with HIV who drink heavily or have alcohol use disorders often do not receive alcohol-focused services that are well integrated with HIV treatment. The announcement emphasizes that this population is underserved and faces elevated risks that directly affect HIV outcomes, including medication non-adherence, faster disease progression, higher likelihood of medication toxicities, organ damage or failure, poor viral suppression, increased chances of HIV transmission, and earlier mortality. The rationale for the initiative is the significant potential public health payoff: the notice cites estimates suggesting that better implementation of alcohol interventions for people with HIV could reduce new infections by nearly 20 percent and extend life by as much as 15 years in certain at-risk and patient populations.
The central purpose of the solicitation is to advance practical, decision-relevant evidence in two related areas: comparative effectiveness and implementation. In plain terms, NIH is looking for research that can help clinicians, health systems, and communities understand which alcohol-related interventions work best for different groups of people with HIV, and how to deliver those interventions consistently and effectively in real-world settings. The opportunity highlights that outcomes are influenced by more than the intervention itself. Applicants are encouraged to investigate patient-level and provider-level characteristics (such as factors that shape engagement, readiness, adherence, and care preferences), as well as organizational, financial, and structural conditions that either support or block the delivery of evidence-based care. The intended end product is actionable knowledge that improves clinical decision-making, strengthens treatment outcomes, and reduces potential harms linked to interventions among HIV patients with varying severities and patterns of alcohol use.
The announcement is explicitly split into two parts, and applicants may choose to address one part or both. The first part centers on comparative effectiveness research aimed at understanding what drives engagement in appropriate alcohol and HIV care and what helps people remain in treatment over time. This includes studying why some patients connect to services while others drop out, and how different approaches compare when measured by outcomes that matter in HIV care, such as retention, adherence to antiretroviral therapy, and viral suppression. The second part focuses on modeling and testing alternative implementation approaches. That means examining strategies for rolling out proven interventions in diverse settings, evaluating how different delivery models affect HIV transmission and disease progression, and identifying scalable methods that work under real constraints like staffing, reimbursement, workflow, and local infrastructure.
A core theme running through the opportunity is patient-centered care and improved health care delivery research. The solicitation frames the work as a way to help patients and providers make more informed decisions by generating evidence that is relevant to day-to-day practice, not just controlled research environments. The expectation is that funded projects will clarify which interventions are most effective for specific subgroups, what implementation barriers must be addressed, and what system changes can reliably improve outcomes for people living with HIV who also struggle with alcohol use.
From an administrative and funding standpoint, this is an R01 research project grant under NIH, with an estimated total funding amount of $2,500,000 and an expected 4 awards. The award ceiling is listed as $500,000, and there is no cost-sharing or matching requirement. The funding opportunity number is RFA-AA-13-003, posted March 27, 2013, with the original and current closing date of May 29, 2013, and an archive date of June 29, 2013. The activity category is Health, and the CFDA numbers associated with the announcement are 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
Eligibility is broad and includes many types of domestic U.S. organizations and governments, such as state, county, city or township governments; federally recognized tribal governments and other tribal organizations; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; independent school districts; special district governments; and public housing authorities/Indian housing authorities. The opportunity also explicitly allows non-U.S. entities and components: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined by the NIH Grants Policy Statement. It also lists additional eligible applicants such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, tribally controlled colleges and universities, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Overall, the grant is designed to move beyond simply proving that alcohol interventions can help people with HIV. Its focus is on figuring out what works best for whom and how to implement those approaches in ways that measurably improve retention in care, medication adherence, viral control, and ultimately reduce transmission and prevent avoidable illness and death.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R01)."
Which agency is offering this funding?
This is a National Institutes of Health (NIH) discretionary grant opportunity.
What type of award is this?
This is an NIH R01 research project grant.
What problem or gap is this funding intended to address?
The funding targets a persistent gap in HIV care: people living with HIV who drink heavily or have alcohol use disorders often do not receive alcohol-focused services that are well integrated with HIV treatment.
Why does NIH consider this gap important?
The announcement highlights that heavy alcohol use among people with HIV is associated with higher risks that directly affect HIV outcomes, including medication non-adherence, faster disease progression, higher likelihood of medication toxicities, organ damage or failure, poor viral suppression, increased chances of HIV transmission, and earlier mortality.
What public health impact does the announcement suggest could be achieved?
The notice cites estimates suggesting that improved implementation of alcohol interventions for people with HIV could reduce new infections by nearly 20 percent and extend life by as much as 15 years in certain at-risk and patient populations.
What is the main purpose of the solicitation?
The central purpose is to advance practical, decision-relevant evidence in two areas: (1) comparative effectiveness and (2) implementation. The goal is to help clinicians, health systems, and communities understand which alcohol-related interventions work best for different groups of people with HIV and how to deliver those interventions consistently and effectively in real-world settings.
What does the opportunity mean by "comparative effectiveness" in this context?
Comparative effectiveness research here focuses on comparing different alcohol-related interventions and approaches for people living with HIV, using outcomes that matter in HIV care (such as retention in care, adherence to antiretroviral therapy, and viral suppression), and examining what drives engagement and sustained participation in appropriate alcohol and HIV care.
What does the opportunity mean by "implementation" in this context?
Implementation research here focuses on modeling and testing alternative strategies for rolling out proven interventions in diverse real-world settings, evaluating how different delivery models affect HIV transmission and disease progression, and identifying scalable methods that work under practical constraints (such as staffing, reimbursement, workflow, and local infrastructure).
Is the announcement divided into parts?
Yes. The announcement is explicitly split into two parts. Applicants may choose to address one part or both.
What is Part 1 focused on?
Part 1 centers on comparative effectiveness research aimed at understanding what drives engagement in appropriate alcohol and HIV care and what helps people remain in treatment over time. It includes studying why some patients connect to services while others drop out, and how different approaches compare on outcomes such as retention, antiretroviral adherence, and viral suppression.
What is Part 2 focused on?
Part 2 focuses on modeling and testing alternative implementation approaches, including examining strategies for delivering proven interventions across diverse settings, evaluating different delivery models on HIV transmission and disease progression, and identifying scalable methods that can succeed under real-world constraints like staffing, reimbursement, workflow, and infrastructure.
What kinds of outcomes is NIH interested in for this research?
The opportunity emphasizes outcomes relevant to HIV care and prevention, including retention in care, adherence to antiretroviral therapy, viral suppression, HIV transmission risk, and disease progression. It also emphasizes reducing potential harms linked to interventions among HIV patients with varying severities and patterns of alcohol use.
What does the announcement emphasize about patient-centered care?
A core theme is patient-centered care and improved health care delivery research. The solicitation frames the work as producing evidence relevant to day-to-day practice, helping patients and providers make more informed decisions, and generating actionable knowledge rather than results limited to controlled research environments.
Does the opportunity encourage studying factors beyond the intervention itself?
Yes. Applicants are encouraged to investigate patient-level and provider-level characteristics (including factors shaping engagement, readiness, adherence, and care preferences), as well as organizational, financial, and structural conditions that support or block the delivery of evidence-based care.
What is the intended end product or expected contribution of funded projects?
The intended end product is actionable knowledge that improves clinical decision-making, strengthens treatment outcomes, and reduces potential harms, including identifying which interventions work best for specific subgroups and what system changes and implementation approaches can reliably improve outcomes.
What is the total estimated amount of funding for this opportunity?
The estimated total funding amount is $2,500,000.
How many awards does NIH expect to make?
The opportunity indicates an expected 4 awards.
What is the award ceiling?
The award ceiling is listed as $500,000.
Is cost sharing or matching required?
No. The announcement states there is no cost-sharing or matching requirement.
What is the funding opportunity number?
The funding opportunity number is RFA-AA-13-003.
When was this opportunity posted?
The opportunity was posted on March 27, 2013.
What was the closing date for applications?
The original and current closing date listed is May 29, 2013.
Is this opportunity archived?
Yes. The archive date listed is June 29, 2013.
What is the activity category?
The activity category is Health.
Which CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. organizations and governments, including state, county, city or township governments; federally recognized tribal governments and other tribal organizations; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; independent school districts; special district governments; and public housing authorities/Indian housing authorities.
Are foreign organizations eligible to apply?
Yes. The opportunity explicitly allows foreign organizations and foreign institutions to apply. It also states that non-U.S. components of U.S. organizations are eligible and that foreign components are permitted as defined by the NIH Grants Policy Statement.
Are U.S. territories or possessions included in eligibility?
Yes. The eligibility list includes U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The announcement lists faith-based or community-based organizations among eligible applicants.
Are minority-serving institutions included in the eligible applicants list?
Yes. The eligibility list includes HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities.
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
Do applicants have to address both comparative effectiveness and implementation research?
No. Applicants may choose to address Part 1, Part 2, or both parts.
What kinds of real-world constraints does the opportunity specifically mention for implementation research?
The announcement explicitly mentions constraints such as staffing, reimbursement, workflow, and local infrastructure.
What population is the focus of the research?
The focus is on people living with HIV who drink heavily or have alcohol use disorders, particularly because this population is described as underserved and at elevated risk for poor HIV outcomes.
What is the overall goal of the grant in plain language?
Overall, the grant is intended to move beyond showing that alcohol interventions can help people with HIV. It aims to determine what works best for whom and how to implement those approaches in ways that measurably improve retention in care, medication adherence, viral control, reduce transmission, and prevent avoidable illness and death.
Browse more opportunities from the same agency: National Institutes of Health
Browse more opportunities from the same category: Health
Next opportunity: Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R21)
Previous opportunity: Women, Peace and Security in Iraq
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AA 13 003
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AA 13 003) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R21) Apply for RFA AA 13 004 Funding Number: RFA AA 13 004 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Functional Characterization of Oral Cancer Initiating Cells (R01) Apply for RFA DE 14 001 Funding Number: RFA DE 14 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Functional Characterization of Oral Cancer Initiating Cells (R21) Apply for RFA DE 14 002 Funding Number: RFA DE 14 002 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| KNOWLEDGE FOR HEALTH II Apply for SOL OAA 13 000048 Funding Number: SOL OAA 13 000048 Agency: Agency for International Development Category: Health Funding Amount: $40,000,000 |
| Using Traditional Foods and Sustainable Ecological Approaches for Health Promotion and Diabetes Prevention in American Indian/Alaska Native (AI/AN) Communities CC RFA DP08 819 Apply for CDC RFA DP13 1317 Funding Number: CDC RFA DP13 1317 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $100,000 |
| Delta Health Care Services Program Apply for RBS01 2012 DHCS Funding Number: RBS01 2012 DHCS Agency: Business and Cooperative Programs Category: Health Funding Amount: Case Dependent |
| Alcohol Use Disorders Treatment, Services, and Recovery Research (R01) Apply for PA 13 160 Funding Number: PA 13 160 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Alcohol Use Disorders Treatment, Services, and Recovery Research (R21) Apply for PA 13 161 Funding Number: PA 13 161 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Alcohol Use Disorders Treatment, Services, and Recovery Research (R03) Apply for PA 13 162 Funding Number: PA 13 162 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Program to Support New Implementation of State or Territorial Public Health Laboratory Capacity for Newborn Bloodspot Screening of Severe Combined Immunodeficiency (SCID) Apply for CDC RFA EH13 1303 Funding Number: CDC RFA EH13 1303 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $400,000 |
| Strategic Prevention Framework Partnerships for Success (SPF PFS) Apply for SP 13 004 Funding Number: SP 13 004 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $2,260,000 |
| Secondary Analyses of Existing Data Sets and Stored Biospecimens to Address Clinical Aging Research Questions (R01) Apply for PA 13 168 Funding Number: PA 13 168 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Genomic Medicine Pilot Demonstration Projects (U01) Apply for RFA HG 13 004 Funding Number: RFA HG 13 004 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Improving HIV Prevention and Treatment Outcomes Among HIV Infected Persons by Integrating Community Pharmacists and Clinical Sites into a Model of Patient centered HIV Care Apply for CDC RFA PS13 1315 Funding Number: CDC RFA PS13 1315 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,300,000 |
| Medical Professionals Recruitment and Continuing Education Programs Apply for HHS 2013 IHS HPR 0001 Funding Number: HHS 2013 IHS HPR 0001 Agency: Indian Health Service Category: Health Funding Amount: $25,000 |
| NIDCR Small Research Grants for Secondary Analysis of FaceBase Data (R03) Apply for PAR 13 178 Funding Number: PAR 13 178 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Undiagnosed Diseases Gene Function Research (R21) Apply for RFA RM 13 003 Funding Number: RFA RM 13 003 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Implementation Science for Strengthening Use of Evidence in Family Planning/Reproductive Health Programming (ISSUE FP/RH) Apply for SOL OAA 13 000005 Funding Number: SOL OAA 13 000005 Agency: Agency for International Development Category: Health Funding Amount: $150,000,000 |
| Child, Newborn, and Maternal Health Project Apply for RFA 391 13 000009 Funding Number: RFA 391 13 000009 Agency: Pakistan USAID Islamabad Category: Health Funding Amount: Case Dependent |
| Indo U.S. Vaccine Action Program (VAP) Small Research Grant Program (R03) Apply for PA 13 179 Funding Number: PA 13 179 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AA 13 003", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.